Circulation
Articles in this Issue
Perspectives on the Future of Fundamental Sciences in Cardiovascular Medicine
Correction to: 2026 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
Loss of STMP1 Perturbs Mitochondrial Cristae and Drives Cellular Inflammation and Heart Failure
BACKGROUND: Heart failure is a leading cause of morbidity and mortality worldwide, particularly among the growing elderly population. In degenerative aging and autoimmune diseases,...
Left Ventricular Hypertrabeculation and Prognosis in Dilated Cardiomyopathy
BACKGROUND: Left ventricular (LV) hypertrabeculation, formerly termed LV noncompaction, is a heterogeneous myocardial entity linked to adverse cardiovascular outcomes. This study e...
Strategies for Optimizing Heart Failure Care in the Older Adult: A Scientific Statement From the American Heart Association
Heart failure prevalence is increasing and has a disproportionate burden on older adults. Older adults, however, may encounter unique challenges in accessing and navigating comprehensive disease-modif...
Late Gadolinium Enhancement in Nonischemic Dilated Cardiomyopathy
Letter by Wang and Wang Regarding Article, “Cardiac Allograft Vasculopathy Inhibition With Alirocumab: The CAVIAR Trial”
Defining Cardiovascular Endpoints in Oncology Trials: Challenges and Opportunities: A Scientific Statement From the American Heart Association
The unprecedented expansion of approved oncology therapies has prolonged survival and transformed the prognosis for many patients diagnosed with cancer. However, cancer treatments may be associated wi...
Ten Years of Scientific Discovery With the UK Biobank Cardiovascular Magnetic Resonance Imaging Study
The UK Biobank Imaging Study, with its dedicated cardiovascular magnetic resonance substudy, has redefined the scale and scope of cardiovascular research, generating high-quality imaging in 100 000 pa...
SREBP1 Transactivation of NHE3 Impairs Cardiac Contraction and Aggravates Heart Failure
BACKGROUND: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellula...
Association of Pulmonary Vascular Remodeling With Cardiac Structure and Function, Pulmonary Pressure, and Heart Failure in Late Life: The Atherosclerosis Risk in Communities (ARIC) Study
BACKGROUND: Aging is associated with increases in pulmonary pressure related to concomitant age-associated left ventricular remodeling, diastolic dysfunction, and declines in pulmo...