Circulation

Vol. 151, Issue 19 Issue 19 2025

Articles

Articles in this Issue

Targeting uPARAP Modifies Lymphatic Vessel Architecture and Attenuates Lymphedema

Fabrice Gucciardo, Alizée Lebeau, Sébastien Pirson et al. May 13, 2025 pp. 1412-1429 10.1161/circulationaha.124.072093

BACKGROUND: Lymphedema is an incurable disease associated with lymphatic dysfunction that causes tissue swelling and fibrosis. We investigated whether lymphedema could be at...

Mavacamten in Patients With Hypertrophic Cardiomyopathy Referred for Septal Reduction: Week 128 Results From VALOR-HCM

Milind Y. Desai, Kathy Wolski, Anjali Owens et al. May 13, 2025 pp. 1378-1390 10.1161/circulationaha.124.072445

BACKGROUND: In severely symptomatic patients with obstructive hypertrophic cardiomyopathy (HCM), VALOR-HCM trial (Study to Evaluate Mavacamten in Adults With...

Correction to: Sedentary Behavior and Light-intensity Physical Activity During Pregnancy and Cardiovascular Health: A Science Advisory From the American Heart Association

Kara M. Whitaker, Bethany Barone Gibbs, Marie-France Hivert et al. May 13, 2025 10.1161/cir.0000000000001340

Correction to: Mavacamten in Patients With Hypertrophic Cardiomyopathy Referred for Septal Reduction: Week 128 Results from VALOR-HCM

Milind Y. Desai, Kathy Wolski, Anjali Owens et al. May 13, 2025 10.1161/cir.0000000000001339

Ezh2 Shapes T Cell Plasticity to Drive Atherosclerosis

Cecilia Assunta Bonfiglio, Michael Lacy, Vasiliki Triantafyllidou et al. May 13, 2025 pp. 1391-1408 10.1161/circulationaha.124.072384

BACKGROUND: The activation and polarization of T cells play a crucial role in atherosclerosis and dictate athero-inflammation. The epigenetic enzyme EZH2 (enhancer of zeste homolog 2) medi...

Cell Type–Level Epigenetics at the Frontier of Atherosclerosis Research

Anthony S. Zannas May 13, 2025 pp. 1409-1411 10.1161/circulationaha.125.074275

Response by Reitan et al to Letter Regarding Article, “Excess Mortality and Loss of Life Expectancy After Myocardial Infarction: A Registry-Based Matched Cohort Study”

Christian Reitan, Pontus Andell, Robin Hofmann et al. May 13, 2025 10.1161/circulationaha.125.073963

Sedentary Behavior and Light-Intensity Physical Activity During Pregnancy and Cardiovascular Health: A Science Advisory From the American Heart Association

Kara M. Whitaker, Bethany Barone Gibbs, Marie-France Hivert et al. May 13, 2025 10.1161/cir.0000000000001316

The Physical Activity Guidelines for Americans supports sitting less and moving more. Growing evidence suggests that a waking behavior profile with less sedentary behavior and more light-intensity phy...