Circulation

The Elusiveness of “Rest”: The Challenges of Assessing Resting Coronary Physiology

A Pause, A Block, A Path Restored: The Heart’s Hidden Choreography

Optimizing Sedation Strategies for Catheter Ablation Procedures: Balancing Safety, Efficacy, and Practice Variations

COOPERATIVE-PFA: A Three-Arm Randomized Controlled Trial

BACKGROUND: Deep analgosedation (DAS) or general anesthesia is mandatory for pulsed-field ablation of atrial fibrillation. In contrast to DAS, general anesthesia (conventional or total int...

Stepwise Anatomical Approach to Ablation of Intramural Outflow Tract Ventricular Arrhythmias Guided by Septal Coronary Venous Mapping

BACKGROUND: The intramural site of origin is a major cause of ablation failure of ventricular arrhythmias, and the optimal strategy is unclear. This study investigated the efficacy of a st...

Mitochondrial Tumor Suppressor 1A Attenuates Myocardial Infarction Injury by Maintaining the Coupling Between Mitochondria and Endoplasmic Reticulum

BACKGROUND: Pathological cardiac remodeling after myocardial infarction (MI) is a leading cause of heart failure and sudden death. The detailed mechanisms underlying the transition to hear...

Letter by Pasupathy et al Regarding Article, “Zibotentan in Microvascular Angina: A Randomized, Placebo-Controlled, Crossover Trial”

Letter by Zhao Regarding Article, “Zibotentan in Microvascular Angina: A Randomized, Placebo-Controlled, Crossover Trial”

Safeguarding Biomedical Research Investments

Personalized Approach May Improve Hypertrophic Cardiomyopathy Diagnosis

Computational Modeling Predicts Benefits of Proefferocytic Therapy in Human Atherosclerosis

Device-Related Complications in Transvenous Versus Subcutaneous Defibrillator Therapy During Long-Term Follow-Up: The PRAETORIAN-XL Trial

BACKGROUND: The PRAETORIAN trial (A Prospective, Randomized Comparison of Subcutaneous and Transvenous Implantable Cardioverter Defibrillator Therapy) investigated the efficacy and...