Circulation

Non-Randomized Database Analyses to Complement Randomized Clinical Trials: Promising Approaches for Cardiovascular Medicine

From Passive to Proactive: A Call to Action on Valve Disease Screening

Atrial Translocation of <i>Porphyromonas gingivalis</i> Exacerbates Atrial Fibrosis and Atrial Fibrillation

BACKGROUND: Recent studies have indicated an association between periodontitis and atrial fibrillation (AF), although the underlying mechanisms remain unclear....

PCSK9 Promotes LDLR Degradation by Preventing SNX17-Mediated LDLR Recycling

BACKGROUND: Low-density lipoprotein (LDL) is internalized into cells mainly through LDLR (LDL receptor)–mediated endocytosis. In an acidic endosome, LDLR is released from LDL and recycles...

Electrical Alternance in a Patient With Type 1 Myotonic Dystrophy: What Diagnosis?

Letter by Luo et al Regarding Article, “Half-Life and Clearance of Cardiac Troponin I and Troponin T in Humans”

Electronic Provider Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: A Randomized Clinical Trial

BACKGROUND: Symptomatic severe aortic stenosis (AS) remains undertreated with high resultant mortality despite increased growth and availability of aortic valve replacement (AVR) s...

Response by Kristensen et al to Letter Regarding Article, “Half-Life and Clearance of Cardiac Troponin I and Troponin T in Humans”

Palliative Care and Advanced Cardiovascular Disease in Adults: Not Just End-of-Life Care: A Scientific Statement From the American Heart Association

Cardiovascular disease remains a leading cause of morbidity and mortality in adults despite recent scientific advancements. Although people are living longer lives, there may be an adverse impact on q...

Blood Pressure Lowering Effects of a Novel Long-Acting NPR1 Agonist, XXB750, in Healthy Participants: A Randomized, First-in-Human Clinical Study