Circulation
Articles in this Issue
Abstract 4354081: Coronary Artery Proximity to Potential Ablation Sites in Children
Background: Coronary artery (CA) injury from catheter ablation is an uncommon complication, but the risk is under recognized. In pediatrics, CA imaging to assess for CA proximity i...
Abstract 4370780: System-level Barriers and Facilitators to EHR Interventions in the Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Optimize Medications for Heart Failure with reduced ejection fraction (IICAPTAIN-HF) Trial
Background/Introduction: Guideline-directed medical therapies (GDMT) for patients with heart failure with reduced ejection fraction (HFrEF) result in significant improvements in ca...
Abstract 4364905: Beyond Glycemic Control: Cardiovascular Benefits of GLP-1 Receptor Agonists in Type 2 Diabetes
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as an essential therapy in type 2 diabetes mellitus (T2DM), providing cardiovascular benefits beyond g...
Abstract 4369356: Lipoprotein(a) and Metabolic Syndrome are Associated with Increased Risk of Coronary Heart Disease
Background: Lipoprotein(a) [Lp(a)] and metabolic syndrome (MetS) are well-established risk factors for cardiovascular disease. Recent evidence suggests that high Lp(a) levels may i...
Abstract 4358475: Prevalence, Clinical Profile, And Outcomes In ICU Patients With Prolonged QTc
Background: Acquired long QT syndrome is often underrecognized in critically ill patients, despite a high burden of contributing factors like electrolyte disturbances, medications,...
Abstract 4365804: AI-Based Prediction of Hemorrhagic Transformation Following Mechanical Thrombectomy: A National Inpatient Sample Analysis
Background: Hemorrhagic transformation (HT) is still a major negative outcome of mechanical thrombectomy (MT) in acute ischemic stroke (AIS), significantly affecting death rates an...
Abstract 4373696: Trends and Disparities in Coronary Artery Disease and Cardiac Arrest-Related Mortality in the United States, 1999-2023: Insights from the CDC WONDER Database
Background: Coronary artery disease (CAD), a leading cause of mortality in the United States, often leads to cardiac arrest. However, their combined mortality outcomes have not bee...
Abstract 4365505: Associations Between Calcium-Phosphate Ratio and Blood Pressure in Non-CKD Populations
Introduction: Serum calcium, phosphate, and their interaction have been linked to vascular calcification. While high calcium-phosphate ratio (Ca/P) has been associated with adverse...
Abstract 4363898: Genetic And Pharmacological Autophagy Inhibition Protects Against Autoimmune Myocarditis And Post-inflammatory Fibrosis In Mice
Background: Myocarditis is a serious inflammatory heart condition that can progress to post-inflammatory dilated cardiomyopathy. Autophagy is known to regulate immune cell function...
Abstract 4367056: Utilizing Epicardial Adipose Tissue As A Risk Marker For Patients With Chronic Kidney Disease
Background: Epicardial adipose tissue (EAT) “fat-omics” is an inflammation-sensitive depot that may provide prognostic information in cardiometabolic disease. Chronic Kidney Diseas...
Abstract 4370301: Endovascular Management of a Giant Right Coronary Artery Aneurysm With Right Atrial Compression
Description of Case: Giant coronary artery aneurysms (CAAs) are rare and pose diagnostic and therapeutic challenges, particularly when asymptomatic or incidentally discovered. Righ...
Abstract 4366487: Artificial Intelligence-Enabled Electrocardiogram for the Detection of Elevated Filling Pressure in Hypertrophic Cardiomyopathy and Cardiac Amyloidosis
Introduction: Diastolic dysfunction is a hallmark of heart failure with preserved ejection fraction, yet echocardiographic grading is challenging in patients with hypertrophic or a...
Abstract 4357375: Safety and Efficacy of the Aldosterone Synthase Inhibitor Osilodrostat in Primary Hypertension: A Retrospective Cohort Analysis
Background: Osilodrostat, the first-generation aldosterone synthase inhibitor, lowered aldosterone and blood pressure in phase II studies, but its real-world safety and efficacy in...
Abstract 4366523: Impact of Proton Pump Inhibitor Use on Cardiovascular Outcomes in Patients Receiving Dual Antiplatelet Therapy Post-PCI: A Systematic Review and Meta-Analysis
Introduction: Dual antiplatelet therapy (DAPT), combining aspirin and a P2Y12 inhibitor, is standard care following percutaneous coronary intervention (PCI). However, DAPT increase...
Abstract 4343735: Effect of Inflammatory Bowel Disease on Ablation Success and Predisposition for Atrial Fibrillation Recurrence
Background: Inflammatory bowel disease (IBD) has been shown to be associated with development of early ischemic heart disease and arrythmias, especially atrial fibrillation (AF). T...
Abstract 4355039: Sex and Social Disparities in Functional Recovery in Long COVID: A Cohort Study From a Latin American Population
Background: Long COVID is defined as a chronic condition that occurs after SARS-CoV-2 infection and persists for at least 3 months. It encompasses a wide spectrum of symptoms that...
Abstract 4357469: Blunt Trauma Causing Thrombotic Occlusive Myocardial Infarction
Case Description: A 66-year-old female presented to the emergency department after a motor vehicle collision. She presented with acute left-sided, burning, chest pain without radia...
Abstract 4370184: The Case for Living Homografts: Outcomes of Pediatric Prosthetic Aortic Valve Replacements using the Pediatric Health Information System Database
Background: Pediatric patients in which an aortic valve replacement (AVR) is required, the standard treatment would be an autologous AVR (aAVR), most often a pulmonary autograft. H...
Abstract 4368450: Psoas Muscle Index Is Associated With Native Heart Survival in Cardiogenic Shock Supported By Impella 5.5
Background: Frailty and sarcopenia are important predictors of outcomes in advanced heart failure. However, their prognostic value in patients with cardiogenic shock (CS) supported...
Abstract 4352077: A novel method for measuring HDL-bound unconjugated bilirubin using an eel fluorescent protein reveals its association with reduced coronary artery disease
Background: Owing to its antioxidant activity, unconjugated bilirubin (UCB) has been shown to have protective effects against oxidative stress-mediated diseases, including coronary...
Abstract 4361442: High-Intensity Interval Training Versus Moderate Continuous Training in Heart Failure with Preserved Ejection Fraction Patients with Chronotropic Incompetence: A 2025 Systematic Review
Background: Heart failure with preserved ejection fraction (HFpEF) frequently co-occurs with chronotropic incompetence (ChI), impairing the heart's ability to appropriately increas...
Abstract 4370144: Diagnostic Accuracy of Native T1 Mapping, Late Gadolinium Enhancement, and Extracellular Volume in Cardiac Amyloidosis: A Systematic Review and Meta-analysis
Background: Cardiac amyloidosis (CA) is a life-threatening infiltrative disorder that is frequently underdiagnosed due to its subtle and nonspecific clinical presentation. Accurate...
Abstract 4341827: Double Trouble — Exploring Mental Health Issues in Patients with Spontaneous Coronary Artery Dissection (SCAD) and Fibromuscular Dysplasia (FMD)
Background: Spontaneous Coronary Artery Dissection (SCAD) is a cause of acute coronary syndrome, particularly among women, and is associated with psychological distress, including...
Abstract 4360375: Subclinical cardiovascular complications among the adult patients with osteogenesis imperfecta
Background: Osteogenesis imperfecta (OI) is a congenital bone fragility disorder, in which 90% of patients have a deficiency or poor formation of type I collagen. Cardiovascular co...
Abstract 4370089: Large Language Models for Atrial Fibrillation Health Education for Asian Subgroups
Background: Large language models (LLMs) are used by atrial fibrillation patients. Cardiovascular outcomes may vary by Asian subgroup. Asians comprise 6% of the American population...