Circulation
Articles in this Issue
Abstract 4366476: Chronotherapy in Hypertension: A Meta-analysis on Comparative Effectiveness of Evening Versus Morning Dosing on Systolic Blood Pressure Control
Background: Blood pressure follows a circadian pattern, typically dipping at night and rising in the early morning. The timing of antihypertensive medication administration—known a...
Abstract 4363035: Temporal Trends in Obesity and Hypertension-Associated Mortality in the United States: Insights from CDC WONDER (1999–2020)
Introduction: Obesity is a known risk factor contributing to the development of hypertension. This study aims to identify integrated temporal trends, racial and ethnic disparities,...
Abstract 4366856: Phase Matters: Diastolic versus Systolic Chamber Volumetry from CAC CT Scans in Heart Failure Risk Stratification
Background: While non-contrast CT scans are routinely used to assess the risk of major adverse cardiac events by quantifying coronary artery calcium (CAC), there is growing interes...
Abstract 4357653: Impact of Transition from Micra VR to Micra AV on Heart Failure Hospitalizations in Patients with Atrioventricular Block
Background: Leadless pacemaker provides clinical advantages over traditional transvenous systems, including reduced risk of infections, thromboembolism, and lead-related complicati...
Abstract 4368814: Explainable AutoML-Derived XGBoost Model for One-Year Mortality Prediction in HFpEF Patients
Background: Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all heart failure hospitalizations; yet, tools for individualized 1-year morta...
Abstract Sun804: Resuscitative Balloon Occlusion of the Aorta with Head Up Cardiopulmonary Resuscitation VersusConventional Cardiopulmonary Resuscitation in a Porcine Model of Prolonged Cardiac Arrest
Background: Head Up Position (HUP) Cardiopulmonary Resuscitation (CPR) and Resuscitation Balloon Occlusion of the Aorta (REBOA) are emerging interventions for non-traumatic cardiac...
Abstract 4369720: Outcomes of Stylet-Driven Versus Non-Stylet-Driven Leads for Conduction System Pacing: Insights from the NCDR
Background: Conduction system pacing (CSP), including His bundle (HBP) and left bundle branch area pacing (LBBAP), is a growing alternative to traditional right ventricular or bive...
Abstract 4369550: Intraoperative Anaphylaxis in the Setting of Undiagnosed Alpha-Gal Syndrome: A Heart Team Clinical Conundrum
Alpha-gal syndrome (AGS) is a potentially life-threatening allergic reaction to galactose-alpha-1,3-galactose, a carbohydrate found in non-primate mammalian tissue. While reactions classically occur a...
Abstract 4357505: Early Cardioversion in Patients with both Cardiogenic Shock and Atrial Fibrillation Is Associated with Reduced Hospital Stay but Increased Odds of Acute Myocardial Infarction and Use of Mechanical Circulatory Support
Background: Atrial fibrillation frequently complicates cardiogenic shock, yet optimal rhythm management remains unclear. Early cardioversion aims to restore sinus rhythm and improv...
Abstract 4369071: Produce Prescription Delivery and Vouchers Are Feasible and Improve Nutrition Security and Diet Quality in Adults with Overweight and Obesity
Introduction/Background: Adults with overweight/obesity who face barriers to healthy food access are at increased risk of CVD. Produce prescription programs (PPP) may improve nutri...
Abstract 4368652: Real-World Risk Reduction of Cardiometabolic Comorbidities and Improvement of Biomarkers among Patients with Overweight or Obesity Treated with Semaglutide 2.4 mg
Introduction: Semaglutide 2.4 mg has been shown to reduce the risk and severity of cardiometabolic comorbidities (CMCs) and to improve cardiometabolic biomarkers in patients with o...
Abstract 4371627: COMPARISON OF CARDIOTOXIC EFFECTS AMONG BTK (BRUTON TYROSINE KINASE) INHIBITORS: A PHARMACOVIGILANCE ANALYSIS
Introduction: First-generation BTK inhibitors (BTKi) Ibrutinib showed benefits in the RESONATE-2 trial and have been widely used since then. However, its associated Cardiovascular...
Abstract 4368473: Comparative Outcomes of TEVAR and Non-TEVAR Management in Acute Uncomplicated Type B Aortic Dissection: Age-Stratified Analysis Using a Claims Database Including the Elderly in Japan
Background: Thoracic endovascular aortic repair (TEVAR) is the standard treatment for complicated type B aortic dissection, while randomized trials comparing TEVAR and optimal medi...
Abstract 4366696: Characterizing Exercise-Induced Myocardial Perfusion Response in Hypertrophic Cardiomyopathy and Heart Failure with Preserved Ejection Fraction
Background: Reduced myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) in the absence of epicardial coronary artery stenosis are commonly attributed to microvascula...
Abstract 4362647: Impact of LDL-C and Apolipoprotein B Discordance and Associated Lipoprotein Particle Changes on Major Adverse Cardiovascular Events in a Large Primary Prevention Cohort
Background: Emerging evidence suggests that ApoB outperforms LDL-C in predicting cardiovascular risk, especially in cases of discordance with the two. However, the specific type an...
Abstract 4340725: Hyperkalemia Sequelae in Patients With Chronic Kidney Disease, Heart Failure, Neither or Both: Findings From the TRACK Study
Background: Hyperkalemia (HK) prevalence in the general population is estimated at 2–3%; by contrast, prevalence is up to 73% in patients with CKD and 39% in those with heart failu...
Abstract 4359963: Endothelial Susceptibility-Related Genetic Variants and Hypertensive Disorders of Pregnancy
Introduction: The hypertensive disorders of pregnancy (HDPs), i.e., preeclampsia and gestational hypertension, are characterized by endothelial dysfunction in pregnancy and are epi...
Abstract 4370546: Incidence of Systolic Dysfunction After Alcohol Septal Ablation for Hypertrophic Cardiomyopathy: A Single-Center Experience
Introduction: Left ventricular systolic dysfunction (LVSD) is an uncommon late complication seen in patients with hypertrophic obstructive cardiomyopathy (HOCM). Prior studies esti...
Abstract 4342101: Development of a Metabolomics-Based Model for Predicting Atrial Fibrillation: A Prospective Case-Cohort Study
Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major cause of stroke and heart failure. Early identification of individuals at risk of A...
Abstract 4370097: Long-term Outcomes of Anticoagulation Guided by an Implantable Loop Recorder Following Catheter Ablation of Atrial Fibrillation
Background: Continued oral anticoagulation (OAC) following catheter ablation of atrial fibrillation (AF), even if successful in patients (pts) at a high risk of stroke, is recommen...
Abstract 4371939: Primary prevention of arrhythmic events in dilated cardiomyopathy: the role of genetic testing
Background: Dilated cardiomyopathy (DCM) is a genetically heterogeneous disease with variable arrhythmic risk. Implantable cardioverter-defibrillators (ICD) are used to prevent sud...
Abstract 4367418: Longer Door-to-Diuretic Time Is Associated with Increased In-Hospital Mortality among Acute Decompensated Heart Failure: Analysis of a Multi-Center Contemporary Cohort
Background: Diuretic administration is a cornerstone of acute decompensated heart failure (ADHF) treatment. Prior research suggest that delays in initial therapy in the emergency d...
Abstract 4371583: Donor-Derived Cell-Free DNA Stratifies Risk of Mortality and Graft Dysfunction in Severe Acute Cardiac Allograft Rejection
Introduction: Acute rejection (AR) is a risk factor for mortality following heart transplant. Prior studies relied on endomyocardial biopsy (EMB), an invasive gold standard with po...
Abstract 4366691: Cardiomyocyte Selective Overexpression of Protein Kinase G 1 Improves Left Ventricular Systolic And Diastolic Function in Murine Models of Cardiomyopathy
Background: We previously discovered that chronic deficiency of cardiac natriuretic peptides (NP) sensitized mice to sudden death and ventricular arrhythmias after acute myocardial...
Abstract 4365133: Impact of GLP-1 Analog Use on Clinical Outcomes Following Bariatric Surgery: A Propensity-Matched Retrospective Cohort Study
Background: GLP-1 receptor agonists have demonstrated cardiovascular and metabolic benefits in patients with obesity and type 2 diabetes. However, their impact on clinical outcomes...