Circulation

Colchicine: Evidence to Treat or Equipoise?

High Dietary Phosphate Intake Induces Hypertension and Sympathetic Overactivation via Central Fibroblast Growth Factor Receptor Signaling

BACKGROUND: Recent studies have highlighted the deleterious role of high phosphate intake in hypertension via sympathetic overactivation, yet the underlying mechanisms remain unclear. Diet...

New Algorithm for Estimating Left Ventricular Filling Pressure by Echocardiography

BACKGROUND: Evaluation of whether dyspnea has a cardiac cause is essential. Guidelines from 2016 were reported to result in a high incidence of indeterminate left ventricular (LV)...

Letter by Kornelius Regarding Article, “Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial”

Reformulation of the Necroptosis Pathway in Reperfused Myocardial Infarction

Response by Docherty et al to Letter Regarding Article, “Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial”

An Uncommon Manifestation of a Common Disease

Genomic Editing of a Pathogenic Sequence Variant in <i>ACTA2</i> Rescues Multisystemic Smooth Muscle Dysfunction Syndrome in Mice

BACKGROUND: Vascular smooth muscle cells (SMCs), the predominant cell type in the aortic wall, play a crucial role in maintaining aortic integrity, blood pressure, and cardi...

DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases

BACKGROUND: The association of overall cardiovascular health (CVH) with changes in DNA methylation (DNAm) has not been well characterized....