Circulation

Cas13-Mediated RNA Base Editing for the Treatment of Hereditary Hypertrophic Cardiomyopathy

Evaluating Cardiovascular Devices Using Observational Analyses

It has long been accepted that observational analyses have an important role in evaluating use patterns and assessing the safety of different treatments, including cardiovascular devices, in clinical...

Targeting Lymph Node Entry to Improve Cardiac Graft Tolerance

A New Dawn for Pre-Hospital Heparin in STEMI? Insights From the HEPARIN STEMI Trial

Letter by Pan and Ding Regarding Article, “Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells”

HEV-Targeted Antibody-Drug Conjugate Promotes Long-Term Cardiac Allograft Acceptance

BACKGROUND: The entrance of naive T cells into lymph nodes (LNs) is a crucial step for induction of heart transplant acceptance under costimulatory blockade. Specialized blood vess...

Response by Chen and Duan to Letter Regarding Article, “Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells”

Prehospital Heparin Administration in Patients With STEMI Undergoing Primary PCI: HEPARIN-STEMI Randomized Controlled Trial

BACKGROUND: Primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy for patients with ST-segment–elevation myocardial infarction (STEMI). We investig...

Effect of APOC3 Inhibition With Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study

BACKGROUND: Whether lowering triglyceride-rich lipoproteins and remnant cholesterol favorably modifies coronary atherosclerosis is unclear. Olezarsen, an antisense oligonucleotide...

Incretin-Based Therapies and Cardiovascular Outcomes: Beyond Weight Loss