Circulation

A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease

BACKGROUND: Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes i...

Correction to: Comparative Cardiovascular Effectiveness of Empagliflozin Versus Dapagliflozin in Adults With Treated Type 2 Diabetes: A Target Trial Emulation

SGLT Inhibitors in Persons With Heart Failure and Type 1 Diabetes: Filling the Therapeutic Gap

Correction to: Risk of Stroke or Systemic Embolism According to Baseline Frequency and Duration of Subclinical Atrial Fibrillation: Insights From the ARTESiA Trial

Fractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Coronary Artery Disease

BACKGROUND: ORBITA-2 (the Placebo-Controlled Trial of Percutaneous Coronary Intervention for the Relief of Stable Angina) provided evidence for the role of percutaneous coronary interventi...

An Advocacy Agenda for the Human Brain: Moving From Brain Health to Brain Capital

Letter by Wang and Peng Regarding Article, “Ertugliflozin for Functional Mitral Regurgitation Associated With Heart Failure: EFFORT Trial”

In Which Patients Will Percutaneous Coronary Intervention Relieve Angina?

Survivorship After Cardiogenic Shock

Advances in critical care therapies for patients with cardiogenic shock (CS), including temporary mechanical circulatory support and multidisciplinary shock teams, have led to improved survival to hos...

Association Between Delay to First Shock and Successful First-Shock Ventricular Fibrillation Termination in Patients With Witnessed Out-of-Hospital Cardiac Arrest

BACKGROUND: In patients with out-of-hospital cardiac arrest who present with an initial shockable rhythm, a longer delay to the first shock decreases the probability of survival, often att...

Driving Restrictions and Incapacitation Vulnerability Evaluation After ST-Segment–Elevation Myocardial Infarction: DRIVE-STEMI Study

Response by Park and Kang to Letter Regarding Article, “Ertugliflozin for Functional Mitral Regurgitation Associated With Heart Failure: EFFORT Trial”

Associations of Circulating ANGPTL3, C-Terminal Domain–Containing ANGPTL4, and ANGPTL3/8 and ANGPTL4/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality

BACKGROUND: ANGPTL3/4/8 (angiopoietin-like proteins 3, 4, and 8) are important regulators of LPL (lipoprotein lipase). ANGPTL8 forms complexes with ANGPTL3 and ANGPTL4. ANGPTL4/8 complex f...

ADMET-AI Enables Interpretable Predictions of Drug-Induced Cardiotoxicity

AL or ATTR Amyloidosis? Never Two Without Three