Circulation
Articles in this Issue
Abstract 4371038: Exploring Real-World Barriers to Statin Use Through Reddit Conversations Using LLM with Expert-in-the-Loop
Introduction: Statin nonadherence remains a challenge—over 50% discontinue within one year. Clinical barriers include side effects and poor communication, but patient perspectives...
Abstract 4373606: Short-Term Dual Antiplatelet Therapy Following Percutaneous Intervention Does Not Impact Stroke Outcomes: A Meta-Analysis of Randomized Controlled Trials
Background: Dual-antiplatelet therapy (DAPT) is recommended after percutaneous coronary intervention (PCI) to reduce recurrent ischemic events, though optimal duration is unclear....
Abstract 4373674: Association Between Chronic Proton Pump Inhibitor Use and Adverse Cardiovascular Outcomes in Adults Undergoing Coronary Artery Calcium Imaging
Background: Proton pump inhibitors (PPIs) are commonly prescribed for acid-related conditions, especially in patients with cardiovascular risk factors. Although widely considered s...
Abstract 4344498: Real time assessment of Primary Care Hypertension Management in an Urban Health System using MDClone
Background: Primary Care Providers (PCPs) diagnose patients with hypertension (HTN) and initiate antihypertensive therapies that prevent end organ damage. Outpatient HTN management...
Abstract 4370068: Clinical Outcomes of Conduction System Pacing Versus Right Ventricular Pacing: A Systematic Review and Meta-Analysis of Initial Pacemaker Implantation
Background: Right ventricular pacing (RVP) is the standard approach for bradyarrhythmia but is linked to adverse outcomes like pacing-induced cardiomyopathy and heart failure. Cond...
Abstract 4364290: Immune and Proteomic Dysregulation in Single Ventricle Congenital Heart Disease
Background: Immune dysregulation and chronic inflammation have been documented in children and adults who have undergone Fontan palliation for single ventricle heart disease (SV)....
Abstract 4373582: Phenotypic Age Predicts Long-Term Cardiac Outcomes Better Than Chronological Age in Patients with Acute Myocardial Infarction
Background: Phenotypic Age (PhenoAge), which is calculated based on chronological age and nine biomarkers, has been shown to better predict in-hospital outcomes in patients with ac...
Abstract 4370722: The Association between C-Reactive Protein-Triglyceride-Glucose Index and Cardiovascular Mortality in Patients with Metabolic Syndrome
Introduction: Metabolic syndrome is characterized by an interplay of risk factors mediated by a chronic state of inflammation and is strongly linked to increased cardiovascular (CV...
Abstract 4369278: Real-World Adverse Events of the Aurora Extravascular Implantable Cardiac Defibrillator: Insights from the United States FDA MAUDE Registry
Introduction: Extravascular implantable cardioverter defibrillators (EV-ICD) utilize a substernal lead to provide the benefits of ICDs without associated vascular risks. Only a few...
Abstract 4348302: Olpasiran Outperforms Other Subcutaneous Lipoprotein(a)-Lowering Agents in Efficacy and Safety: A Network Meta-Analysis of Randomized Controlled Trials
Introduction: Elevated lipoprotein(a) [Lp(a)] is an independent and causal risk factor for cardiovascular disease (CVD). R...
Abstract 4364012: Machine Learning-Enabled Papillary Muscle Fibrosis Assessment in 51,000 Individuals Reveals Independent Links to Cardiac Structure, Function, and Disease and Identifies Genetic Susceptibility Loci
Background: Mitral valve prolapse (MVP) affects 1–3% of the population and is linked to sudden cardiac death (SCD). Papillary muscle (PM) fibrosis, detectable by cardiac magnetic r...
Abstract 4370283: Real-World Effectiveness of GLP-1 Receptor Agonists on Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction (HFpEF).
Introduction/Background: Multiple clinical trials have demonstrated that glucagon-like peptide 1 receptor agonists (GLP-1 Ras) improve symptoms, physical function, and potentially...
Abstract 4368722: Photobiomodulation Protects the Cardiorenal Axis in Diabetic Nephropathy
Introduction: Dysregulation of the cardiorenometabolic axis in Diabetes Mellitus (DM) induces a complex pathophysiological cascade involving oxidative stress, systemic inflammation...
Abstract 4367376: Left Atrial Appendage Closure in Cancer Patients with Atrial Fibrillation: A National Inpatient Sample Study (2016–2020)
Background: Stroke prevention in cancer patients with atrial fibrillation (AF) is challenging due to competing thrombotic and bleeding risks, which complicate anticoagulation strat...
Abstract 4358710: Longterm outcomes of percutaneous endocardial septal radiofrequency ablation for patients with hypertrophic obstructive cardiomyopathy
Background: Percutaneous endocardial septal radiofrequency ablation (PESA) holds promise as a minimally invasive interventional treatment for drug-refractory hypertrophic obstructi...
Abstract 4344863: Diagnostic ability of mid-coronary artery wall echogenicity in the initial diagnosis of Kawasaki Disease
Background: Periarterial echogenicity in the proximal coronary arteries is known to increase in the acute phase of Kawasaki disease (KD). However, some studies have questioned its...
Abstract 4365737: Intensive Lifestyle Intervention Strategies for Improving Atherogenic Profile and Estimated Cardiovascular Risk in Indian Adults with Obesity
Introduction: Obesity-related cardiovascular (CV) risk is a growing concern in India, even in the absence of diabetes. Lifestyle intervention strategies may play a role in improvin...
Abstract 4371086: Population-scale AI Measurement of the Aorta Identifies Novel Traits Associated with Aortic Diameter
Introduction: Aortic diameter is influenced by age, sex, body surface area (BSA), and race. Studies of aortic diameter have been limited due to small sample size or focus on specif...
Abstract 4346087: In-Hospital Outcomes of Surgical Versus Transcatheter Aortic Valve Replacement in Patients with Dementia
Severe aortic stenosis (AS) is a progressive, life-threatening condition associated with significant morbidity and mortality. Current guidelines recommend shared decision-making regarding transcathete...
Abstract 4368129: Low-Density Lipoprotein Cholesterol Levels after STEMI Complicated by Heart Failure and Prognosis: A Real-World Cohort Study
Background: Intensive lipid-lowering therapy can significantly reduce the risk of major adverse cardiovascular events (MACE) in patients with ST-segment elevation myocardial infarc...
Abstract 4366626: Mast Cell Stabilization Enhances Hemorrhage Resolution and Attenuates Adverse Remodeling in Reperfused Myocardial Infarction
Purpose: Evidence suggests that mast cells (MCs) become overstimulated during reperfusion after a period of prolonged myocardial ischemia. However, the role of MC degranulation on...
Abstract 4348151: Employment-Related Social Determinants of Health and Cardiovascular Risk in the Fourth Trimester: A 15-Year Comparative Outcomes Analysis Using Real-World Data
Background: Employment instability and related socioeconomic stressors are increasingly recognized as critical social determinants of health (SDOH) affecting maternal cardiovascula...
Abstract 4368643: Acute Kidney Injury Due to Hemolysis After Pulsed Field Ablation: A Case with Limited Lesion Burden
Background: Pulsed field ablation (PFA) is a novel nonthermal technique for atrial fibrillation that uses high-voltage electrical pulses to achieve myocardial ablation with a favor...
Abstract 4362864: Echocardiographic Assessment of Shock Using Right Ventricular–Pulmonary Artery Uncoupling in Acute Pulmonary Embolism
Introduction: Right ventricular–pulmonary arterial (RV–PA) coupling refers to the relationship between right ventricular contractility and its afterload. This relationship can be n...
Abstract 4363503: Reverse Takotsubo Cardiomyopathy Triggered by Acute Pancreatitis: Rare Stress-Induced Cardiac Syndrome
Introduction: Takotsubo cardiomyopathy is an uncommon condition characterized by transient regional systolic dysfunction, which can mimic an acute myocardial infarction in the abse...