Circulation
Articles in this Issue
Abstract 4369203: Mortality Rates and Causes of Death in Patients with Congenital Heart Disease (CHD) Across the Lifespan: Population-Based Findings from the CDC-Funded STAR1 Study
Introduction: Despite the growing number of patients (pts) with CHD, US population-wide data on mortality rates (MR) and causes of death (COD) remain limited. We describe the moder...
Abstract 4336037: Successful Management of Acute Ischemic Stroke in the Context of Chronic Stanford Type A/DeBakey Type I Aortic Dissection: A Multidisciplinary Approach with Mechanical Thrombectomy via Direct Carotid Artery Access
Introduction: Acute ischemic stroke is a known complication of aortic dissection (AD), either by extension, thromboembolism, or cerebral hypoperfusion. The incidence ranges from 6–...
Abstract 4365771: Exercise Dose During Home-Based Cardiac Rehabilitation and Mortality
Background: Cardiac rehabilitation (CR) improves cardiovascular outcomes. While a dose-response relationship is well established in center-based CR (CBCR), the optimal exercise “do...
Abstract 4367861: Thrombolysis for Minor Non-Disabling Ischemic Stroke: A Meta-analysis of Randomized Controlled Trials
Background: The optimal management of minor ischemic stroke without clearly disabling neurologic deficits remains controversial. Despite the widespread use of intravenous thromboly...
Abstract 4341515: Outcomes of Bacteremia and Infective Endocarditis in Patients with Cardiac Implantable Electronic Devices: The Role of Device Removal
Background: Cardiac implantable electronic devices (CIEDs) are increasingly used to manage various cardiac conditions but are linked to a higher risk of severe infections, includin...
Abstract 4363694: Time Trends and Demographic Disparities in Pulmonary Hypertension-Related Mortality in the United States, 2003–2023
Background: Pulmonary hypertension (PH) is a major contributor to cardiovascular mortality. With the recent lowering of the diagnostic threshold, updated analyses are needed to ass...
Abstract 4360980: Evaluating Gaps in Cardiac Rhythm Monitoring Completion in a Post-Stroke Population
Background: Cardiac rhythm monitoring is a mainstay of secondary stroke prevention. Despite this, prior studies have highlighted gaps in real-world monitoring after stroke....
Abstract 4367519: Frequency and mid-term outcomes of permanent pacemaker implantation pre- and post-transcatheter aortic valve implantation: A single-center experience in Japan using new-generation valves
Introduction: Atrioventricular block is a known complication of transcatheter aortic valve implantation (TAVI). However, the prognostic effect of permanent pacemaker implantation (...
Abstract 4371044: Revisiting the Diabetes Paradox in Aortic Dissection: A Multivariate Analysis from NIS 2022
Background: The role of diabetes mellitus (DM) in Type A aortic dissection (TAAD) mortality is controversial, with some studies suggesting protection and others equating DM to risk...
Abstract 4366397: Clinical Outcomes associated with FDA-Labeled and Non-FDA-Labeled Direct Oral Anticoagulant Dosing in US Patients with Atrial Fibrillation, Stratified by Gender: A Real-World Data Study
Background: Atrial fibrillation (AF) is a prevalent condition impacting millions globally. It poses significant thrombotic risks, ranging from stroke to sudden cardiac death, thus...
Abstract 4363400: Readmission and Outcomes in Patients with Pulmonary Embolism requiring either Catheter Directed Thrombolysis or Mechanical Thrombectomy.
Introduction: Pulmonary embolism (PE) is a critical condition requiring prompt and effective treatment to reduce morbidity and mortality. Catheter-directed thrombolysis (CDT) and m...
Abstract 4364054: Prevalence and Clinical Correlates of Valvular Abnormalities in Systemic Sclerosis: Associations with Pulmonary Vascular and Disease Severity
Background: Cardiac involvement is a major contributor to morbidity and mortality in systemic sclerosis (SSc), yet valvular heart disease remains underrecognized. Fibrotic and vasc...
Abstract 4365834: Temporal and Demographic Trends in Mortality Among Patients with Intracranial Bleed and Concurrent Heart Failure: A 25-Year Analysis Using the CDC WONDER Database (1999–2024)
Background: Co-morbid heart failure has been associated with increased mortality and worse outcomes in patients with intracranial bleeds. This occurs because such patients are more...
Abstract 4370211: Racial Differences in Transcatheter Aortic Valve Replacement in a Majority-Minority Population: A Decade-Long Analysis in Hawaii
Introduction: Native Hawaiians and Pacific Islanders (NHPI) have disproportionately high rates of heart disease. Transcatheter percutaneous aortic valve replacement (TAVR) is an al...
Abstract 4365714: Inhibition of miRNA-375-3p in vascular cells restores cellular functions in the context of cellular ageing
Background: Ageing is a major driving factor for vascular changes. Over time, senescent endothelial and smooth muscle cells accumulate in the vasculature, promoting endothelial dys...
Abstract 4361819: Sex Differences in Response to Endurance Training
Background: Few studies have systematically evaluated whether adaptations to endurance training differ by sex. We assessed sex differences in cardiopulmonary, body composition, and...
Abstract 4363990: Endothelial Dysfunction Induced by 6-Methylnicotine, a Novel Nicotine Analog, in Murine Blood Vessels In Vitro
Background: The presence of synthetic nicotine analogs in "tobacco-free" products, such as 6-methylnicotine (6MN) in SPREE BAR (aka Metatine™), presents regulatory and public healt...
Abstract 4366176: Impact of Extensive Linear Ablation Strategies on the success of Atrial Antitachycardia Pacing in Refractory Atrial Arrhythmias
Background: Although pulmonary vein isolation (PVI) is the cornerstone of atrial fibrillation (AF) management, recurrence of AF and atrial tachycardia (AT) remains a significant ch...
Abstract 4367137: Disparities in Percutaneous Coronary Intervention and Outcomes Among Patients With and Without Dementia Hospitalized for Acute Coronary Syndrome: A Nationwide Propensity Score–Matched Analysis
Introduction: Older age and multimorbidity observed in individuals with dementia may impact both the care they receive and their outcomes in the setting of acute coronary syndrome...
Abstract 4364440: Biogenic <i>RYR2</i> Loss-of-Function Disrupts Intracellular Calcium Handling and Induces Electrical Remodeling in Re-Engineered Human Cardiomyocytes
Background: Calcium release channel deficiency syndrome (CRCDS) is caused by biogenic or biophysical loss-of-function (LOF) pathogenic varia...
Abstract 4360376: Effect Of Inclisiran-based Treatment Strategy, In Combination With Individually Optimized Statin Therapy, On Quality Of Life And Muscle-related Pain vs. Standard of Care: Exploratory Outcomes From The VICTORION-Difference Study
Background: Inclisiran provides sustained and effective LDL-C reduction in individuals with hyperlipidemia with a favorable long-term safety profile; however, its impact on QoL rem...
Abstract Sun101: Physiology of ventilation during flat and head-up cardiopulmonary resuscitation: a multi-model study
Background: Ventilation during cardiopulmonary resuscitation may affect cardiac arrest management and outcome. Novel strategies such as head and thorax elevation (HTE) and the use...
Abstract 4363645: Presence of Cardiac Calcification After Congenital Heart Surgery Predicts Cardiac Complications
Introduction/Background: CT has been utilized to visualize cardiac calcification (CC). This tool has primarily been used to assess the burden of coronary artery disease, with estab...
Abstract 4360020: From Wrist to Risk: Advancing Cardiovascular Prediction Using Wearables
Background: Behavioral factors such as physical activity, sleep, and heart rate are associated with cardiovascular (CV) health but are not used in current CV risk prediction tools....
Abstract 4363116: HEPATIC DELIVERY OF MICRORNA-30C ANALOG C2 REDUCES PLASMA CHOLESTEROL IN MICE AND MONKEYS AND ATHEROSCLEROSIS IN MICE WITHOUT CAUSING LIVER INJURY
Background: Despite the availability of many drugs, cardiovascular disease (CVD) remains a major cause of premature mortality worldwide. High plasma cholesterol (chol) levels are r...