Angewandte Chemie International Edition
Articles in this Issue
Nickel‐Catalyzed Umpolung Difluoroalkylation of Imines Enables General Access to β‐Difluoroalkylated Amines
Abstract Fluoroalkylated amines play a pivotal role in medicinal chemistry, yet the general and efficient synthesis of β‐difluoroalkylated amines remains elusive. Here, we developed...
Optimizing the Selectivity of CH <sub>4</sub> Electrosynthesis from CO <sub>2</sub> Over Cuprates Through Cu─O Bond Length Descriptor
Abstract Precisely controlling the nature of Cu─O bond in Cu‐based oxide catalysts and understanding its correlation with CH 4...
A 3D Hybrid Perovskite Ferroelastic with Triclinic‐to‐Cubic Phase Transition Boosts Temperature/Pressure Dual On/Off Switchable Birefringence
Abstract Birefringent crystals have gained enormous attention for decades due to their unique ability to manipulate polarized light. However, achieving the fasci...
Structural Basis of Sequential Enantioselective Epoxidation by a Flavin‐Dependent Monooxygenase in Lasalocid A Biosynthesis
Abstract Polyether polyketides are a structurally diverse group of natural products known for their antimicrobial and antiproliferative activities. Lasalocid A i...
New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain
Abstract Delivery across the blood–brain barrier (BBB) is one of the most challenging tasks for modern biopharmaceutics. Many attempts have been taken, with only low delivery efficac...
Short Lifetime Radical Metal Cluster Scintillator
Abstract Metal clusters, an emerging class of scintillator materials, have attracted much attention owing to their inherently high X‐ray absorption, mild synthes...
High‐Pressure Synthesis of Ultra‐Incompressible Beryllium Tungsten Nitride Pernitride BeW <sub>10</sub> N <sub>14</sub> (N <sub>2</sub> )
Abstract For the activation of nitrogen and its reduction to ammonia, transition metals are crucial in biological as well as industrial processes. So far, only a...
Self‐Optimized Reconstruction of Metal–Organic Frameworks Introduces Cation Vacancies for Selective Electrosynthesis of Hydrogen Peroxide
Abstract The electrocatalytic synthesis of hydrogen peroxide (H 2 O 2 ) through t...
Tandem Biocatalysis to Generate Hydrogen Sulfide and Promote Endogenous Antioxidant Response
Abstract Promoting cellular protective responses during oxidative stress conditions through the generation of antioxidant persulfide (RS‐SH) and hydrogen sulfide...
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β <sub>2</sub> ‐Adrenoceptor
Abstract The β 2 ‐adrenergic receptor (β 2 AR) is a critical target for the treat...
Manipulation of Chemistry and Biology with Visible Light Using Tetra‐ <i>ortho</i> ‐Substituted Azobenzenes and Azonium Ions
Abstract Molecular photoswitches are used for precise and reversible control over the properties and function of chemical, biological and material systems, offer...
Integrating Ambient Ionization Mass Spectrometry Imaging and Spatial Transcriptomics on the Same Cancer Tissues to Identify RNA–Metabolite Correlations
Abstract Innovations in spatial omics technologies applied to human tissues have led to breakthrough discoveries in various diseases, including cancer. Two of these approaches—spatia...