Angewandte Chemie International Edition
Articles in this Issue
Anomalous Piezochromic Luminescence in Covalent Triazine Frameworks via Molecular Insertion: Blueshifted and Enhanced Emission
Abstract Piezochromic materials typically exhibit pressure‐induced redshifted and quenched emission due to enhanced intermolecular π–π stacking and molecular planarization. Consequen...
A Monolithium Monohydrogen Porphyrin
Abstract Porphyrins and their metal complexes play essential roles in biological and industrial processes, functioning as key components in catalysis, photodynam...
Reverse the Impact of Le Chatelier's Principle in Two‐Electron Air Electroreduction
Abstract Using high‐purity oxygen (O 2 ) for electrofixation would increase the production cost of hydrogen peroxide (H...
“Pseudo‐Charge‐Transfer Complex” Electrolyte Enables 490 Wh Kg <sup>−1</sup> Lithium Metal Battery Operated From −40 to 80 °C
Abstract Electric vehicles and electric aircraft demand all‐climate lithium metal batteries (LMBs) with high energy density. However, the interaction mechanism b...
Oxidative Electrocyclization Assembles 2,2‐Dimethyl‐2 <i>H</i> ‐pyran in Fungal Indole Alkaloids
Abstract Pericyclic reactions, such as cycloaddition and electrocyclization, are among the most useful approaches for constructing complex natural products with...
Location‐Differentiated DNA Hierarchical Cyclic Construction Demarcating Identical Biomolecules Across Cell Membrane Microenvironments
Abstract Local molecular composition across cell membrane microenvironments exerts profound effects on cellular physiology and pathology. Yet spatial demarcation of identical biomole...
Hydrogen‐Bond‐Directed Supramolecular Organic Semiconductor Thin Films Realized via Thermal Precursor Approach
Abstract Flexible organic semiconductors are regarded as an important class of functional materials, enabling their fabrication via a solution‐processed method....
Outside Front Cover: High‐Performance FeP Catalyst for Electrochemical Ammonia Production and Recovery via Joule‐Stripping (Angew. Chem. Int. Ed. 31/2025)
Deuterating Narrow‐Bandgap Organic Semiconductors for Sensitive Short‐Wave Infrared Photodetection
Abstract Organic semiconductors exhibit significant potential for next‐generation optoelectronic technologies owing to their structural tunability and solution p...
Mechanistic Promiscuity in Cobalt‐Mediated CO <sub>2</sub> Reduction Reaction: One‐ Versus Two‐Electron Reduction Process
Abstract We compare the carbon dioxide reduction (CO 2 RR) activity and selectivity of the complexes [...
Rhodium‐Catalyzed Asymmetric Access to P‐Chiral Triarylphosphine Oxides via Insertion of P─H Bonds into Diazonaphthoquinones
Abstract While significant progress has been made in the enantioselective insertion of carbenes into heteroatom‐hydrogen bonds, this chemistry is restricted to the construction of ca...
Dual Enzyme‐Responsive Polymer‐Drug Conjugates Induce Diverse Cells Mutual Transcytosis to Achieve Deep Pancreatic Tumor Penetration
Abstract Enzyme‐responsive active transporting nanomedicines have shown promise in overcoming the tumor‐dense extracellular matrix barrier by inducing cancer cells’ intercellular tra...
Rhodium‐Catalyzed 1,5‐Sigma Migratory Ring Expansion of <i>gem</i> ‐Difluorodienyl Cyclopropanes and Cyclobutanes
Abstract Rhodium‐catalyzed 1,5‐sigma migratory ring expansion (SMRE) of common dieneylcyclopropanes (DECPs) and dieneylcyclobutanes (DECBs) fails. But replacing...
Self‐Promoting Targeted Delivery of Epigenetic Immunostimulants to Activate Breast Cancer Immunity via HDACs Downregulation and PD‐L1 Upregulation
Abstract The low immunogenicity and immunosuppressive phenotype of breast cancer significantly limit the effectiveness of immunotherapy. This study reveals that histone deacetylases...
Simple and Rapid Tumor EV Enrichment Enabled by Long DNA Probe‐Guided Entanglement
Abstract Specific subpopulations of extracellular vesicles (EVs) hold significant clinical potential for biomarker discovery, disease diagnosis, and therapeutic...
A Diazo Linker Ligand Promotes Flexibility and Induced Fit Binding in a Microporous Copper Coordination Network
Abstract Flexible organic linkers represent an intuitive and effective strategy to design flexible metal–organic materials. We report herein a systematic study c...
HF‐Free Manufacturing of Fluorochemicals from Fluorspar
Abstract Fluorochemicals are vital in modern chemistry, from batteries to agrochemicals and pharmaceuticals. However, their production still relies on a centuries‐old method involvin...
Ferromagnetic Ordering Outperforms Coordination Effects in Governing Oxygen Reduction Catalysis on High‐Index Nickel Single Crystals
Abstract The role of surface spin configuration in spin‐dependent catalytic reactions remains contentious, particularly when compared to the established dominanc...
Regulating Solvating Sites for Stable High‐Voltage Lithium Metal Batteries
Abstract The long‐lasting stability of high‐voltage lithium metal batteries (LMBs) critically rely on both the cathodic and anodic stability of electrolytes, whi...
Unexpected Activities of CYP152 Peroxygenases Toward Non‐carboxylic Substrates Reveal Novel Substrate Recognition Mechanism and Catalytic Versatility
Abstract Exploring and exploiting the catalytic promiscuity of enzymes is a central topic and captivating challenge in enzymology. CYP152 peroxygenases are attra...
ABC‐seq Expands Small RNAs Profiling with Successive Nucleic Acid Structure‐Differentiated Enzymatic Recognition
Abstract Small RNAs (smRNAs) play crucial roles in gene regulation, but current sequencing methods face a set of tangled challenges, including adapter ligation bias, high adapter dim...
Hetero‐Selective Cross‐Linking of Primary and Secondary Alkyl Amines with CS <sub>2</sub> Under Ambient Aerobic Oxidation for Bioconjugation
Abstract Umpolung of primary amines via isothiocyanation presents an attractive approach for cross‐linking biorelevant molecules through two nucleophilic handles...
Completing the Biosynthesis of the Clinically Important Diterpenoid Andrographolide in <i>Andrographis Paniculata</i>
Abstract Andrographolide is a prominent labdane diterpenoid extracted from Andrographis paniculata with exceptional anti‐...
Activatable Fluorescence/Photoacoustic Macromolecular Probe for Imaging of Tumor‐Associated Natural Killer Cells
Abstract Detection of tumor‐associated natural killer cells (TANKs) is crucial for evaluating cancer immunotherapy because they are found to be associated with i...
Atomic Heterointerface Engineering and Nonequilibrium Carrier Dynamics for Enhanced Photocatalysis in Halide Perovskite/MoS <sub>2</sub> Systems
Abstract Halide perovskites hold promise for solar‐driven photocatalysis in fuel production owing to their superior light absorption and carrier diffusion. Howev...