Angewandte Chemie International Edition
Articles in this Issue
Biocatalytic Alkylation of Ambident Nucleophiles Enables Selective <i>N</i> ‐Functionalization of Heterocycles and Late‐Stage Modifications
Abstract The alkylation with electrophilic haloalkanes is a key methodology in chemical synthesis to build desired molecules. Although alkylation of compounds be...
Precision Screening and Surgical Resection of Pan‐Cancer Using a Tandem‐Locked NIR‐II Fluorescent Probe with Optimized Activation Efficiency
Abstract The development of fluorescent probes for cancer detection and imaging that balance high sensitivity, precision, and broad applicability remains a signi...
Tertiary Phosphine Diversification via Photochemical P─C Chemoselective Cleavage of Phosphonium Salts
Abstract Differentially substituted phosphines are indispensable in medicines, materials, and catalysis, yet their customizable synthesis, traditionally depending on unstable P─H/hal...
Ultra‐Fast Self‐Powered Heterojunction Blue‐Light Photodetector Based on Boronate‐Ester‐Linked COF‐5
Abstract Covalent organic framework materials have recently garnered significant interest from the scientific community due to their fascinating properties that include highly ordere...
Regioselective Hydration of Terpenes with Cofactor‐Independent Carotenoid 1,2‐Hydratase
Abstract Terminally hydrated terpenes are highly sought‐after compounds in the flavor and fragrance industries. However, their selective synthesis remains a cons...
Chiral Tin‐Oxo Cluster Matrices with Fluorophore Embedment for Multichromatic Circularly Polarized Luminescence
Abstract Tin‐oxo clusters, characterized by their well‐defined chemical compositions and architectures, are multi‐metal aggregates composed of Sn‐oxide cores and...
A Homobimetallic Frustrated Lewis Pair Cobalt Catalyst for the Methanolysis of Hydrosilanes
Abstract The bimetallic Co(I)/Co(–I) complex [Co(CO) 2 (κ 3 ‐...
Antisolvent‐Bathing Strategy with Ultra‐Wide Processing Window for Making High‐efficiency Perovskite Solar Cells in Ambient Air
Abstract Most record‐efficiency perovskite solar cells rely on spin‐coating with antisolvent dripping, which is fundamentally incompatible with roll‐to‐roll (R2R...
Fe─N <sub>4</sub> ‐Anchored Carbon Layer Patched TiO <sub>2</sub> Cavities to Construct an “In‐Lattice Heterojunction” for Enhanced Photocatalytic Nitrogen Reduction Reactions
Abstract Efficient charge separation and carrier transfer are critical determinants of the performance of photocatalysts for nitrogen reduction reactions (NRR) w...
Bottom‐Up Regulation of Perovskite Growth and Energetics via Oligoether Functionalized Self‐Assembling Molecules for High‐Performance Solar Cells
Abstract Self‐assembling molecules (SAMs) are widely used as interfacial layers to optimize the surface properties of nickel oxides (NiO x...
Anionic Coordination‐Regulated Metal‐Organic Cages for Efficient CO <sub>2</sub> Photoreduction
Abstract Photocatalytic reduction of carbon dioxide (CO 2 ) provides a promising strategy for producing high‐value chemic...
Mathematical Double‐Matrix Switchable Homochiral Ferroelectric
Abstract Homochiral ferroelectrics have attracted increasing attention in recent years because of their distinctive chiroptical effects in contrast to ordinary f...
Doping Bulky Fluorinated Organic Anion to Construct Highly Efficient Anion‐π <sup>+</sup> Type Photosensitizers for Cancer Phototheranostics
Abstract Anion‐π + type photosensitizers with aggregation‐induced emission (AIE) feature have demonstrated promising pote...
Plasmon‐Ferroelectric Induced Multifield Coupling Effect Accelerates Charge Spatial Separation for Boosting Tandem Photoredox Catalysis
Abstract Integrating solar‐driven CO 2 reduction with organic oxidation is regarded as an ideal strategy for achieving ca...
Isotope Engineering of Tetraphenylethylene: Aggregate‐Dependent Enhancement of Luminescence Efficiency
Abstract Aggregation‐induced emission (AIE) luminogens, exemplified by tetraphenylethylene (TPE), exhibit enhanced fluorescence in aggregated states and have promising applications i...
Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol
Abstract These studies reveal the first structure of Clostridium acetobutylicum alcohol dehydrogenase (CaADH), a protein...
When Bigger is Better: Lanthanum Complexes of Bis(phenoxy‐amidine) FAlen Ligands as Unique Catalysts for the Isoselective Ring‐Opening Polymerization of Racemic β‐Lactones
Abstract Discrete yttrium and lanthanum complexes supported by new bis(phenoxy‐amidine) ligands have been prepared in high yields. Some of these so‐called FAlen...
Metal‐Responsive Up‐Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding
Abstract The stress‐responsive up‐regulation process is a sophisticated biological response to maintain cellular homeostasis. In intracellular anti‐oxidant syste...
Privileged Chiral Photocatalysts
Abstract Privileged chiral catalysts have transformed asymmetric synthesis, conferring generality to processes that are routinely leveraged in the construction o...
Donor Engineering for High Performance n‐Type OECT Materials with Exceptional Operational Stability
Abstract Donor–acceptor (D–A) conjugated polymeric mixed ionic–electronic conductors (PMIECs) have been widely used in organic electrochemical transistors (OECTs...
Macromolecule‐Driven Supramolecular Polymerization Induced by Crowding Effects
Abstract Macromolecular crowding plays a crucial role in biological systems by regulating dynamic processes, yet its effects in fully synthetic environments remain largely unexplored...
Dinuclear Au(0) Complex Supported by Tridentate P–Mg–P Ligands
Abstract Despite significant advances in gold chemistry, the synthesis and stabilization of gold centers in a low oxidation state, particularly dinuclear Au(0) species, remain a cons...
A Highly Crystalline 2D Conjugated Metal–Organic Framework for Superior Sodium Storage
Abstract Two‐dimensional conjugated metal–organic frameworks (2D c ‐MOFs) have emerged as promising electrode materials f...
Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP‐InsP <sub>4</sub> Isomers in Plant Signaling
Abstract Inositol pyrophosphates (PP‐InsPs) are highly phosphorylated signaling molecules that regulate diverse cellular processes, including phosphate homeostas...
Prolonging Exciton Diffusion Length via Modulating Aggregation Structures for Binary Organic Photovoltaics Approaching 20% Certified Efficiency
Abstract The performance of flexible all‐polymer organic photovoltaics (OPVs) constrained by low short‐circuit current density ( J...