Angewandte Chemie International Edition

Simultaneous Degradation‐Depolymerization of Bioderived Comb Copolymers

Abstract Poly(lactic acid) (PLA) is the most widely explored biodegradable alternative for polystyrene; however, its low toughness and glass transition temperature may limit its wide...

Frontispiece: Gypsum Gardens: Self‐Assembled Tubular Structures of Calcium Sulfate with Relevance for the Detection of Extraterrestrial Life

Frontispiece: Chemical Synthesis of Arabinogalactans from the <i>Mycobacterium tuberculosis</i> Cell Wall up to the 92‐mer and Structure–Conformation–Activity Relationship Studies

In Situ Tandem Synthesis of Charged Boron‐Oxo Clusters into Highly Ordered Architectures

Abstract The controlled assembly of multiple cationic and anionic clusters into well‐defined architectures remains one of the major challenges in chemistry. In t...

Toward Anode‐Free Sodium Metal Batteries: Engineering Metal Utilization from Excess to Zero

Abstract Sodium metal batteries (SMBs) with limited metal content or anode‑free configurations hold significant potential to mitigate safety risks associated with active sodium (Na)...

Interfacially Mineralized Magnetic Colloidal Gel with Microenvironment‐Triggered Disassembly for Interventional Treatment of Hepatocellular Carcinoma

Abstract Colloidal gels (CGs) are attractive carriers for functional nanoparticles (NPs) in biomedical applications. However, the current interfacial design of C...

Outside Back Cover: Low‐Spin W ^III ‐Triggered Triplet Spin‐Polarized Electron Delocalization of Tungsten Oxide for Photocatalytic Reduction of Uranium (Angew. Chem. Int. Ed. 48/2025)

Inside Back Cover: In Situ Tandem Synthesis of Charged Boron‐Oxo Clusters into Highly Ordered Architectures (Angew. Chem. Int. Ed. 48/2025)

Low‐Spin W ^III ‐Triggered Triplet Spin‐Polarized Electron Delocalization of Tungsten Oxide for Photocatalytic Reduction of Uranium

Abstract Solar‐light‐driven photocatalysis is a green and efficient technology to immobilize high‐toxic and radioactive uranium (U). However, a great challenge i...

Outside Front Cover: A High Modulus, Multi‐Stimuli Responsive, Interwoven Protein Network With Topologically Confined Micro‐Association (Angew. Chem. Int. Ed. 48/2025)

Magnetic and Peroxidase‐Specific Single‐Atom Nanozyme Through Cu‐Doping Engineering for Ultrasensitive and Visual Tumor Diagnosis

Abstract Designing single‐atom nanozymes (SAzymes) with superparamagnetism and peroxidase (POD)‐specific activity was still a challenge. In this research, we rep...

Correspondence on “Confinement of Polyiodides by Dual‐Functional Tetrazine Cathodes in Zn–I ₂ Batteries”

Abstract In a recent research article (doi.org/10.1002/anie.202507497), Chi, Huang, Qu et al. described a multifunctional cathode for Zn–I 2...

Inside Front Cover: Structure‐Oriented Metal‐Organic Framework Activation via Proximal Oligoalkyl Quaternary Ammonium Grafting Enhances Long‐Chain PFAS Sorption (Angew. Chem. Int. Ed. 48/2025)

Aluminum Exposure Impairs Electrochemically Measured Vesicular Storage and Exocytosis via Iron Homeostasis Dysregulation

Abstract Widespread human exposure to aluminum (Al) has raised increasing concerns about its effects on neuronal functions since Al 3+...

Symmetry Breaking and Hydrogen Bonding in Phthalimide Compounds Enable Efficient Room‐Temperature Circularly Polarized Phosphorescence in Solution

Abstract The development of purely organic chiral room temperature phosphorescence (RTP) emitters is attracting more and more attention. However, the key paramet...

Solvent‐ and Energy‐Free Solid‐State Strategy for Enzyme Encapsulation in ZIF

Abstract Conventional enzymes immobilization strategies within metal–organic frameworks (MOF) typically require solvents and energy, resulting in solvent residues, environmental poll...

Reductive Nitrogen Species Activation via Pulsed Electrolysis: Recent Advances and Future Prospects

Abstract The electrochemical reduction of nitrogen species offers a sustainable route to mitigate environmental nitrogen pollution while enabling the production of value‐added chemic...

Organophotoredox and Cobalt‐catalyzed 1,2‐Difunctionalization of Mono‐Donor Cyclopropanes

Abstract Selective functionalization of unactivated C─C and C─H bonds in mono‐donor cyclopropanes represents a significant yet challenging goal in organic synthesis. Although numerou...

In‐Situ Probing CO Activation in Sulfur‐Enhanced Paired Electrocatalysis for CO ₂ ‐to‐C ₂₊ Conversion with Alcohol Oxidation

Abstract In a world striving for sustainable energy, advanced electrocatalysts are pivotal to enabling efficient chemical transformations with minimal energy cos...

From Oxygen to Tellurium: The Impact of the Chalcogen on Nucleophilicities and Basicities of Isochalcogenourea Catalysts

Abstract Isochalcogenoureas (IChU) embedded in bi‐ or tricyclic ring systems have proven to be versatile Lewis base/nucleophilic catalysts that activate a wide range of electrophilic...

Enantioselective Synthesis of α‐Arylated Allene Ketones Through Sequential Bismuth(V)‐mediated Arylation and Organocatalytic Protonation

Abstract Triarylbismuth(V)‐mediated arylation represents an important approach for synthesizing a wide range of α‐arylated ketones and enol derivatives. Since the seminal work by Bar...

Sandwich‐Like Free‐Standing Covalent Organic Framework Anion Exchange Membranes for Water Electrolysis

Abstract Covalent organic frameworks (COFs) offer well‐defined pores for efficient ion transport but suffer from poor mechanical stability. Herein, a sandwich‐li...

Eccentrically Twisted and Helical Nanoarchitectonics by Sequence‐Defined Peptide‐π Conjugates

Abstract Peptide self‐assembly presents a powerful strategy for constructing chiral nanostructures with promising applications in biology and materials science....

Superbasic Anionic Calcium Alkyl Complexes: Templated Twofold Deprotonation of Benzene

Abstract Anionic calcium alkyl complexes have been synthesised through the reduction of ethylene by an anionic calcium hydride. The alkyl complexes are demonstra...

Mannich Cyclization of Bifunctional Hydroxylamines by Aza‐Kornblum–DeLaMare Rearrangement to Form Cyclopentyl <i>β</i> ‐Amino Esters

Abstract We report that readily accessible N ‐haloalkyl hydroxylamines serve as bifunctional imine surrogates for novel (...