Angewandte Chemie International Edition
Articles in this Issue
A General Strategy to Develop Intramolecular Spirocyclic Boron Dipyrromethene Fluorophores for Self‐Blinking Super‐Resolution Imaging
Abstract Intramolecular spirocyclic fluorophores, with their controllable on‐off switching, have enabled diverse stimuli‐responsive probes and serve as cornersto...
Metal‐Hydroxide‐Porphin Framework Membrane for Almost Perfectly Selective Li <sup>+</sup> Retention
Abstract Membrane separation of Li + from other ions, particularly alkaline ions, offers a green way toward direct lithiu...
A Picolyl‐Based Cys Caging/Uncaging Strategy Facilitates Protein Synthesis
Abstract Endowed with a reactive thiol group, cysteine (Cys) provides a versatile handle for site‐specific bioconjugation and serves as a cornerstone of chemical protein synthesis, p...
Novel <i>α</i> ‐KG/Fe(II)‐Dependent Dioxygenases Catalyzing C1 <i>β</i> ‐Hydroxylation and Construction of 5/7/6‐Skeleton of Highly Oxygenated Taxoids
Abstract Here, we report the discovery and functional characterization of one novel taxane C1 β ‐hydroxylase (...
In Situ Visualization of Lattice‐Coherent Phase Oscillations and Active Brownian Motion of a Copper Catalyst During Hydrogen Oxidation
Abstract Structural dynamics govern the catalytic activity of metal nanoparticles (NPs), yet their atomic‐scale mechanisms remain unclear. Using in situ transmis...
Pd─N <sub>4</sub> Sites in MOFs Modulate Oxygen Reduction Pathways for 100% Selective Photocatalytic CO <sub>2</sub> ‐to‐CH <sub>4</sub> Conversion from Oxygenated Flue Gas
Abstract Direct photocatalytic CO 2 reduction in flue gas is significantly challenged by the thermodynamically favored ox...
Asymmetric Structure‐Induced d‐Orbital Splitting Boosts Highly Active and Stable Li–CO <sub>2</sub> Batteries
Abstract Lithium‐carbon dioxide (Li‐CO 2 ) batteries provide an extremely feasible strategy for sustainable development a...
Miniature Photoenzyme Enables Organelle‐Specific Cellular Control via Deboronative Hydroxylation
Abstract Artificial photoenzymes hold transformative potential for in vitro biocatalysis, but their translation to live‐cell environments demands minimal cellula...
Anion‐Enriched Solvation Engineering of Ester‐Based Electrolytes for Sodium Metal Batteries at −40 °C
Abstract Sodium metal batteries (SMBs) are recognized for their high theoretical capacity, abundant availability, and low electrochemical potential. However, the...
Phase‐Transition Nanoparticles Enable Fluorescence Self‐Reporting for Close‐Loop Photodynamic Therapy
Abstract Photodynamic therapy (PDT) faces a fundamental limitation of the intrinsic energy utilization competition between fluorescence and reactive oxygen speci...
Organic Microemulsion Electrolytes for Advanced Metal Secondary Batteries
Abstract Current carbonate electrolytes encounter a bottleneck for high‐performance lithium rechargeable batteries due to their potential safety issues, narrow o...
Stereodivergent Alkylation of Unstrained C(sp <sup>3</sup> )─C(sp <sup>3</sup> ) Bonds
Abstract Asymmetric functionalization of C─C σ bond is a straightforward way to edit molecule backbones but heavily relies on strained rings. The related process with unstrained stru...
Molecular Design‐Enabled Pyridinium‐Based Metal Halide Glass Scintillators with Robust Glass‐Forming Ability and Tailorable Radioluminescence
Abstract Organic–inorganic hybrid metal halide (OIMH) glasses represent a promising class of functional materials due to their facile synthesis, high transparenc...
Reversible Sandwich‐Based Particle Nanoswitch for Continuous Protein Monitoring at Picomolar Concentrations with Automated Calibration
Abstract Continuous monitoring of specific proteins is essential for understanding the dynamics of biological systems and for enabling real‐time measurement‐and‐control strategies in...
Effective Coordination Promoted Carbene N─H Bond Insertion on Heterogeneous Cu Catalyst
Abstract In this study, we present a rationally designed Cu nanowire (NW) catalyst for carbene N─H bond insertion, addressing the challenges associated with highly coordinative aliph...
Recoverable Fluorination Accelerates Ring‐Opening Copolymerisation and Enables Post‐Polymerisation‐Modification of Polyesters
Abstract Fluorination of polymers is a powerful strategy to enhance chemical or material properties yet integrating these benefits into degradable polymers remai...
Chemical Reactions in Cellular Microenvironments Directed by Conjugated Polymers Toward Biomedical Advances
Abstract Conjugated polymers exhibit unique structural and optoelectronic properties, enabling precise modulation of chemical reactions within cellular microenvironments. This review...
Beyond van der Waals: Modular Identification of 2D Materials in Strongly Bonded Layered Crystals
Abstract Top‐down exfoliation of layered solids has revolutionized materials innovation by enabling unprecedented access to atomically thin architectures. To exp...
Tailoring Na⁺ Chelation Dynamics for Expedient Sulfur Redox Kinetics in Low‐Temperature Sodium–Sulfur Batteries
Abstract Sodium–sulfur (Na–S) batteries have attracted considerable attention due to their high theoretical energy density and the abundant natural availability of sodium and sulfur....
Tungstotellurate(VI)‐Based Nanocomposite Inhibits Breast Cancer Proliferation and Metastasis by Enhancing Cuproptosis and Apoptosis
Abstract Cuproptosis, characterized by the accumulation of copper (Cu) ions and mitochondrial respiration modulation, holds great potential in cancer therapy. As...
A Probe Design Strategy Based on Cholesterol‐Induced Differential Cellular Uptake for Cancer Cells Specific Penetration and Imaging
Abstract Cancer metastasis and postoperative recurrence continue to pose significant challenges in the treatment of advanced‐stage cancer, highlighting the urgent necessity for early...
Engineering Nanoscale Interfacial Solvation Inner‐Outer Configuration via Multi‐Group Synergy for Practical Zinc Batteries
Abstract Rational design of interfacial solvation structures in electric double layer (EDL) remains a critical challenge for aqueous zinc metal batteries (AZMBs)...
Remote Enantioselective Redox ε‐Alkylation of Copper Allylic Allenylidenes with Enals
Abstract The development of asymmetric functionalization at positions distant from the catalytic center—achieving high complexity, diversity, and stereocontrol—p...
A‐Site Cation‐Regulated <i>Operando</i> Restructuring of Cu‐Based Perovskite Oxides for Selective Carbon Monoxide Electroreduction
Abstract Understanding the correlation between surface catalytic motifs and electrochemical reaction pathways is crucial for the rational design of high‐performa...
Four Cytochrome P450 Enzymes Mediate Oxidation Cascades in the Biosynthesis of Cephalotane‐Type Diterpenoids
Abstract Cephalotane‐type diterpenoids, a class of natural products exclusively found in Cephalotaxus plants, are well kn...