Angewandte Chemie International Edition
Articles in this Issue
Outside Back Cover: Amide and Thioester Synthesis Via Oxidative Coupling of Alcohols with Amines or Thiols Using Alcohol Dehydrogenases (Angew. Chem. Int. Ed. 1/2026)
Inside Back Cover: Spatial Decoupling of Adsorption and Transformation Sites on Ag‐Cu Dual‐Single‐Atom Catalysts for Highly Selective Photocatalytic Nitrate‐to‐Ammonia Reduction (Angew. Chem. Int. Ed. 1/2026)
A Molecular Machine Directs the Synthesis of a Rotaxane
Abstract Preorganization by assembly or templating strategies is frequently used in the synthesis of rotaxanes. While these approaches have led to complex interlocked molecules, they...
Bypassing β‐Hydride Elimination: Excited‐State Pd‐Catalyzed C(sp <sup>3</sup> )–C(sp <sup>2</sup> ) Coupling at Room Temperature
Abstract Catalytic modification of C−H bonds using palladium is highly appealing, but transformations involving alkyl‐Pd(II) intermediates with...
Ring Strain‐Promoted Activation of Pyridines by a Saturated BSi <sub>2</sub> Cycle
Abstract Ring strain is a well‐established strategy to increase reactivity. Employing an elusive saturated BSi 2 ring mot...
Aquatic Environment Breaks the Size Confinement of the TiO <sub>2</sub> Anodes in Aqueous Batteries
Abstract The particle size of TiO 2 anodes is commonly believed to have a negative impact on their mechanical properties....
Modular Access to sp <sup>3</sup> ‐Rich Bicyclo[1.1.1]pentane Bioisosteres via Energy‐Transfer‐Mediated Carbene Insertion
Abstract Substituted bicyclo[1.1.1]pentanes (BCPs) are increasingly recognized as valuable sp 3...
A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery
Abstract Carbon monoxide (CO) has shown therapeutic potential across various diseases, including cancer. To enable controlled delivery, many CO‐releasing molecul...
Outside Front Cover: Regulating Promiscuous Catalysis via Substrate‐Induced Transient Assembly (Angew. Chem. Int. Ed. 1/2026)
Through Stronger Hindrance to Higher Reactivity: Influence of the Alkyl Chains on the Activation Energy of Ether Cleavage on Silicon
Abstract Reactivity in surface chemistry is often discussed in terms of the interaction between surface states and the functional groups of the reacting molecule...
The Combination of Chiral Assembly and Chiral Template Effects Boosts Circularly Polarized Luminescence of Perovskite Nanocrystals
Abstract Perovskite nanocrystals (PNCs) exhibiting circularly polarized luminescence (CPL) represent a promising class of materials for display and light communi...
Grafting Cell‐Penetrating Poly(disulfide)s to Substrates of Interest: Dynamic Covalent Bioconjugation for Traceless Delivery
Abstract Although increasingly understood and appreciated, thiol‐mediated uptake (TMU) remains underused because practical traceless tags that solve daily delive...
Simultaneously Enhancing NIR‐II Emission, Type‐I, and Type‐II Photosensitization Through Acceleration of Charge‐Separated‐State Formation for Tumor Phototheranostics
Abstract Phototheranostic agents with near‐infrared (NIR) excitation wavelengths offer significant promise for tumor imaging and therapy. However, due to the lim...
Solvent‐Controlled Supramolecular Polymerization and Morphology‐Depended Photoconductivity Modulation in a Squaraine‐Naphthalene Diimide‐Squaraine Bulk p/n Heterojunction
Abstract We designed a donor–acceptor–donor (D–A–D) molecule, TISQ , consisting of squaraine as the electron donor and na...
Homogenizing Self‐Assembled Monolayers via Covalent Organic Frameworks for Inverted Perovskite Solar Cells
Abstract Self‐assembled monolayers (SAMs) have emerged as promising hole transport layers (HTLs) in inverted perovskite solar cells (PSCs) due to their unique capability to modulate...
Spirosilanes Activate Gold(I)‐Catalysts in Cycloisomerization and Intermolecular Reactions
Abstract Gold‐catalyzed reactions have established as a powerful tool in organic synthesis, offering efficient pathways to construct diverse molecular structures and notably scaffold...
Defluoroalkylation of Trifluoromethane with Organolithium Reagents: Mechanism and Synthesis of Fluoroalkenes
Abstract Trifluoromethane (HCF 3 , HFC‐23) is a byproduct of fluoropolymer production that has limited applications. It i...
Dynamic Bonding Enabled Ambient‐Driven Motors
Abstract Harnessing ambient low‐density energy and converting it into macroscopic motion is a hallmark of living systems. However, artificial systems are often limited by high energy...
Bright and Color‐Tunable Circularly Polarized Excimer Emission from Pre‐Organized, Naphthalene Diimide Molecular Designs
Abstract Within the realm of organic materials, excimer emission has emerged as an efficient strategy for developing circularly polarized luminescence (CPL)‐acti...
Photoinduced Proton‐Cation Cascade Boosting Ion Intercalation Dynamics in Photo‐Assisted Zinc‐Ion Batteries
Abstract While photo‐assisted ion batteries represent a promising energy storage frontier—with light irradiation significantly improving performance—their develo...
Photoactivatable Hydrazone Photoswitches
Abstract Photoactivatable molecules enable on‐demand generation of active species via external light stimulation, allowing for precise spatiotemporal control ove...
Atroposelective Palladium‐Catalyzed γ‐C–H Olefination of BODIPYs
Abstract Enantioenriched BODIPYs have emerged as a class of exceptionally valuable fluorophores, distinguished by their remarkable chiroptical properties and versatile applications i...
<i>Acinetobacter baumannii</i> α2–6‐Legionaminyltransferase‐Catalyzed Synthesis Reveals Legionaminic Acid Form Selectivity by Antibodies in Pooled Human IgGs
Abstract Legionaminic acids (Legs) are prokaryote‐specific nine‐carbon acidic monosaccharides belonging to the nonulosonic acid (NulO) family. Various Leg forms...
Stereodivergent Access to C‐N Atropisomers via Phosphonium Salt‐Enabled Desymmetrizing Remote Cyclization/Aromatization Cascade
Abstract In this study, we describe a highly efficient organocatalytic enantiodivergent method for synthesizing C‐N axially chiral compounds via remote asymmetri...
One Collision – Two Heteroatoms: Gas‐Phase Preparation of Azasilabenzenes
Abstract Nature has long favored cyclic, particularly heterocyclic, molecules in the synthesis of key biomolecules. Silicon‐substituted hydrocarbons have gained...