Angewandte Chemie International Edition
Articles in this Issue
Engineering Isoquinoline‐derived Directing Template for Distal C5−H Functionalization of Bicyclic Aza‐arenes
Abstract Benzo‐fused mono‐ and di‐azines constitute privileged scaffolds in pharmaceuticals and functional materials; however, achieving site‐selective remote be...
Engineering Protein‐Based Nanofiltration Membranes with Sub‐Nanometer Pores via Amyloid‐Like Aggregation
Abstract Membrane proteins in biology achieve highly efficient selective molecular recognition and transmembrane transport by constructing sub‐nanometer channels...
Suppressing Alkyl Ammonium Deprotonation with Low‐pKa Solvent for Reproduceable and Stable High‐Efficiency Perovskite Solar Cells
Abstract Various passivation strategies have been explored to enhance the stability of the perovskite solar cells (PSCs). However, the chemical stability of passivators has received...
Single‐Atom‐Modulated Reactive Oxygen Species Generation and Network Crosslinking in Porphyrin‐Based Metallacages for Selective Photocatalysis
Abstract Precise control over the photocatalytic selectivity by single atoms is ubiquitous in natural systems but remains a formidable challenge for artificial p...
A Biocatalytic Platform for the Synthesis of Organofunctional Silanes and Siloxanes
Abstract Organofunctional silanes are highly useful reagents in material science, functioning as effective crosslinking agents and adhesion promoters. Traditiona...
Singlet Fission in Push–Pull <i>Para</i> ‐Azaquinodimethane Films under the Gaze of Time Resolved Optical and Magnetic Spectroscopy
Abstract In this study, a totally green synthetic protocol was employed to obtain four new donor–acceptor–donor para ‐aza...
A General Reverse Micelle‐Confined Strategy for the Facile Synthesis of 2D Conjugated MOF Colloids with Good Photothermal Properties
Abstract Micelle‐confined synthesis is a well‐established bottom‐up strategy for nanomaterials synthesis, offering precise synthetic control and inherent dispers...
Nanoparticle‐Based Tolerogenic Vaccines: Next‐Generation Strategies for Autoimmune and Allergic Disease Therapies
Abstract The concurrent rise of autoimmune diseases, which affect nearly 10% of the global population, along with allergic conditions such as asthma, food allergy, and atopic disease...
Optical Vortex‐Induced Chiral Nanotubes of Tetra(4‐sulfonatophenyl)porphyrin for Enantioselective Catalysis of Dihydroxy Phenylalanine
Abstract Achieving symmetry breaking and controlling the initial chirality of molecular assemblies are crucial for understanding the origin of chirality in nature. However, weak chir...
Semiconducting Borophene Realized via Hydrogenation‐Driven Structural Reconstruction
Abstract Hydrogenation provides a robust approach to both dramatically improve borophene's ambient stability and induce semiconducting behavior—two essential req...
Directed Crystallization: Engineering Facet‐Specific High‐Entropy Alloy Nanocatalysts Toward Advanced Zinc‐Air Batteries
Abstract Precisely engineering crystallographic facets and dimensional architectures at the atomic scale is critical for unleashing the catalytic efficiency of h...
Formal [4+3] Bridged Cyclization of Pyridines/Isoquinolines with Vinylcarbenes via Dearomatized Oxazinopyridine Intermediates
Abstract The direct dearomative cycloaddition of pyridines provides a powerful tool to construct medicinally important azabicyclic scaffolds. However, existing methods are limited to...
Iron‐Catalyzed Enantioselective Deoxygenative Addition of Propargyl, Allyl, and Benzyl Alcohols to Cyclic <i>N</i> ‐Sulfonyl α‐Ketiminoesters Mediated by Visible Light
Abstract Asymmetric photomediated iron catalysis remains underdeveloped; up to now, only limited successful examples have been reported. Herein, we describe an i...
Late‐stage Tyrosine <i>ortho</i> ‐C(sp <sup>2</sup> )‐H Alkenylation for Macrocyclic Peptide SuFEx Proximity Labeling and Targeted Degradation
Abstract Cyclic peptides hold great promise in drug discovery due to their conformational stability, proteolytic resistance, and ability to disrupt protein–prote...
Interface‐Regulated Orbital Coupling Enables Nucleophilic Carbon Assembly Pathways in Electrochemical CO <sub>2</sub> Conversion
Abstract Achieving selective and durable CO 2 electroreduction to ethanol remains challenging due to the instability of C...
In Cellulo Multistep Synthesis of Antitumor Zwitterionic Heterocycles Triggered by Cancer‐Specific Acrolein
Abstract Zwitterionic heterocycles hold significant therapeutic potential; however, their application is often hindered by poor membrane permeability and limited...
Directional Electron Transfer in Island‐Sea Structured Contact‐Electro‐Catalysis Enables Cascade Defluorination of PFAS
Abstract The exceptional stability of C─F bonds in per‐ and polyfluoroalkyl substances (PFAS) impedes their activation and degradation through conventional redox...
Concurrently Maximize CO <sub>2</sub> RR and Minimize HER: A Dual Catalytic Active Site Approach for Ampere‐Level CO <sub>2</sub> ‐to‐CO Electrolysis
Abstract The practical application of electrocatalytic CO 2 reduction reaction (CO 2...
Unlocking Dual‐Pathway Low‐Potential Aldehyde Oxidation on Chromium‐Doped Copper Catalysts
Abstract The low‐potential aldehyde oxidation reaction (LPAOR) is emerging as a pivotal anodic strategy in hybrid water electrolysis and biomass fuel cell system...
Controllable C─N Coupling Toward Efficient Urea Electrosynthesis via Spin State Modulation on Fe Catalysts
Abstract The co‐electrolysis of CO 2 and nitrate (NO 3 − ) pr...
Nonheme Fe Enzyme‐Catalyzed Enantiodivergent Nitrogen Migration: Directed Evolution and Computational Study of Isopenicillin N Synthases for Biocatalytic Synthesis of Arylglycines
Abstract We describe the reprogramming and directed evolution of nonheme Fe enzyme isopenicillin N synthase (IPNS) as an efficient biocatalyst for 1,3‐nitrogen m...
Interfacial Synergy in Ni <sub>x</sub> Mg <sub>1‐x</sub> O/CeO <sub>2</sub> for Efficient Ammonia Decomposition
Abstract Hydrogen production via ammonia decomposition presents a promising way to solve the difficulties of hydrogen storage and transportation. Ni‐based cataly...
Exploring the World of Double Nanohoops
Abstract Conjugated nanohoops have become highly relevant compounds based on their unique conjugation, structural, optoelectronic, and morphological properties. Recent synthetic effo...