Angewandte Chemie International Edition
Articles in this Issue
A Convergent Hybrid Gram‐Scale Synthesis of Tirzepatide: Tangential Flow Filtration Assisted Native Chemical Ligation‐Desulfurization Approach
Abstract The development of scalable and efficient manufacturing of high‐volume complex synthetic peptides and proteins, like tirzepatide (TZP, 1), faces major hurdles due to the lim...
Apoptosis‐Amplified Intracellular Paclitaxel Nanoparticle Formation Enhances Microtubule Aggregation and PANoptosis
Abstract The clinical efficacy of paclitaxel is limited by systemic toxicity at high doses and poor cellular uptake of nanoformulations. Intracellular paclitaxel nanostructure format...
Localization of Photothermal Effect Enables Impetus Transition from Heating to Solar Energy for Liquid‐Phase Reaction with Superior Productivity
Abstract Thermally driven reactions are fundamental but energy‐intensive for chemical production. Solar‐induced photothermal effect is anticipated to thoroughly...
Metallopolymer Films of a Manganese(II) Chelate with Hexadentate Ligand for High‐Performance Electrochromism
Abstract To achieve high‐performance electrochromism, one of the most critical challenge is how to attain a transparent state. For this purpose, we elaborately d...
Bidirectional Photoregulated Chromism in Pyridinium Derivatives via Secondary Excitation‐Driven Electron Transfer
Abstract The key challenge for photochromic pyridinium derivatives is the difficulty in precisely modulating their reverse process. To overcome this limitation,...
Dipoles Effect in Fe–N–C Catalyst by High‐Energy p Orbitals for Enhanced Acidic Oxygen Reduction Reaction
Abstract Tailoring the coordination sphere of the metal atoms represents a highly promising strategy to modulate Fe single‐atom catalysts. However, modifications...
Amorphization Strategy to Circumvent the Oxo Wall for Generating Active Co(IV)═O Species in Fenton‐Like Reactions
Abstract High‐valent Co(IV)═O species have garnered significant attention as a promising non‐radical reactive species. However, their selective generation encoun...
Boosting Array‐based Diagnosis of Urinary Tract Infections via a Heterobifunctional Bridge‐Driven Strategy
Abstract Array‐based sensing platforms have witnessed significant progress in recent years, demonstrating considerable potential for high‐throughput and multiple...
Backbone Asymmetry Modification in Amphipathic Conjugated Polymers Enables Record n‐Type Organic Thermoelectrics
Abstract Achieving high‐performance n‐type organic thermoelectrics (OTEs) has lagged behind p‐type counterparts due to limited electrical conductivity and power...
Building Topological‐Disordered High‐Entropy Amorphous Oxides for Adaptive Compensation During Alternating CO <sub>2</sub> Redox Cycling
Abstract Material fatigue from alternating structural evolution degrades electrochemical performance through local collapse and deactivation, with the key challe...
Unimolecular Micellization Strategy for Achieving NIR‐II Excited Fluorophores with Enhanced Brightness in Aqueous Media
Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II) enables deep‐tissue visualization with high spatial–temporal resolution. Developing mol...
Rationally Tailoring Simple Non‐Fused Ring Electron Acceptors Toward Zwitterionic Interlayers for Organic Photovoltaics: The Effect of Synergetic Sidechains Engineering
Abstract Advancing organic solar cells (OSCs) require simultaneous progress in organic semiconductors for both active layers and interlayers. The disparate electronic and structural...
Inside Front Cover: NADH Mimic‐Decorated Coordination Capsules for Biomimetic Capture of NO and Electrocatalytic Reduction to NH <sub>3</sub> (Angew. Chem. Int. Ed. 6/2026)
Potential‐Tailored Aryl–Sodium Reagent with Moderate Ionic Binding Strength Enables Precise yet Fast Hard Carbon Presodiation
Abstract Hard carbon (HC) is a promising anode for sodium‐ion batteries (SIBs), but coal‐derived HCs often exhibit low reversible capacity and poor initial Coulo...
Dual Co/Photoredox‐Catalyzed Regio‐ and Stereoselective Synthesis of Highly Functional 1,3‐Dienes
Abstract A dual Co/photoredox catalytic coupling of 1,3‐enynes and α,ß‐unsaturated aliphatic aldehydes and ketones has been developed that creates access to highly functional 1,3‐die...
Outside Back Cover: Thiosulfonate‐Derived BODIPY “Stick and Glue” Strategy for Fluorescent Thiol Labeling (Angew. Chem. Int. Ed. 6/2026)
Chemical Synthesis of <i>Pseudomonas aeruginosa</i> , <i>Staphylococcus aureus</i> , and <i>Acinetobacter baumannii</i> Capsular Polysaccharide Fragments as Leads for Cross‐Protection
Abstract Pseudomonas aeruginosa and Staphylococcus aureus are listed by the World Health Organization...
Activity Breakthrough in CO <sub>2</sub> Photoreduction to C <sub>2</sub> H <sub>6</sub> via Accelerated Electron Accumulation from H <sub>2</sub> O Photooxidation to H <sub>2</sub> O <sub>2</sub>
Abstract Solar‐driven CO 2 reduction suffers from severe hole accumulation and inefficient electron utilization due to th...
Ultralow‐Temperature Redispersion of Platinum Nanoparticle Catalysts
Abstract Sintering is one of the major causes of catalyst deactivation, which requires redispersion to restore catalytic activity. However, conventional redisper...
Thiosulfonate‐Derived BODIPY “Stick and Glue” Strategy for Fluorescent Thiol Labeling
Abstract Fluorescent thiol labeling is a powerful technique for investigating peptide and protein functions, interactions, and cellular localization, offering minimal structural disr...
Strongly Electron‐Accepting Lattice Oxygen of CeO <sub>2</sub> for Highly Efficient Dimethyl Carbonate Synthesis from CO <sub>2</sub> and Methanol
Abstract Converting CO 2 and green methanol to dimethyl carbonate (DMC) has both theoretical and practical value in carbo...
Non‐Radical Photocured 3D Printing of Liquid Crystal Elastomers
Abstract Digital light processing (DLP) of liquid crystal elastomers (LCEs) enables the fabrication of complex architectures for soft robotics and energy‐dissipative devices. However...
Stereospecific Transition‐Metal‐Free Alkylation of Chiral Non‐Racemic Secondary Tosylates with Cyanohydrins: Convenient Access to Enantiomerically Enriched α‐Tertiary Ketones
Abstract A novel stereospecific, transition‐metal‐free alkylation of cyanohydrins with enantiomerically enriched secondary tosylates is described. This method en...
A Fluorine‐Free Chaotropic Electrolyte Promoting Zinc Peroxide Chemistry for Non‐Alkaline Zinc–Air Batteries
Abstract Rechargeable non‐alkaline zinc–air batteries (ZABs) based on highly reversible zinc peroxide chemistry offer high energy density and superior stability...
Chiral Gadolinium Halides with Narrow Ultraviolet B Circularly Polarized Luminescence
Abstract Circularly polarized luminescence (CPL) in the ultraviolet B (UVB) region holds great potential applications in asymmetric catalysis, enantioselective p...