Angewandte Chemie International Edition

GRP78 Selective Inhibitors From a Direct‐to‐Biology Strategy

ABSTRACT Because cancer cells have heightened protein homeostasis (proteostasis) requirements, there is interest in targeting proteostasis machinery, including t...

Integrating Dissociating Stators and Conducting Rotors Within an Amphidynamic COF‐Based Solid‐State Polymer Electrolyte for Rapid and Consecutive Li ⁺ Transport

ABSTRACT Solvent‐free solid polymer electrolytes (SPEs) suffer from sluggish and discontinuous Li + transport. Although h...

Catalytic ROS‐Amplifying Self‐Immolative Linkers Enable Carrier‐Free Prodrugs for Refractory Tumors

ABSTRACT Redox‐buffering systems in tumors heighten chemoresistance, yet most ROS‐responsive linkers used in prodrug design consume oxidants, exhibit limited sensitivity to endogenou...

Boosting Alkaline Oxygen Evolution Kinetics by Tailoring the Noncovalent Interaction on CoOOH

ABSTRACT Understanding the effect of noncovalent interactions of intermediates at the polarized catalyst‐electrolyte interface is key to improving the kinetics o...

Site‐Selective B─H Activation via HAT Toward Xanthyl‐ <i>closo</i> ‐Carboranes as Bench‐Stable Precursors of Organosulfur Boron Clusters

ABSTRACT In this work, a light mediated direct regioselective B─H functionalization to afford unexplored xanthyl‐ closo ‐...

Molecularly Engineered Robust Polyelectrolyte for Continuous CO ₂ Electroreduction to Pure Formic Acid

ABSTRACT Electrocatalytic CO 2 conversion to liquid fuels requires coordinated advances in catalysis and product isolatio...

Monitoring Redox Pathways and Performance Limitations in Lithium‐Sulfur Batteries Using In Situ ^7/6 Li and ³³ S NMR Spectroscopies

ABSTRACT Lithium‐sulfur (Li‐S) batteries offer high capacity and reduced costs in comparison to the traditional lithium‐ion systems. However, the complex series...

Proximity‐Induced Transfer of a Mass Tag Enables Direct Profiling of Active Matrix Metalloproteases

ABSTRACT Conventional activity‐based probes in activity‐based protein profiling (ABPP) require enrichment or reporter tags for detection, which limits sensitivity and multiplexing. H...

Outside Front Cover: Oxidation State Determines Solvent Structure Around a Manganese–Vanadium Polyoxometalate Water‐Oxidation Catalyst (Angew. Chem. Int. Ed. 24/2026)

Inside Back Cover: <i>o</i> ‐Terphenyl‐Based Family of Conjugated Macrocycles: Selective Recognition of Phenylalanine in Water and Interaction With Insulin (Angew. Chem. Int. Ed. 24/2026)

Let There be Light! Light as an Engine and Regulator in Synthetic Cells

ABSTRACT Synthetic cells, assembled from defined molecular components, are designed to mimic the features, form, and function of living cells. Light has emerged as a uniquely precise...

Oxidation State Determines Solvent Structure Around a Manganese–Vanadium Polyoxometalate Water‐Oxidation Catalyst

ABSTRACT Understanding how microsolvation influences the reactivity and stability of molecular water‐oxidation catalysts remains a central challenge in artificia...

Alcohol‐Directed Carboamination of Conjugated Enynes

ABSTRACT We report a Pd‐catalyzed carboamination of conjugated enynes for the direct synthesis of functionalized allenic amines. The reaction proceeds through a selective 1,4‐couplin...