Angewandte Chemie International Edition
Articles in this Issue
Interfacial Proton‐Coupled Electron Transfer Reverses Water Inhibition for Selective 5‐hydroxymethylfurfural Hydrogenation
ABSTRACT The selective aqueous hydrogenation of 5‐hydroxymethylfurfural (HMF) to 2,5‐bis(hydroxymethyl)furan (BHMF) is pivotal for biomass valorization. While na...
Rational Formulation of Ether‐Lactone Electrolytes for Safe and Sustainable Ni‐Rich Lithium‐Ion Batteries
ABSTRACT This study reports the formulation of innovative electrolytes designed to improve safety, sustainability, and compatibility with LiNi...
Engineering Ag <sub>6</sub> Cluster‐Based Donor–Acceptor Heterojunctions Into Hydrogen‐Bonded Organic Frameworks for Photocatalytic H <sub>2</sub> O <sub>2</sub> Production
ABSTRACT Atomically precise coinage metal nanoclusters possess well‐defined structures and distinctive optoelectronic properties. However, their assembly through...
Solvent–Anion Counterpoised Electrolyte Enables High‐Rate Magnesium Metal Batteries
ABSTRACT Magnesium batteries are compelling post‐lithium energy storage candidates but suffer from sluggish charge transfer kinetics, fundamentally restricted by...
Isomeric Nonpolar Amino Acid–Derived Metal–Organic Frameworks for Xenon/Krypton Separation
ABSTRACT Efficient xenon/krypton separation remains challenging due to their similar physicochemical properties. Herein, we demonstrate that ligand isomerism can...
Luminescent Donor‐Acceptor Radical With Propeller Chirality: Bright and Photostable Red Circularly Polarized Luminescence and Whispering Gallery Mode Resonance
ABSTRACT Luminescent radicals are an emerging class of materials for organic electronics, bioimaging, and quantum applications. Circularly polarized luminescence...
Catalyst‐Free, Divergent Cysteine Modification via Indole Isocyanide Photochemistry
ABSTRACT Chemoselective cysteine modification is pivotal for chemical biology and drug discovery. While photochemical strategies offer spatiotemporal control, most current methods re...
High‐Performance Infrared Nonlinear Optical Crystals Discovery Guided by High‐Throughput Computation, Machine Learning, and Experimental Verification
ABSTRACT Infrared nonlinear optical (NLO) materials are essential for laser and photonic technologies, limited by fragmented material systems, lengthy developmen...
1,4‐Digermacyclopenta‐1,3‐diene: Continuous Cyclic σ*–π Delocalization Enables Aromatic Stabilization in a Heavy‐Element 4π System
ABSTRACT Aromaticity in heavy‐element systems can arise from unconventional modes of cyclic electron delocalization that are not accessible in lighter‐element fr...
Sodiophilic Hosts With Pseudocapacitive Kinetics for Robust Anode‐Free Sodium Metal Batteries
ABSTRACT Anode‐free sodium metal batteries (AFSMBs) promise high energy density and simplified fabrication, yet require repeated sodium nucleation on the current...
Boosted Durability and Diffusion Kinetics of High‐Potential Azopyridines for Aqueous Organic Flow Batteries
ABSTRACT High‐potential organic redox‐active molecules are crucial for high‐energy‐density aqueous organic flow batteries (AOFBs). Azopyridine (AZO) derivatives...
Topology‐Driven Conformational Constraint Enables High‐Temperature Organic Phosphorescence
ABSTRACT Achieving organic phosphorescence that remains stable at elevated temperatures is challenging because thermally activated molecular motions typically accelerate non‐radiativ...
In Situ Interfacial Polymerization Enabling a Dual‐Anchor Surface Binding Interlayer for Efficient and Stable Inverted Perovskite Solar Cells
ABSTRACT Surface defects such as iodine vacancies initiate lattice degradation via I − migration and proton transfer, res...
Electronegativity Adaption Approach for Solar‐Blind UV Birefringent Crystals With Ultrawide Bandgaps
ABSTRACT Birefringent crystals are essential for modern optics for their ability to modulate light polarization. The steretochemically active lone‐pair (SCALP) e...
Highly Crystalline and Porous Borocarbonitrides as Metal‐Free Catalysts for Boosted N‐Heterocycle Dehydrogenation
ABSTRACT Safe and efficient hydrogen storage is pivotal for enabling a clean hydrogen economy. Liquid organic hydrogen carriers (LOHCs) offer a practical solutio...
Expanded Gene Targeting in RNA Hacking With G‐Tract‐Supply Staple Oligomers
ABSTRACT RNA hacking (RNAh) is a gene regulation technology that employs a short oligonucleotide, termed a Staple oligomer, to induce the formation of RNA G‐quadruplex structures on...
Photo‐click Proteolysis‐Targeting Chimeras Enable Intracellular Generation of PROTACs for Precise Dual Protein Degradation
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are an emerging therapeutic modality via targeted protein degradation, but plagued by concerns about systemic t...
Integrative, Orientational Self‐Sorting at the Four‐Crossing Level in Molecular Knots and Links
ABSTRACT Low‐symmetry mechanically interlocked molecules (MIMs) remain challenging targets because of their anisotropic structures and synthetic complexity. We d...
Two‐Dimensional Mesoporous Tungsten Oxynitride/Carbon Nanosheets: Enabling High‐Performance Lithium‐Sulfur Batteries
ABSTRACT Lithium‐sulfur batteries (LSBs) hold great promise as next‐generation energy storage devices, owing to their ultrahigh theoretical energy density (2600 ...
High‐Entropy Tailored UCl <sub>3</sub> ‐Type Halides With Enhanced Ionic Conduction and Stability for All‐Solid‐State Sodium Batteries
ABSTRACT Designing advanced halide‐based solid electrolytes (SEs) combining high ionic conductivity and exceptional (electro)chemical stability is crucial for al...
Recent Trends in Metabolomics by NMR Spectroscopy
ABSTRACT This review is an update of our previous contribution published in Angewandte Chemie in January 2019 and provide...
Sub‐Nanometer PtSn Interlayer Tuning Ligand and Strain Effects Boosts Oxygen Reduction Electrocatalysis
ABSTRACT The integration of ligand and strain effects in core/shell architectures offers a compelling avenue for boosting the catalytic efficiency of noble metal...
A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation
ABSTRACT l ‐(+)‐Muscarine is a widespread fatal toxin produced by various mushrooms that pose a severe threat to human health when they are m...
Outside Back Cover: Let There be Light! Light as an Engine and Regulator in Synthetic Cells (Angew. Chem. Int. Ed. 24/2026)
Nano‐G <sub>s</sub> Protein Peptidomimetics: Rational Design of Gα C‐Terminus‐Derived Peptides Mimicking Key Components of G <sub>s</sub> ‐β <sub>2</sub> AR Interactions
ABSTRACT G protein‐coupled receptors (GPCRs) are involved in most human physiological processes and one of the largest families of approved drug‐targeted protein...