Angewandte Chemie International Edition
Articles in this Issue
Formation Energy‐Dominated AB‐Stacking Structure Promotes Metal‐Covalent Organic Frameworks for High‐Performance Dual‐Ion Storage Potassium‐Ion Batteries
ABSTRACT The long‐range AA‐stacking structures present in most covalent organic frameworks (COFs) result in poor utilization of redox‐active sites and suboptimal...
Dearomative [3,3]‐Claisen Rearrangement of 2‐Indolyl Alcohols: An Efficient and General Protocol for Synthesizing 3,3‐Disubstituted Indolines and Related Indole Alkaloids
ABSTRACT Dearomative reactions of indoles have long been a focal point of research in organic synthesis due to their ability to transform planar molecules into t...
Expanding High‐Fidelity Multiplexing in Ultrasensitive Single‐Molecule Protein Detection via Proximity Barcoding
ABSTRACT The human proteome presents a vast information reservoir for basic and diagnostics research, yet the low abundances of many proteins in biofluids pose an analytical challeng...
Spatial Evolution of Coke in ZSM‐5 Catalysts During Methanol‐to‐Hydrocarbons Conversion Revealed by In Situ X‐Ray Photoelectron Spectroscopy
ABSTRACT Along with assessing chemical pathways, understanding the spatial evolution of deactivating coke species in zeolites is essential for enhancing their ca...
3‐Deoxy‐3‐Fluoro Mannuronic Acid Alginates: Stereoselective Automated Synthesis and Conformational Behaviour
ABSTRACT Fluorination is a powerful strategy for the editing of glycans, creating bespoke tools to probe carbohydrate‐protein recognition and processing. Positio...
Lewis‐Base Coordination Enables Highly Dispersed Pt Cocatalyst on Pyrene‐Based MOFs for Enhanced Photocatalytic Hydrogen Evolution
ABSTRACT Rationally optimizing the coordination structures of Pt‐based cocatalysts to concurrently achieve enhanced charge separation/transfer and lowered reacti...
Multicolor and Attenuated Light Intensity Responses in Protein Hydrogels Arising from Photoregulated Crosslink Dynamics
ABSTRACT Light‐responsive hydrogels enable noninvasive, precise, remote control over material properties with great biocompatibility, yet achieving multicolor addressability and dyna...
Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration
ABSTRACT Nitro compounds are central to synthetic chemistry, yet mild and selective biocatalytic routes to these motifs remain elusive. We report an enzymatic st...
Synthesis of Cyclopropene‐Modified Fatty Acids Allows Single‐Cell Quantification of Uptake by Immune Cells
ABSTRACT Immune cell activity is strongly influenced by the nutrients present during activation. The effects of specific fatty acids (FAs) can be particularly complex, with them exer...
Water Radiolysis Enables CO <sub>2</sub> ‐Activated Radical Recycling of Spent Lithium‐Ion Cathodes
ABSTRACT Conventional recycling of spent lithium‐ion batteries (LIBs) relies on energy‐intensive and complex processes that hinder sustainability. Here, we repor...
Dimensional Isomerism in COFs Enabled by Spirobifluorene Substitution for Enhanced Photocatalytic CO <sub>2</sub> Reduction
ABSTRACT The concept of dimensional isomerism—covalent organic frameworks (COFs) constructed from identical molecular precursors but forming structures of differ...
Tuning Reaction Pathways via Symmetric Fluorination Enables High‐Temperature and High‐Voltage Electrolytes
ABSTRACT Ni‐rich layered oxide cathodes deliver high capacity, but they suffer from severe interfacial instability and thermal safety risks when operated at high...
Outside Back Cover: Tissue Heterogeneity‐Driven Parallel Acquisition for High‐Coverage MS/MS Imaging of Lipids (Angew. Chem. Int. Ed. 31/2026)
Lithium‐Germanium Alloy Interfaces for Efficient Low‐Pressure Ammonia Synthesis
ABSTRACT The lithium‐mediated nitrogen reduction reaction (Li‐NRR) offers a sustainable pathway for ammonia synthesis, providing a viable alternative to the ener...
Oxidative PCET‐Triggered Benzylic C─H Iminolactonization via 1,5‐HAT/Cyclization Enabled by Cage‐Confined Photocatalysis
ABSTRACT We present a visible‐light‐driven photocatalytic platform based on a photosensitive metal–organic cage (PMOC), which enables selective recognition and activation of amidyl N...
Synergistic Donor‐Acceptor Effect in Conductive Covalent Organic Frameworks of Polyphthalocyanines for Aqueous Zn–I <sub>2</sub> Batteries
ABSTRACT The development of materials with sufficient electrical conductivity and electroactivity is crucial for advancing their application in energy storage; h...
Mitochondria‐Targeting Iridium(III) Complexes Induce PANoptosis and Ferroptosis for Boosting Chemoimmunotherapy Against Immune‐Desert Colorectal Cancer
ABSTRACT Over 80% of colorectal cancer (CRC) cases are classified as microsatellite stable (MSS), a subtype characterized by an immunosuppressive tumor microenvi...
Single‐Molecule Additive Integrating Na‐Ion Reservoir, Cosolvent, and Diluent Functions for Low‐Temperature Na‐Ion Batteries
ABSTRACT Na‐ion batteries hold great promise for low‐temperature energy storage, but their performance is severely constrained by Na‐ion loss, electrolyte freezi...
Redirecting a Native Ene‐Reductase Toward Desaturation With Reverse Enantioselectivity
ABSTRACT Chiral enones are valuable motifs in synthetic intermediates and bioactive molecules, driving significant interest in biocatalysis. Although recent enzy...
BN Analogue of Butadiyne: A B─B‐Bonded sp–sp Diboron(2) Species and Its Desymmetrization
ABSTRACT In contrast to our earlier contribution on BN analogue of butadiyne featuring a conjugated B≡N─N≡B motif, we report here an alternative and distinct iso...
Outside Front Cover: Meso‐Strap Engineering of Aromaticity Redistribution in Porphyrinoids (Angew. Chem. Int. Ed. 31/2026)
Meso‐Strap Engineering of Aromaticity Redistribution in Porphyrinoids
ABSTRACT Porphyrins possess one of the most robust aromatic circuits in chemistry, and even highly distorted derivatives preserve the intrinsic [18]π aromatic fr...
A Universal Nucleoside‐to‐Nucleoside‐5′‐Triphosphate Enzyme Cascade Driven by Polyphosphate
ABSTRACT Nucleoside‐5′‐triphosphates (NTPs) are important building blocks for nucleic acids, but the efficiency of their chemical synthesis is limited by the low...
Nature‐Inspired Organic–Inorganic Hybridization Enables High‐Temperature and Multicolor Organic Phosphorescence
ABSTRACT Organic room‐temperature phosphorescence (RTP) has shown diverse practical applications; however, most organic RTP materials exhibit poor thermal resist...
Tissue Heterogeneity‐Driven Parallel Acquisition for High‐Coverage MS/MS Imaging of Lipids
ABSTRACT Elucidating tissue architecture and function necessitates lipid analysis that is both spatially comprehensive and achieved at high resolution while main...