Circulation
Articles in this Issue
Abstract 4346878: Comparison of Intra-coronary and Intra-aortic Pressure Recordings for Coronary Wave Intensity Analysis
Background: Coronary wave intensity analysis (WIA) provides a mechanistic view of coronary hemodynamics and has been increasingly used to phenotype coronary microvascular disease (...
Abstract 4367160: Guideline-Directed Medical Therapy Utilization Pattern in Patients with Peripartum Cardiomyopathy
Background: Guideline-directed medical therapy (GDMT) is recommended for the management of peripartum cardiomyopathy (PPCM). However, real-world evidence evaluating adherence to th...
Abstract 4360745: Multimodal Stress Testing and Morphologic Predictors of Ischemia in Anomalous Aortic Origin of a Coronary Artery
Background: Anomalous aortic origin of a coronary artery (AAOCA) is associated with myocardial ischemia (MI) and sudden cardiac death. Symptoms, positive stress tests, and presence...
Abstract 4368394: Comprehensive Phenotypic Characterization of Late Gadolinium Enhancement Improves Sudden Cardiac Death Risk Stratification in Nonischemic Dilated Cardiomyopathy
Background: Late gadolinium enhancement (LGE) is an established predictor of sudden cardiac death (SCD) in nonischemic dilated cardiomyopathy (DCM). However, the prognostic value o...
Abstract 4342084: Impact of Social Vulnerability on Cardiovascular Disease Outcomes Among Medicare Beneficiaries in the United States: A Three-Year Retrospective Analysis
Introduction: Cardiovascular disease (CVD) is a major cause of morbidity and mortality among older adults in the U.S. The Social Vulnerability Index (SVI), developed by the Centers...
Abstract 4368726: WHEN THE LIVER POINTS TO THE HEART: A RARE PRESENTATION OF SINUS OF VALSALVA RUPTURE
Introduction/Background: Sinus of Valsalva aneurysms are very rare congenital heart disease. Most cases of ruptured sinus of Valsalva aneurysms (RSVA) are associated with other con...
Abstract 4367061: Assessing Cardiovascular Risk in Patients with New Onset Diabetes After Statin Initiation
Background: Coronary artery disease (CAD) remains a leading cause of death in the United States. Cholesterol-lowering medications such as statins are key to reducing mortality and...
Abstract 4367138: Impact of Rural and Non-Rural Status on Congenital Heart Disease Healthcare Utilization and Outcomes
Introduction/Background: Congenital heart disease (CHD) is the leading cause of birth defects in the United States and contributes to billions of dollars in healthcare resource uti...
Abstract 4361672: Race does not influence the efficacy and safety of mineralocorticoid-receptor antagonists in heart failure: An individual-participant data meta-analysis of 4 trials
Introduction: There are concerns that renin-angiotensin system inhibitors are less effective in Black patients than non-Black patients with heart failure (HF). We have tested wheth...
Abstract 4366000: Association of Albuminuria with Cognition in Midlife: The CARDIA study
Background: Chronic kidney disease (CKD) has been associated with late-life cognitive decline. We aim to evaluate whether an early marker of kidney damage, measured by urinary albu...
Abstract 4342257: Beyond Heritability: Multimodal AI Integrating Imaging and Genetics Enables Population-Scale Precision Coronary Artery Disease Risk Prediction
Introduction: Identifying asymptomatic individuals and treating them based on underlying risk is a key challenge in preventing coronary artery disease (CAD). Genetic risk scores an...
Abstract 4364123: Impact Of Transition To An Acute Care Cardiology Inpatient Model
Background: Improved survival and healthcare system changes have led to increasing complexity of the typical hospitalized pediatric patient. This has led to the development of inpa...
Abstract 4365153: Dysregulated Lactate Metabolism in Cardiomyocytes Drives Immune Checkpoint Inhibitor- Associated Myocarditis
Introduction: Immunotherapy have significantly improved cancer patient survival，but cardiovascular diseases increasingly contribute to mortality in these patients. Although PD-1 i...
Abstract 4363044: A single-cell atlas of the human PAH lung identifies ITGA9 as a candidate regulator of fibroblast activation and vascular remodeling
Pulmonary arterial hypertension (PAH) is marked by progressive vascular remodeling, but key cell type–specific regulatory programs driving this process remain poorly defined. We performed single-nucle...
Abstract 4371631: Adverse events profile of Transthyretin stabilizers in Transthyretin Amyloid Cardiomyopathy - A Meta-Analysis of randomised control trials
Background: Transthyretin Amyloid Cardiomyopathy (ATTR-CM) is a progressive infiltrative cardiomyopathy with significant morbidity and mortality. Transthyretin (TTR) stabilizers su...
Abstract 4370239: Low Life’s Essential 8 Scores are Associated with Increased Risk of Revascularization After Coronary Artery Bypass and Percutaneous Coronary Intervention
Background: The American Heart Association’s Life Essential 8 (LE8) framework quantifies cardiovascular health (CVH) across key modifiable factors. Patients with prior history of p...
Abstract 4366464: Prognostic value of D-dimer and its incremental value in risk stratification models for atrial fibrillation patients with acute coronary syndrome or percutaneous coronary intervention
Background: Despite optimal medical therapy, patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) still experience higher risk of thro...
Abstract 4362359: Sex-Based Disparities In Mechanical Circulatory Support Usage Among Postmenopausal Patients With Cardiogenic Shock
Background: Cardiogenic shock often leads to hemodynamic compromise requiring immediate intervention, typically involving mechanical circulatory support (MCS). While treatment meth...
Abstract 4368601: Surviving sudden cardiac arrest during pregnancy: strategic planning for maternal and fetal outcomes
Introduction: Cardiac arrest during pregnancy is rare but presents a critical challenge requiring rapid stabilization and multidisciplinary coordination. Advanced maternal age incr...
Abstract 4368374: Turning Tides: Demographic Reversals in U.S. Infective Endocarditis Mortality (1999–2020)
Introduction: Infective endocarditis (IE) is a life-threatening condition with evolving epidemiology in recent decades. While IE-related mortality declined in early decades, recent...
Abstract 4371455: Increased Utilization of Home-Based Cardiac Rehabilitation Programs among Veterans with Ischemic Heart Disease
Objectives: Cardiac rehabilitation (CR) is a guideline recommended secondary prevention program that has been vastly underutilized despite evidence of reducing morbidity and mortal...
Abstract 4368728: Cardiovascular Risk from the 9p21 Loci is Driven by Differential Expression of GAS6-TAM Receptor in Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells
Background: The genetic underpinning of coronary artery disease is well established, with 9p21 risk loci among the strongest associated with CAD. However, the mechanistic underpinn...
Abstract 4366617: Long-Term Efficacy and Safety of a Novel Low-Dose Triple Single-Pill Combination for the Treatment of Hypertension
Background: A new low-dose triple single-pill combination (SPC) of antihypertensive drugs (GMRx2, in three strengths: ¼, ½, and standard, containing telmisartan/amlodipine/indapami...
Abstract 4364910: Trends and Stroke Outcomes in Left Atrial Appendage Clearance Using Cardiac CT Angiography Prior to Cardioversion
Introduction: Transesophageal echocardiography (TEE) has long been the standard imaging modality for left atrial appendage (LAA) thrombus exclusion before direct current cardiovers...
Abstract 4363416: Integrated Risk Modeling of Donor and Recipient Predictors of One-Year Graft Loss in Pediatric Heart Transplantation
Background: Pediatric heart transplant outcomes have improved in recent decades due to advancements in donor and recipient selection. Despite this, early graft loss—defined as graf...