Circulation
Articles in this Issue
Abstract 4364288: Increasing Rates of Lipoprotein(a) Testing in the United States from 2015-2024: An Analysis of 300 Million Individuals
Background: Lipoprotein(a) [Lp(a)] is a genetically determined biomarker associated with increased risk of cardiovascular disease. Elevated Lp(a) is common, with approximately 1 in...
Abstract 4368896: The link between distinct serum response factor isoforms and cardiovascular disease: diagnostic and therapeutic potential?
Background: Serum Response Factor (SRF) is an important transcription factor for cardiac muscle gene regulation. Alternative splicing of SRF may modulate different cardiac disease....
Abstract 4370801: Dynamic Autonomic Adaptation During Cognitive Load: Heart Rate Variability Changes from Resting State to Visuo-Spatial Working Memory Task
Background: The autonomic nervous system dynamically adjusts cardiac regulation during cognitive challenges, reflecting the interplay between sympathetic and parasympathetic branch...
Abstract 4365169: Detection and Prognostic Stratification of Left Ventricular Systolic Dysfunction in Left Bundle Branch Block Using an Artificial Intelligence-enabled ECG
Background: Left bundle branch block (LBBB) significantly increases the risk of left ventricular systolic dysfunction (LVSD) due to cardiac dyssynchrony. While recent advances in a...
Abstract 4367866: Prescription Stimulants Can Increase Risk of Arrhythmias: Systematic Review and Meta-Analysis
Background: Centrally acting stimulants are widely prescribed for attention-deficit/hyperactivity disorder (ADHD), narcolepsy, and related neuropsychiatric conditions, but concerns...
Abstract 4366863: Flood and Pollution Susceptibility are Associated With Increased Rates of Sudden Death Within a Rural North Carolina County
Background: Environmental contributors to sudden death are not well understood but should inform emergency preparedness and mitigation strategies. We examined flood and pollution r...
Abstract 4368851: A Rare Case of Testicular Diffuse Large B-Cell Lymphoma with Cardiac Involvement
Description of Case: A 78-year-old male with past medical history of atrial fibrillation, hypertension, and recent admission for post-viral pericardial effusion status-post pericar...
Abstract 4370326: Modifying Mast Cell Response to Control Inflammation and Optimize Repair in Reperfused Myocardial Infarction
Background: While prolonged pro-inflammatory/delayed anti-inflammatory macrophage (MΦ) polarization post-MI promotes adverse cardiac remodeling, the impact of mast cell (MC) polari...
Abstract 4370759: Bariatric Surgery vs. GLP/GIP Agonists: A Real-World Comparative Analysis of Cardiovascular Outcomes in Over 2 Million Patients.
This retrospective cohort study utilized the TriNetX Research Network, comprising real-time electronic medical records from over 100 healthcare organizations. Adults (≥18 years) treated between 2021 a...
Abstract 4368602: Indexed baseline ascending aortic size shows non-linear relationship with future growth rate.
Background: Predicting ascending aortic growth remains challenging, with few robust clinical predictors beyond known genetic aortopathies. Most current models assume linear growth...
Abstract 4371143: Epidemiological Trends and Projections of Heart Failure Due to Cirrhosis Across 204 Countries, 1990–2050
Heart failure (HF) is a growing global health concern, and cirrhosis is an increasingly recognized non-cardiac contributor through mechanisms like volume overload, systemic inflammation, and cirrhotic...
Abstract 4370183: Sex Differences in Bystander Interventions and Outcomes among Out-of-Hospital Cardiac Arrest Patients in Middle- versus High-Income Countries in Asia and the Middle East
Introduction: Although previous research in high-income countries suggested that women are less likely to receive bystander CPR (BCPR) and tend to experience worse outcomes, there...
Abstract 4371511: High Sensitivity and Specificity of Electrocardiogram-Based AI Models for Diagnosing Peripartum Cardiomyopathy: A Systematic Review and Meta-Analys
Introduction: Artificial intelligence electrocardiograms are considered efficient for estimating ejection fraction in heart failure patients. However, whether this method is a pote...
Abstract 4355964: Probiotic Extracellular Vesicles Stimulate Macrophage Efferocytosis to Limit Ischemia/Reperfusion-Induced Damage by Delivering 5s-rRNA-Derived Short RNA
Background: Myocardial ischemia/reperfusion (I/R) injury is mainly ascribed to excessive sterile inflammation resulting from the inefficient clearance of dead cardiomyocytes by mac...
Abstract 4363590: Coronary Vasculitis in Takayasu’s Arteritis
Introduction: Takayasu’s arteritis (TAK) is a rare vasculitis that primarily affects the large arteries. Chronic inflammation within the vessel wall can lead to vascular remodeling...
Abstract 4363980: Time of day of anthracycline administration and sleep disorders increase the risk for cardiotoxicity
Introduction: The heart responds differently to injury at different times of day. This has been shown in clinical and animal studies of myocardial ischemia reperfusion injury and i...
Abstract 4357124: Echocardiographic Stratification of NT-proBNP Response to Sacubitril/Valsartan in Patients with Acute Heart Failure: A Sub-analysis of the PREMIER Trial
Background: Sacubitril/valsartan (Sac/Val) has been shown to reduce N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with acute heart failure (AHF), yet the...
Abstract 4365811: Rising Mortality from Atrial Fibrillation in Diabetic Patients in the U.S., 1999–2023: A Neglected Epidemic in Cardiometabolic Health.
Introduction: Atrial fibrillation (AF) has emerged as a critical and escalating public health threat, particularly among individuals with diabetes mellitus, a population already bu...
Abstract 4372183: Cross-species single-cell reconstruction of atherosclerosis reveals predictive monocytes for acute coronary events
Background: Vulnerable plaques are the immediate cause of acute coronary syndromes such as acute myocardial infarction (AMI). However, current preventive strategies including lipid...
Abstract 4369595: Long-Term Outcomes of Mechanical Versus Bioprosthetic Surgical Aortic Valve Replacement in Adults ≤55 Years: A Multicenter Analysis
Background: Surgical aortic valve replacement (SAVR) in younger patients (<55 years) poses a clinical dilemma between mechanical and bioprosthetic valves. Long-term outcome comp...
Abstract 4352126: Accelerated Coronary Atherosclerosis Following Relugolix Versus Leuprolide Androgen Deprivation Therapy in Men with Prostate Cancer (REVELUTION): An Open-Label Randomized Controlled Trial
Purpose: Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with cardiovascular (CV) morbidity, yet the biological basis remains unclear. Recent studies hav...
Abstract 4366870: Racial and Ethnic Differences in First-Trimester Prenatal Care Initiation Among Pregnant People with Pre-Pregnancy Hypertension
Introduction: Pre-pregnancy hypertension (HTN) is significant cause of adverse maternal and neonatal outcomes, particularly among historically minoritized groups in the US. Early p...
Abstract 4366206: ECG-IQ: Deep Learning-Enabled System that Defines Appropriateness of ECG Image Quality Enhances the Application of AI-ECG Diagnostics at the Point of Care
Background: AI algorithms for ECG images (AI-ECG) offer scalable screening and diagnosis of cardiac conditions by using images directly. However, the accuracy of predictions is hig...
Abstract 4368062: Subendocardium-involved Late Gadolinium Enhancement Pattern with Noncoronary Distribution Predicts Sudden Cardiac Death in Nonischemic Dilated Cardiomyopathy
Background: Beyond the predominant nonischemic late gadolinium enhancement (LGE) pattern, an subendocardium-involved LGE patternwas also identified in a subset of patients with non...
Abstract 4371203: Hospital Characteristics Predict Outcomes in Anterior STEMI with LBBB:A 5 Year National Inpatient Sample Analysis
Introduction: Anterior ST-segment elevation myocardial infarction (STEMI) with left bundle branch block (LBBB) represents a high-risk clinical scenario requiring urgent revasculari...