Circulation
Articles in this Issue
Abstract 4364307: VS-041, a narrow-spectrum, matrix metalloproteinase (MMP) inhibitor and novel drug candidate for heart failure with preserved ejection fraction (HFpEF), demonstrates target engagement and is safe and well-tolerated in healthy participants.
Introduction: VS-041 is a novel drug candidate for HFpEF that inhibits key MMPs implicated in cardiac fibroinflammation, and diastolic dysfunction. VS-041 also inhibits formation o...
Abstract 4367985: Association Between Physical Activity Intensity and Chronic Kidney Disease Risk in Hypertension Population: An Accelerometer-Based Study
Background: Hypertension is closely linked to kidney disease development. However, research on how to prevent chronic kidney disease (CKD) in individuals with hypertension remains...
Abstract 4365268: Gender Based Disparities in the Utilization and Outcomes of Mechanical Circulatory Support Devices Use Among Patients with Myocardial Infarction: Insights From a Nationwide Data Analysis
Background: Studies have revealed Gender-based differences in the management and outcomes of myocardial infarction (MI), with women often facing a poorer prognosis compared to men....
Abstract 4358082: Population Screening for LV Dysfunction Using Single-Lead ECG-AI: Insights from the RURAL Study
Background: Moderate to severe left ventricular dysfunction (LVD), defined by a left ventricular ejection fraction (LVEF) <40%, is a key marker of heart failure with reduced eje...
Abstract 4359483: Clinical Effects of Acoramidis Versus Placebo in the ATTRibute-CM Study: Observations from the Intention-to-Treat Population
Introduction/Background: Acoramidis is a transthyretin (TTR) stabilizer providing near-complete (≥90%) TTR stabilization in vitro and is indicated for the treatment of wild type an...
Abstract 4357776: Prediction of major adverse clinical events using fatty liver index in patients following percutaneous coronary intervention
Introduction: Fatty liver is recognized as a risk factor for cardiovascular disease, and its severity can be assessed using the fatty liver index (FLI), a non-invasive marker calcu...
Abstract 4362692: Diagnosis of obstructive coronary artery disease with a facial foundation model
Background: Coronary artery disease (CAD) is a leading cause of mortality worldwide. Early detection remains a challenge due to the costs and limitations of traditional diagnostic...
Abstract 4341605: The U-CLEAR Study: Uncovering Hemodynamic and Vascular Contributors to Chronic Refractory Lower Extremity Edema
Background: Chronic refractory edema in the lower extremities is a disabling condition characterized by persistent swelling and venous stasis skin changes, despite standard conserv...
Abstract 4355626: Endothelial CD39 Deficiency Alters Purinergic Signaling and Increases Susceptibility to Ischemia-Reperfusion Injury
Introduction: Endothelial cells (ECs) regulate vascular tone and thrombosis through purinergic signaling, with CD39 (ENTPD1) hydrolyzing extracellular nucleotides. While elevated C...
Abstract 4367607: Disparities in Atrial Fibrillation Clinical Outcomes: Race, Ethnicity, and Sex Differences in Risk of Incident Heart Failure, Stroke, and Mortality
Introduction: Atrial fibrillation (AF) is associated with significant comorbidities, including stroke and tachyarrhythmia-associated heart failure (HF). The role of patient charact...
Abstract 4369596: The predictive value of Atherogenic index of plasma and plaque characteristics after percutaneous coronary intervention in ST-elevated myocardial infarction patients: an intravascular optical coherence tomography study
Background and Aim: This prospective study investigated plaque morphologies based on the underlying culprit lesion pathology in relation to the Atherogenic Index of Plasma (AIP) in...
Abstract 4367634: Genetic Variants and Prognosis in Hypertrophic Cardiomyopathy: A Systematic Review and Meta-analysis
Background: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease, frequently associated with sarcomere gene variants. While genetic testing is key for dia...
Abstract Sat904: A Recalled Experience of Death Among Cardiac Arrest Survivors Is Associated with Improved Psychological Outcomes
Background: Cardiac Arrest (CA) studies report negative psychological outcomes (anxiety (13-61%), depression (14-45%), post-traumatic stress disorder (PTSD) (19-27%)) among survivo...
Abstract 4346607: Incidental finding of a persistent left superior vena cava during pacemaker placement: a case report
Background: The incidence of persistent left superior vena cava (PLSVC) in the general population is estimated to be between 0.3% and 0.5%, which equates to approximately 1 in ever...
Abstract 4361427: Serial changes in post-heart transplant ejection fraction predict recipient mortality
Background: Heart transplantation (HTx) is the gold standard therapy for refractory class IV NYHA heart failure. While it has been widely observed that donor ejection fraction (EF)...
Abstract 4369783: Clinical Safety Outcomes of ICI Rechallenge following ICI-myocarditis and other Cardiotoxicities
Background: Cardiotoxicity is a major limitation to the effective use of immune checkpoint inhibitor (ICI) therapies. In non-cardiac models, rechallenge with ICI-therapy after non-...
Abstract 4369139: Characteristics and outcomes of fetuses with intrauterine ductus arteriosus constriction.
Introduction: Fetal ductus arteriosus constriction (DAC) can cause hydrops, pulmonary arterial (PA) hypertension and even death. Maternal drug/dietary factors can cause DAC and res...
Abstract 4367970: Dissecting Cellular Spatial Relationships in Severe Pulmonary Hypertension Using High-Resolution Spatial Transcriptomics
Background: Dysregulated fibroblasts and macrophages have been implicated in vascular remodeling in pulmonary arterial hypertension (PAH). Macrophages are known to modulate fibrobl...
Abstract 4365136: Using High-throughput Proteome-wide Analysis to Discover Clinical Biomarkers of Pediatric Pulmonary Arterial Hypertension
Background: Multiple studies of preclinical models and adults with pulmonary arterial hypertension (PAH) have shown new insights into PAH pathophysiology using high-throughput prot...
Abstract 4354542: Pre-ablation Weight Loss Through Bariatric Surgery Reduces In-hospital Complications After Catheter Ablation in Patients With Atrial Fibrillation/Atrial Flutter
Background: Obesity is associated with increased in-hospital complications in patients with atrial fibrillation and atrial flutter (AF/AFL). The effects of weight loss intervention...
Abstract 4372476: Recent Rise in Ischemic Stroke Mortality with Comorbid Type 2 Diabetes and Associated Demographic Disparities: A Nationwide Study (1999–2020)
Background: Type 2 diabetes (T2D) is a well-established risk factor for ischemic stroke (IS), yet national trends in IS mortality with T2D as a contributing cause remain poorly cha...
Abstract 4366435: Disparity in Stroke-Related Hospitalizations in the United States (2008–2020): A Nationwide Analysis by Demographics and Region
Background: Stroke is one of the leading causes of long-term disability and mortality in the United States. While clinical care has improved, the demographic and regional shifts in...
Abstract 4371591: Automated End-to-End Framework for Extracting Raw ECG Waveforms and ST Segment Values from ECG Reports and Predicting ST Elevation by Machine Learning
Background: Manual analysis of ECG reports can be time-consuming and difficult to perform. Machine learning (ML) models have shown higher success when trained on raw time-series ra...
Abstract 4368969: Cardiovascular and Rhythm Benefits of GLP-1 Receptor Agonists in Obese Patients: A Real-World Multicenter Study
Background: Obesity is a well-established risk factor for cardiovascular diseases, including atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF). Gl...
Abstract 4373497: Evaluating the Therapeutic Potential of Cord-Derived Stem Cells in Hypoplastic Left Heart Syndrome: A Comparative Analysis
Background: Hypoplastic Left Heart Syndrome (HLHS) is a severe congenital heart defect, representing approximately 2–4% of all congenital heart diseases and accounting for 23% of n...