Circulation
Articles in this Issue
Abstract 4372915: In a vascular disease cohort, pTau217 correlates with processing speed and executive function, but not memory.
Introduction: Cerebrovascular disease and vascular risk factors have important contributions to Alzheimer’s disease (AD) risk, and greater understanding of cognitive changes in vas...
Abstract 4367774: Outcomes of HIV-Positive Patients with Cardiac Implantable Electronic Device–Related Infective Endocarditis (CIED-IE): A Prospensity Score-Matched Analysis of National Inpatient Sample Data(2016-2022)
Introduction: Cardiac Implantable Electronic Device-related Infective Endocarditis (CIED-IE) is a common cause of hospitalization, and is associated with significant morbidity and...
Abstract 4367733: Dual Therapy With Glucagon-like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors Is Associated With Improved Outcomes in Patients With Heart Failure: A Real-World Propensity-Matched Cohort Study
Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are guideline-directed therapies for heart failure (HF), independent of left ventricular ejection fraction. Glucagon-...
Abstract 4371293: Missed Opportunities for Cardiovascular Prevention in the United States: A Simulation-Based Analysis Using NHANES 2021–2022
Background: Despite clear guidelines, many high-risk individuals in the U.S. remain untreated for ASCVD prevention. We quantified the prevalence of missed treatment opportunities,...
Abstract 4366821: Stress Cardiomyopathy Without Acute Stress: Potential Delayed Impact of a Neurological Insult
Background: Takotsubo syndrome (TTS) is a reversible cardiac condition typically triggered by acute stress, causing transient left ventricular dysfunction. Neurological insults lik...
Abstract 4370578: Dual-Chamber Leadless Pacemaker Implantation in an Orthotopic Heart and Kidney Transplant Recipient With ESRD and Transient Atrial Non-Capture
Background: Leadless pacemakers offer advantages in immunosuppressed patients or those with limited venous access. This case highlights the novel use of a dual-chamber leadless pac...
Abstract 4371603: Cerebral Embolic Protection in TAVI: Does It Improve Outcomes? A Comprehensive Meta-Analysis and Trial Sequential Analysis
Background: Previous evidence from randomized controlled trials (RCTs) on cerebral embolic protection (CEP) during transcatheter aortic valve implantation (TAVI) has been inconclus...
Abstract 4369713: Peripheral Artery Disease Outcomes in GLP-1RA Trials: Meta-Regression of SBP, HbA1c, and Weight.
Introduction/Background: Peripheral artery disease (PAD) affects over 113 million people globally and is a major cause of limb loss, particularly diabetic patients. GLP-1 receptor...
Abstract 4357624: Postpartum Bradycardia-Induced Ventricular Tachycardia in Congenitally Corrected Transposition of Great Arteries with Complete Heart Block: A Rare and Life-Threatening Complication
INTRODUCTION: Congenitally corrected transposition of the great arteries(CCTGA) is a rare congenital heart defect characterized by L-looping of the heart tube,resulting in atrioven...
Abstract 4336478: Trends and disparities in hospice care utilization in patients with heart failure in the United States from 2003 to 2020: Analysis of CDC WONDER database
Background: Heart failure (HF) is a life-threatening condition and a major global cause of mortality, with 56.19 million cases reported worldwide by 2019. In the US, HF contributes...
Abstract 4362907: Inhibition of Fibrin Formation by the GPRP–Dextran Conjugate: A New Approach to Safe Anticoagulation
Introduction: Fibrin formation begins with the thrombin-catalyzed cleavage of fibrinopeptide A from fibrinogen followed by exposure of the Gly-Pro-Arg(GPR) sequence called knob 'A'...
Abstract 4369129: Essential Role of KCNQ5 (Kv7.5) Potassium Channels in Vascular Reactivity and Adrenergic Signaling
Introduction/Background: Vascular tone dysregulation is central to cardiovascular pathophysiology. KCNQ (Kv7) potassium channels, primarily heteromeric KCNQ4/5 channels, regulate s...
Abstract 4359904: Trends in Hypertension-Related Mortality Among U.S. Adults Aged 15–44: A Pre-, Peak-, and Post-COVID-19 Analysis
Background: Hypertension (HTN) is a key modifiable risk factor for cardiovascular morbidity and mortality. Though often linked to older adults, HTN-related deaths are rising among...
Abstract 4369575: Metformin Modulates Vascular Function in Fetal Placental Vessels with Gestational Diabetes Mellitus
Background: Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy and a major risk factor for endothelial dysfunction, hypertension, and future car...
Abstract 4366365: Prognostic Significance of Mitral Annular Calcification Assessed by Computed Tomography for Transcatheter Edge-to-Edge Repair Outcomes
Background: Mitral annular calcification (MAC) presents significant challenges for the transcatheter edge-to-edge repair (TEER) procedure. However, there are limited data on how th...
Abstract 4363474: Retrospective Analysis of the Impact of Ischemic Time and Race/Ethnicity on Survival and Mortality after Heart Transplantation
Background: Cold ischemic time influences post-transplant outcomes in heart transplantation. Despite medical advances, racial disparities persist in cardiac transplantation mortali...
Abstract 4369322: Sex-Based Differences in Systolic Blood Pressure Response After Renal Denervation: A Meta-Analysis
Introduction/Background: Renal denervation (RDN) is an emerging interventional endovascular procedure for the management of resistant hypertension. While its efficacy is well estab...
Abstract 4366193: Overexpression of Connexin-43 Improves Electrical Conduction between hiPSC-derived Cardiomyocytes
Introduction: Therapy implanting cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) is a promising technique to treat damaged myocardium. However, elec...
Abstract 4363348: Multi-View Deep Learning for Automated Quantification of Aortic Stenosis
Background: Accurate assessment of aortic stenosis (AS) severity is critical to reduce associated morbidity and mortality. Current evaluation relies on expert interpretation of B-m...
Abstract 4360579: The Effects of Autoimmune Rheumatic Diseases on the Development of Clonal Hematopoiesis
Background: Observational studies have proposed that genetic susceptibility to autoimmune rheumatic disease predisposes to the development of clonal hematopoiesis of indeterminate...
Abstract Sun1004: A Synthetic Small Molecule Efficiently Sequesters Carbon Monoxide from Hemoglobin and Red Blood Cells <i>In Vitro</i>
Introduction: Carbon monoxide (CO) poisoning is the most common human poisoning and a major cause of death and disability with over 50,000 cases annually in the U.S. Currently, no...
Abstract 4369697: Prothrombin Complex Concentrate versus Fresh Frozen Plasma for hemostatic management in patients undergoing cardiac surgery: A Meta Analysis of Randomised Controlled Trials
Background: Fresh frozen plasma (FFP) is conventionally used for the management of bleeding and reversal of coagulopathy in cardiac surgery. It carries the risk of complications li...
Abstract 4370142: Machine Learning–Driven Optimization of EEG Channel Selection for Cognitive State Monitoring
Background: Wearable electroencephalography (EEG) devices enable noninvasive, real-time monitoring of cognitive states such as attention and stress. However, their practical deploy...
Abstract 4363040: Re-Evaluating the Unassuming Assumption: Lessons from Hemodynamic Predictors in Heart Transplant Outcomes
Background: Cox proportional hazards models are common statistical methods widely used in cardiovascular research that depend on several key assumptions of the data to ensure valid...
Abstract 4346945: Pharmacogenomic Profiling Improves Blood Pressure Control in Resistant Hypertension: A Precision Medicine Approach
Background: Resistant hypertension affects approximately 10-20% of hypertensive patients. Emerging evidence suggests genetic variation significantly influences antihypertensive dru...