Circulation
Articles in this Issue
Abstract 4365881: Predictive value of plasma biomarkers for two-year risk of developing carotid plaque in healthy population
Background and Aims: Carotid plaque is an early manifestation of atherosclerosis and is closely associated with the risk of myocardial ischemia, ischemic stroke, and other atherosc...
Abstract 4356907: Comparative Diagnostic Accuracy of CT-Derived Fractional Flow Reserve and Dobutamine Stress Echocardiography in Stable Coronary Artery Disease: A Systematic Review
Background: Accurate non-invasive functional testing is essential for managing stable coronary artery disease (CAD). While Dobutamine Stress Echocardiography (DSE) is widely used,...
Abstract 4366363: Accessibility of Vascular Surgeons in Communities at High Risk for Peripheral Artery Disease
Background: Peripheral artery disease (PAD) is highly prevalent, but many patients face access challenges related to the number and distribution of vascular specialists. We hypothe...
Abstract 4366892: Air Pollution, Social Vulnerability, and Cardiovascular Outcomes in Individuals With Coronary Artery Disease
Background: Ambient air pollutants such as fine particulate matter (PM 2.5 ), nitrogen oxides (NO x...
Abstract 4363160: Clinical Outcomes with Optical Coherence Tomography vs Angiography or Intravascular Ultrasound Guided Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Background: Angiography has been the standard for imaging guidance during the Percutaneous Coronary Intervention (PCI) in patients with Myocardial Infarction. Intravascular ultraso...
Abstract 4361419: Isoproterenol-Enhanced Transesophageal Echocardiography to Differentiate Left Atrial Appendage Thrombus from Dense Spontaneous Echo Contrast: A Meta-Analysis
Background: Distinguishing dense spontaneous echo contrast (SEC) from true thrombus in the left atrial appendage (LAA) remains a major diagnostic challenge in atrial fibrillation (...
Abstract 4366765: Intervention to Improve Medication Adherence and Symptom Perception in Patients with Heart Failure
Background: Self-care is key to optimal outcomes in patients with heart failure (HF) which includes adhering to prescribed medications and regular symptom monitoring. While medical...
Abstract 4370198: Inverse Salt Sensitivity Is Associated With The Presence Of The Human Dopamine D2 Receptor rs6277 Single Nucleotide Polymorphism.
Inverse salt sensitivity, an increase in blood pressure (BP) when sodium intake is reduced, affects about 10-15% of the population, yet the mechanisms underlying this alteration in BP are not well und...
Abstract 4359468: Disparities in Cardiac Resynchronization Therapy Utilization Among Women with Heart Failure with Reduced Ejection Fraction and Left Bundle Branch Block: The Impact of Breast Cancer Status
Background: Cardiac resynchronization therapy (CRT) has been demonstrated to reduce both mortality and morbidity in patients with LBBB. Despite this, CRT remains underutilized in c...
Abstract 4369515: Sex Differences in the Association of Obesity and Adiposity with Eicosanoid Metabolites
Introduction: Sex differences in obesity-related cardiovascular disease (CVD) are widely recognized, but the underlying inflammatory pathways driving these differences remain poorl...
Abstract 4366509: Total Carotid Artery Calcium Score on Standard-of-care Oncologic Computed Tomography Scans Predicts Radiation-induced Carotid Artery Disease and its Sequelae in Patients with Oropharyngeal Cancer
Introduction: Radiation therapy (RT) induced carotid artery disease (RICAD) is a significant contributor to morbidity and mortality of oropharyngeal cancer (OPC) survivors. Pre-exi...
Abstract 4370607: Clinical Outcomes of Fractional Flow Reserve vs. Intravascular Imaging–Guided Percutaneous Coronary Intervention in Intermediate Coronary Lesions: An Updated Meta-Analysis of 5,445 Patients
Background: Managing intermediate coronary lesions (ICL) remains a clinical challenge, as angiography alone may be insufficient to guide optimal revascularization. Both Fractional...
Abstract 4370507: Increased Mortality and Complication Rates in Weekend Admissions for Acute Decompensated Heart Failure
Background: The "weekend effect," marked by higher mortality and complications for weekend hospital admissions, is established for myocardial infarction and stroke but understudied...
Abstract 4339402: Cholesterol-Driven Monocyte mTORC1 Activation and Autophagy Suppression in Hypercholesterolemic Patients: A Translational Link to Atherosclerosis
Background: While statin therapy effectively lowers plasma LDL cholesterol (LDL-C), residual cardiovascular risk remains. Emerging evidence suggests that LDL-C may exert deleteriou...
Abstract 4362812: Metabolic interventions modulate arrhythmogenic cardiomyopathy phenotype and severity in knock-in mice carrying Tmem43 S358L mutation.
Background: The TMEM43 S358L mutation causal for arrhythmogenic cardiomyopathy (ACM), a sex-influenced disease, affects cardiac, small intes...
Abstract 4358302: A Case of Immune Checkpoint Inhibitor-Induced Myocarditis with Myositis and/or Myasthenia Gravis Overlap Syndrome with New Right Bundle Branch Block and Negative Cardiac MRI
Case Description: The patient is an 85-year-old male with hypertension, paroxysmal atrial fibrillation, and stage IV prostate cancer on pembrolizumab (last dose 10 days ago) presen...
Abstract 4365870: Projected Widening of Racial and Geographic Disparities in Heart Failure Mortality Among US Older Adults by 2040
Introduction: Heart failure (HF) is a leading cause of death, hospitalization, and disability among older adults (≥75 years), a population experiencing rapid growth and disproporti...
Abstract 4365417: Timely diagnosed Giant Cell Myocarditis is not definitely lethal - A Rare Success Treatment
Giant cell myocarditis is a rare, rapidly progressive, potentially lethal disease caused by a T-cell-mediated inflammation of the myocardium. Rapid, early diagnosis is complicated by the diverse clini...
Abstract Sat901: A Patient and Family Advisory Council After Cardiac Arrest: A Patient-Centered Model of Community Engagement
Introduction: Community engagement seeks to make research and clinical interventions relevant to the lives of the community. Care after out-of-hospital cardiac arrest (OHCA) is com...
Abstract 4367586: Safety Profile of the CardioMEMS HF System in Pulmonary Arterial Hypertension: A Pooled Adverse Event Analysis from Three Clinical Studies
Introduction: Pulmonary arterial hypertension (PAH) is a progressive disease. Continuous hemodynamic monitoring may help manage more severe PAH. The CardioMEMS HF System, an implan...
Abstract 4369025: Impact of New Heart Transplant Centers on Regional Transplant Volume and Outcomes
Introduction: Heart transplantation (HT) is a critical therapy for patients with end stage heart failure. HT volumes have increased since 2010, but the demand for this therapy cont...
Abstract 4368115: Myeloid Cell R-spondin 2 Suppresses Atherosclerosis Development
Background: Monocyte-derived macrophages play key roles in both the initiation and progression of atherosclerosis, an underlying cause of the majority of cardiovascular diseases. P...
Abstract 4369172: Comprehensive Geriatric Assessment Reduces Cardiovascular Mortality and Heart Failure Hospitalizations in Older Adults: A Systematic Review and Meta-analysis
Background: Cardiovascular disease management in older adults is complicated by geriatric syndromes. Comprehensive Geriatric Assessment (CGA)—a multidisciplinary evaluation of func...
Abstract 4358798: Renal artery relaxation and its modulation by perivascular adipose tissue in relation to kidney function
Metabolic syndrome (MetS) is a cluster of conditions that increases the risk of cardiovascular diseases and type 2 diabetes. Perivascular adipose tissue (PVAT) regulates arterial tone. We previously d...
Abstract 4360248: Association Between Left Atrial Conduction Velocity and Atrial Fibrillation Recurrence After Pulmonary Vein Isolation Alone Using Radiofrequency Catheter Ablation: A Meta-Analysis and Diagnostic Accuracy Study
Background: Atrial fibrillation recurrence (AF) after catheter ablation (CA), particularly with pulmonary vein isolation (PVI), continues to pose a significant clinical burden. Eme...