Circulation
Articles in this Issue
Abstract 4369776: Multi-Omics Landscape of Skeletal Muscle Metabolic Dysfunction in HFpEF
Background: Skeletal muscle (SKM) dysfunction is a critical determinant of exercise intolerance and frailty in heart failure with preserved ejection fraction (HFpEF). Perturbed SKM...
Abstract 4354588: Unbiased Proteome of Human Myocardium and Serum Sampled at Sudden Death for Discovery of Biomarkers for Near-term Risk of Lethal Arrhythmia
Background: While chronic pathological substrates of sudden cardiac death (SCD) are well-known, the molecular triggers that predispose individuals to fatal arrhythmias...
Abstract 4366254: Risk Modeling of Same-day Missed Echocardiogram Appointments Identifies Actionable Predictors for Targeted Outreach
Title: Risk Modeling of Same-day Missed Echocardiogram Appointments Identifies Actionable Predictors for Targeted Outreach...
Abstract 4367974: Troponin Elevation Identifies High-Risk Septic ICU Patients Without Prior Cardiac Disease
Problem Statement: The prognostic value of troponin elevation in septic ICU patients without known history of cardiac disease remains unclear, particularly after accounting for ove...
Abstract 4369198: Performance of Large Language Models in Analyzing Common Hypertension Scenarios in Clinical Practice
Background/Objective: Hypertension is the most prevalent chronic disease in primary care and a leading cause of cardiovascular morbidity and mortality. Despite existing guidelines,...
Abstract 4370214: Atrial 18F-Fludeoxyglucose Avidity is Higher in Persistent than Paroxysmal Atrial Fibrillation
Background: Atrial fibrillation (AF) is marked by underlying inflammation and metabolic changes. Atrial 18F-Fludeoxyglucose (FDG) positron emission tomography (PET) can be used to...
Abstract 4358906: Growing Syphilis Epidemic Independently Affects Cardiovascular Outcomes Outcomes in New Orleans Patients
Background: Treponema pallidum causes syphilis, a sexually transmitted infection that can lead to various cardiovascular (CV) complications. However, large scal...
Abstract 4371702: Incidence and Prevalence of Ventricular Tachycardia has Increased in Most Demographics Over the Past Decade
Introduction: Ventricular tachycardia (VT) is a potentially fatal cardiac arrhythmia that originates in the heart’s ventricles and restricts the heart's ability to pump blood effec...
Abstract 4368787: The Role of Accelerated Development of Cardiovascular Disease Risk Factors in the Association between High Noise Exposure and Cardiovascular Events
Background: Noise exposure is a risk factor for the development of cardiovascular disease risk factors (CVDRFs, i.e., diabetes, hypertension, and hyperlipidemia) and major adverse...
Abstract 4360909: Gemella morbillorum Prosthetic Aortic Valve Endocarditis Following TAVR in a Patient with Prior Lymphoma: A Rare Intersection of Structural and Immunologic Risk
Background: Infective endocarditis (IE) due to Gemella species is extremely rare and typically associated with dental disease, mucosal disruption, or valvular pathology. To our kno...
Abstract 4366459: Amping the Arrhythmia: Hospital Burden of Cardiac Dysrhythmias in Psychostimulant Users
Background: Cardiac dysrhythmias (CDs) are serious cardiovascular complications increasingly observed in association with illicit stimulant use. Methamphetamine and cocaine are kno...
Abstract 4359291: Human single-nucleus RNA sequencing identifies CD47 as a therapeutic target for doxorubicin-induced cardiomyopathy
Background: Doxorubicin cardiomyopathy (DoxCM) remains a significant clinical problem, yet its underlying mechanisms remain incompletely understood. Identifying DoxCM mechanisms ca...
Abstract 4364950: Longitudinal Analysis of High Sensitivity Troponin-T and NT-proBNP During Treatment with Anthracyclines in Breast Cancer and Lymphoma Patients
Background: Anthracyclines are highly effective, yet cancer therapy-related cardiac dysfunction (CTRCD) and heart failure are known adverse effects. Elevations in hsTnT and NT-proB...
Abstract 4357941: <i>3CPR Best Abstract Award</i> : The pathogenic role of ADAMTS13 deficiency in Chronic Thromboembolic Pulmonary Hypertension
Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a critical subtype of pulmonary hypertension (PH) that develops as a sequela of pulmonary embolism(PE). Previou...
Abstract 4361654: Network Meta-Analysis of Dose-Dependent Effects of Factor XIa Inhibitors vs Direct Oral Anticoagulants for Stroke Prevention in Atrial Fibrillation
Background: Factor XIa inhibitors represent a novel class of anticoagulants that target upstream components of the coagulation cascade, aiming to reduce thromboembolic risk. As the...
Abstract 4361477: Oral anticoagulant use in patients with atrial fibrillation post-catheter ablation: A retrospective analysis of a US commercial insurance database
Introduction: Catheter ablation is an effective strategy for the maintenance of sinus rhythm and enhancement of quality of life in patients with atrial fibrillation (AF). Oral anti...
Abstract 4341369: A newly developed model of atherosclerosis caused by the stress of metabolic syndrome in apolipoprotein E knockout mouse
Background: Atherosclerotic disease is influenced by multiple factors including hypertension, dyslipidemia, and diabetes. In clinical conditions, it is rarely due to a single patho...
Abstract Or116: Association of Ventilation Rate with Outcomes of Pediatric Cardiac Arrest
Background: The optimal ventilation rate during pediatric in-hospital cardiac arrest is not known. Research Question/Hypot...
Abstract 4366268: Longitudinal Left Atrial Volume Progression is Associated with Adverse Outcomes Independent of Septal Hypertrophy in Pediatric Hypertrophic Cardiomyopathy
Background: Baseline echocardiographic markers of diastolic dysfunction (DD), including maximum left atrial indexed volume (LAVi) and the ratio of early diastolic mitral inflow vel...
Abstract 4370603: Risk Stratification with AI-Predictive Models vs. Traditional Clinical Risk Scores in Patients Undergoing Ablation for Atrial Fibrillation: A Systematic Review and Meta-Analysis
Background: Atrial fibrillation (AF) recurrence after catheter ablation remains difficult to predict. While traditional risk scores such as CHA2DS2-VASc and HATCH are widely used,...
Abstract 4369189: Cardiac MRI Measures of T1Rho, a Novel Imaging Marker of Diffuse Fibrosis, Are Elevated in Postpartum Women with Preeclampsia
Background: Preeclampsia, a hypertensive pregnancy disorder, increases long-term cardiovascular disease (CVD) risk. While subclinical cardiac dysfunction postpartum has been report...
Abstract 4357209: Macrophage infiltration in baroreceptor neurons promotes ventricular arrhythmogenesis by inducing baroreflex dysfunction after acute myocardial infarction
Background: Ventricular arrhythmia is the leading cause of death in patients after acute myocardial infarction ( AMI ). Although the blunted...
Abstract 4367862: When to Pull the Trigger: The Critical Role of Early VA-ECMO for Neuroprotection in the Frozen Elephant Trunk Era of Acute Type A Aortic Dissection
Introduction: Acute Type A aortic dissection (ATAAD) carries a substantial risk of perioperative cerebral injury, especially during complex aortic arch reconstructions employing th...
Abstract 4370461: Aficamten is safe and effective in oHCM with comorbidities obesity, hypertension, and diabetes: a SEQUOIA-HCM sub-study
Introduction/Background: Obesity, hypertension, and diabetes commonly coexist with obstructive hypertrophic cardiomyopathy (oHCM), potentially influencing symptom burden and functi...
Abstract 4366529: Nonlinear Heavy Metal Interactions Reveal Synergistic Effects on Serum Cholesterol
Introduction: Heavy metals are harmful environmental pollutants found in air, water, soil, and food. Epidemiological and clinical studies have shown a strong association between he...