Circulation
Articles in this Issue
Abstract 4360907: Association between Water Quality and Cardiac-Specific Mortality
Background: Trihalomethanes, by-products of drinking water disinfection and quality improvement, have been heavily studied as potential carcinogens. Efforts by the Environmental Pr...
Abstract 4362971: Localized hydrogel delivery of a small molecule inhibitor of fibroblast activation protein alters the trajectory of post-myocardial infarction remodeling
Background: Increased fibroblast activation protein (FAP) has been identified to occur within the myocardial infarction (MI) region in both patient and animal studies and has been...
Abstract 4370988: Outcomes Associated with GLP1 Receptor Agonist Use in Hypertrophic Cardiomyopathy
Introduction: Recent studies have demonstrated the potential cardiac benefits of GLP1 receptor agonists (GLP1-RA). Specifically, these drugs have been shown to improve patient symp...
Abstract 4363113: A Systems Biology–Driven Strategy to ‘Defat’ Lipid-Associated Macrophages and Reverse Atherosclerosis
Introduction: Current atherosclerosis therapies like statins lower LDL cholesterol, but they do not reverse established plaques. Even with aggressive LDL-lowering, residual risk pe...
Abstract 4363442: Old Tool, New Tricks: Elevated RCRI Scores Signal Higher Risk Following TAVR
Introduction: The Revised Cardiac Risk Index (RCRI) is a validated tool used to predict the risk of adverse cardiac events in non-cardiac surgeries. It assigns one point for each o...
Abstract 4369510: Impact of Exercise Capacity and Blunted Blood Pressure Response on Clinical, Echocardiographic, and Prognostic Outcomes of Exercise Echocardiographic Stress Testing
Background: We studied the additive prognostic value of systolic blood pressure (SBP) response and exercise capacity on clinical, echocardiographic, and prognostic outcomes in symp...
Abstract 4368790: Increased use of temporary mechanical circulatory support is not associated with higher long-term mortality in heart transplantation
Introduction: Following the 2018 revision to the heart transplantation (HT) allocation policy by UNOS, the criteria for transplant candidates were changed to enhance access to HT a...
Abstract 4366201: Physical Activity, Perceived Social Support, and Health-Related Quality of Life in Saudi Patients with Acute Coronary Syndromes: A Cross-Sectional Study
Background: Physical activity (PA) has been shown to improve cardiovascular outcomes, including health-related quality of life (HRQoL), in patients with acute coronary syndromes (A...
Abstract 4371559: Intra-Arterial Vasodilators for Radial Artery Spasm and Occlusion Prevention in Trans-radial Coronary Procedures: A Network Meta-Analysis of Randomized Control Trials
Background: Radial artery access is the preferred approach for coronary procedures, however, radial artery spasm (RAS) and radial artery occlusion (RAO) remain frequent complicatio...
Abstract 4366407: Real-World Cardiorespiratory Impact of Respiratory Syncytial Virus (RSV) Vaccination in the USA: A Retrospective Propensity-Matched Analysis
Background: Data from observational studies revealed significant complications after respiratory syncytial virus (RSV) infections. Following results from randomized trials, the Foo...
Abstract 4371250: The association between GLP-1 RA initiation and cardiovascular events among patients treated with direct oral anticoagulants: A target trial emulation
Background: Direct oral anticoagulants (DOACs) are commonly prescribed for patients with atrial fibrillation or venous thromboembolism. Unlike Warfarin, the fixed-dose DOACs do not...
Abstract 4370001: Outcomes of Mitral Valve Transcatheter Edge-to-Edge Repair in Patients with Cardiogenic Shock: A Nationwide Cohort Analysis
Background: Transcatheter edge-to-edge repair (TEER) has emerged as an important therapeutic option for patients with severe mitral regurgitation (MR), even in the challenging cont...
Abstract 4359493: PRECISION TARGETING OF CORIN AND FURIN: A TRANSLATIONAL LEAP IN HEART FAILURE AND HYPERTENSION THERAPY
Background: Heart failure and hypertension remain leading causes of morbidity and mortality worldwide. Proteolytic regulation of natriuretic peptides (NPs) by corin and furin is es...
Abstract 4363851: Identification of ECG Abnormalities up to Two Years Prior to Symptomatic Manifestation of Pediatric Pulmonary Arterial Hypertension: A Japanese Nationwide School Screening Study
Background: Idiopathic/heritable pulmonary arterial hypertension (I/H-PAH), a disease with poor prognosis, often faces diagnostic delays due to nonspecific initial symptoms. In Jap...
Abstract 4364370: Enhanced Two Dimensional Warping For Fast, Accurate, and Robust Segmentation of Continuous Ambulatory ECG Recordings
Introduction: Accurate segmentation of long-term electrocardiogram (ECG) signals is essential for diagnosing arrhythmias and monitoring cardiac health. While traditional methods, s...
Abstract 4365228: HFrEF and HFpEF Model-Specific Remodeling of Subcellular PKA Signaling at the Ryanodine Receptors and SERCA2a
Introduction: The role of β-adrenergic receptor (βAR) signaling in heart failure with preserved ejection fraction (HFpEF) remains poorly understood. While β-blockers are effective...
Abstract 4369731: Menopausal Symptom Burden in Peri and Postmenopausal Women With Spontaneous Coronary Artery Dissection
Background: Spontaneous coronary artery dissection (SCAD) is an important cause of acute coronary syndrome in women. Although the role of sex-hormones in the pathogenesis of SCAD i...
Abstract 4370594: Associations Between Chronic Kidney Disease and Inflammatory Biomarkers in the Genetic Epidemiology Network of Arteriopathy Cohort
Background: Chronic kidney disease (CKD) has been linked to elevated inflammatory biomarkers, yet few studies have evaluated these associations using iothalamate-based measures of...
Abstract 4365640: Machine Learning–Based Prediction of Right Heart Failure After LVAD Implantation with Visualization of Individual Risk Factors
Introduction: Right ventricular failure (RVF) is a major adverse event following left ventricular assist device (LVAD) implantation. The complex mechanisms involved make it challen...
Abstract Sun906: Deep Learning for Defibrillator Shock Decision Analysis during Manual CPR
Introduction: Successful resuscitation of ventricular fibrillation (VF) out-of-hospital cardiac arrest (OHCA) relies on timely defibrillation and minimally-interrupted CPR. Defibri...
Abstract 4371092: A Chemogenetic Tool for In Vivo Control of Electromechanical Activity of hiPSC-Derived Cardiomyocytes
Introduction: Designer receptors exclusively activated by designer drugs (DREADDs) are a robust chemogenetic tool for the interrogation of cellular electrical activity. Particularl...
Abstract 4345595: Five-Year Outcomes of Glucagon-Like Peptide-1 Agonists in Obstructive Hypertrophic Cardiomyopathy: A Population-Based Retrospective Study
Background: Glucagon-like peptide-1 (GLP-1) agonists have been shown to improve outcomes across various cardiovascular diseases. However, data regarding the effects of GLP-1 agonis...
Abstract 4358543: Wrong Side of the Right Heart: Acute Right Ventricular Failure Presenting with Hypoxemic Respiratory Failure in the Setting of a Patent Foramen Ovale
Background: Acute hypoxemic respiratory is most often the result of common pathologies that are easily identifiable. However, in cases of refractory hypoxemia, further workup and m...
Abstract 4369323: Anatomic Physiological Scoring is a Comparable Predictor of Adult Congenital Operative Morbidity and Mortality
Background: The revised 2018 AHA/ACC guidelines for adult congenital heart disease (ACHD) introduced the anatomic physiological (AP) classification to better categorize disease sev...
Abstract 4370230: Sludgy Cors: Phlebotomy for Testosterone-Induced Polycythemia in Acute Coronary Syndrome
Description of Case: A 58-year-old male with history of primary hypogonadism on testosterone replacement therapy, coronary artery disease with prior myocardial infarction, type 2 d...