Circulation
Articles in this Issue
Abstract 4367250: Lncenc1 Modulates Lung Endothelial Barrier Integrity via CD59
Introduction: Acute lung injury results in endothelial dysfunction in systemic blood vessels, cardiac output, and an elevated risk of cardiovascular events. To date, no specific ph...
Abstract 4365126: Effects of Finerenone on Individual Components of the Kansas City Cardiomyopathy Questionnaire in Heart Failure With Mildly Reduced or Preserved Ejection Fraction
Background: Finerenone has been shown to improve overall health status, as measured by the aggregate summary scores of the 23-item Kansas City Cardiomyopathy Questionnaire (KCCQ),...
Abstract 4355069: Sotagliflozin Enhances Left Ventricular Function and Myocardial Perfusion in Chronic Myocardial Ischemia Through Metabolic and Redox Remodeling
Introduction: Ischemic heart disease (IHD) is the leading cause of mortality, disability, and human suffering globally, with an expected persistent rise in prevalence over the next...
Abstract 4373583: Exome Wide Rare Variant Analysis Identifies Novel Genes Associated with Coronary Artery Disease
Background: Cardiovascular disease is a leading cause of morbidity and mortality worldwide, and coronary artery disease is its most common subtype. While common variants have been...
Abstract 4353255: Estimating CardioMEMS Pulmonary Artery Diastolic Pressure With a Non-invasive Cardiac Hemodynamic Artificial Intelligence monitoring System (CHAIS)
Introduction: The implantable CardioMEMS Heart Failure (HF) system, which monitors pulmonary arterial pressures in an outpatient setting, has been shown to reduce HF hospitalizatio...
Abstract 4361678: Resolving Postoperative Atrial Fibrillation after Cardiac Surgery: The Effect of Sex on Resolvin D1 and D2 Serum Profiles
Background: POAF is a prevalent complication, occurring in 30-50% of patients undergoing cardiac surgery [1]. Although women are less likely to develop this complication, women wit...
Abstract 4360554: Mavacamten monotherapy in real-world patients with obstructive hypertrophic cardiomyopathy: Evidence from COLLIGO-HCM
Background: The mavaCamten ObservationaL evIdence Global cOnsortium in hypertrophic cardiomyopathy (COLLIGO-HCM, ClinicalTrials.gov ID NCT06372457) is a global observational study...
Abstract 4366648: A Fat Chance: Paradoxical Embolic Stroke from Lipomatous Hypertrophy of the Interatrial Septum
Background: Lipomatous hypertrophy of the interatrial septum (LHIS) is a rare, benign cardiac anomaly involving non-encapsulated fat infiltration of the septum, typically sparing t...
Abstract 4371406: Missed Opportunities for Stroke Prevention in Hypertensive Patients: A Retrospective Case-Control Study
Background: Hypertension, observed in 64% of patients presenting with stroke, is a well-established risk factor for stroke-related mortality, with elevated systolic blood pressure...
Abstract 4370697: NT-proBNP is a Powerful Predictor of Adverse Outcomes in Patients with Atherosclerotic Renal Artery Stenosis: A report from the CORAL trial
Introduction: N-terminal proBNP (NT-proBNP) is associated with morbidity and mortality in Heart Failure (HF), however it’s prognostic value in Atherosclerotic Renal Artery Stenosis...
Abstract 4365619: Lipoprotein(a) particle characteristics and PCSK9 determine the monocyte subtype distribution in patients with increased Lp(a) levels
Background: Monocytes, particularly the proinflammatory intermediate subsets (IM), drive atherosclerosis and predict cardiovascular events. The elevated levels of lipoprotein(a) (L...
Abstract 4336062: Histone Modifications are Associated with Altered Lipid Metabolism in the Cerebral Cortex of Neonatal Swine Following Uncomplicated Cardiopulmonary Bypass
Introduction: Excess lipolysis and dysregulated fatty acid oxidation can exacerbate neuroglial injury and impair neurodevelopment. Neurodevelopment is also regulated by histone dea...
Abstract 4354797: The Role and Mechanism of Receptor-like Protein LRTM1 in the Negative Regulation of Cardiomyocyte Regeneration
Background: One of the core pathological features of myocardial infarction is the loss of cardiomyocytes, and promoting cardiomyocyte regeneration represents a potential therapeuti...
Abstract 4370021: Cardiovascular-Kidney-Metabolic (CKM) Syndrome Development and Physical Activity Patterns Among Women of Reproductive Age: An All of US Research Program Study
Background: Despite evidence linking physical activity (PA) to improved cardiovascular outcomes, its impact on cardiovascular-kidney-metabolic syndrome (CKM) progression among wome...
Abstract 4362363: Recent Trends and Outcomes of Mechanical Complications of Acute Myocardial Infarction
Background: Mechanical complications (MC) of acute myocardial infarction (AMI) [papillary muscle rupture (PMR), ventricular septal rupture (VSR), and ventricular free wall rupture...
Abstract 4362282: Ventricular Tachycardia (VT) and Ventricular Fibrillation (VF) Related Mortality: Trends and Disparities in Heart Failure Patients (1999-2023)
Background: Sudden cardiac death from ventricular tachycardia (VT) and ventricular fibrillation (VF) remains a major cause of mortality in heart failure patients. Understanding lon...
Abstract 4368656: Association of Cardiovascular Health and Left Atrial Strain in the ARIC Study
Introduction: Left atrial (LA) strain is associated with important outcomes including atrial fibrillation, stroke, dementia, and heart failure. Several individual cardiovascular (C...
Abstract 4368630: Prevalence of FDG-avidity in genetic cardiomyopathy and prediction of arrhythmic free survival
Introduction: Cardiac 18 FDG-PET is an imaging modality frequently used to diagnose inflammatory cardiomyopathies such as cardiac sarcoidosi...
Abstract 4363309: Association of Biologic Therapy in Inflammatory Bowel Disease and Risk of Cardiac Arrhythmias: A Multicenter Cohort Study
Introduction/Background: Patients with inflammatory bowel disease (IBD) are at increased risk for cardiac arrhythmias due to chronic systemic inflammation. The potential protective...
Abstract 4370695: Effects of RAMP expression on location-biased signaling by CLR
Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a lung blood vessel disease characterized by abnormal pulmonary arterial endothelial cell (PAEC) function. Adre...
Abstract 4340646: Efficacy of Beta-Blocker Therapy in Takotsubo Cardiomyopathy: A Systematic Review and Meta-Analysis
Background: Takotsubo cardiomyopathy (TTC) is a stress-induced condition with limited evidence-based treatment options. Beta-blockers are commonly used, yet their efficacy remains...
Abstract 4367767: Implementation of Cardiac Monitoring in ARDS: A Systematic Review and Implementation Framework
Background: ARDS affects 200,000 patients annually with 35-60% mortality. Cardiac dysfunction occurs in 60-78% of patients, yet systematic monitoring exists in <30% of ICUs desp...
Abstract 4368299: Natto Red Yeast Rice Dietary Supplement Regulates Lipids Profiles: a Multicenter, Double-Placebo, Double-Blinded, Randomized Controlled Trial
Introduction: Natto Red Yeast Rice (NRYR) is a kind of dietary supplement, and its effectiveness to regulate lipid profiles, especially in combination with statins, is unknown....
Abstract 4339015: NSTEMI Secondary to Embolic Prosthetic Valve Thrombus: A Rare Post-TAVR Complication
Background: Non-ST-elevation myocardial infarction (NSTEMI) typically results from plaque rupture leading to obstructive coronary artery disease. However, embolic thrombi originati...
Abstract 4366862: Direct To Catheter Ablation and Pre-Ablation Rate Control Have Similar Outcomes in Persistent Atrial Fibrillation
Objective: To compare outcomes of direct-to-catheter ablation (DTCA) versus pre-ablation rate control using metoprolol or diltiazem in patients with persistent atrial fibrillation...