Circulation
Articles in this Issue
Abstract 4369724: Lactosylceramide Drives Pathological Cardiac Remodeling and Mitochondrial Dysfunction in a Novel <i>in vivo</i> Model of HLHS Heart Failure
Introduction: While heart failure (HF) remains the leading cause of death and indication for transplant in patients with Hypoplastic Left Heart Syndrome (HLHS), the molecular mecha...
Abstract 4363865: Unaffected Carriers of a Pathogenic <i>BMPR2</i> Variant Exhibit a Distinct Cytokine Signature Associated with Subclinical Changes on Right Ventricular and Pulmonary Vascular Imaging
Introduction: Pathogenic BMPR2 variants are a major genetic risk factor for pulmonary arterial hypertension (PAH), though the disease shows...
Abstract 4362330: Multi-Omics Biomarkers in Heart Failure: A Comprehensive Systematic Review and Meta-Analysis Towards Precision Prognostication and Therapy
Background: Heart failure (HF) is a leading cause of global morbidity and mortality, yet current clinical biomarkers offer limited prognostic precision and therapeutic guidance. Em...
Abstract 4371259: Trends in Heart Failure and Pulmonary Embolism-Related Mortality Among Older Adults in the United States from 1999 to 2020: A Nationwide CDC WONDER Analysis
Introduction: Pulmonary embolism (PE) remains a leading cause of cardiovascular mortality in the US, affecting around 900,000 people annually. Older adults with heart failure (HF)...
Abstract 4363248: GLP1 Receptor Agonist Use in Obstructive Sleep Apnea and the Risk of Developing Atrial Fibrillation
Introduction: GLP1 receptor agonists (GLP1-RA) are increasingly prescribed, with many of their potential benefits elucidated in recent studies. Consequently, GLP1-RAs were recently...
Abstract Sun501: Incidence of Malignant Arrhythmias During and After Targeted Temperature Management
Introduction: Malignant arrhythmias (MA), including ventricular tachycardia and ventricular fibrillation, represent potentially significant complications in patients undergoing the...
Abstract 4365288: Silent Storm: Aortitis and Coronary Compression Unveiled in a Healthy Woman
Background: Takayasu arteritis is a rare, granulomatous large-vessel vasculitis primarily affecting the aorta and its branches. Its non-specific presentation often delays diagnosis...
Abstract 4368112: Immunogenicity of Recaticimab Does Not Impact Its Efficacy in Patients with Dyslipidemia: A Pooled Analysis of Three Phase III and One Phase Ib/II Studies
Background: Recaticimab, a humanized monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) with a novel YTE mutation, prolongs its half-life by enhanc...
Abstract 4368536: Transcatheter vs. Surgical Treatment in Aortic Stenosis with Coronary Artery Disease: A Meta-Analysis of Time-to-Event Data on 162,305 Patients
Background: The optimal treatment for aortic stenosis (AS) with concomitant coronary artery disease (CAD) is controversial. Our meta-analysis of reconstructed time-to-event data ai...
Abstract 4369626: A PROtein Signature of PlatelEt Reactivity (PROSPER) Associated with Cardiovascular Events
Background: Platelet hyperreactivity is a predictor of increased risk for cardiovascular (CV) events; however, its measurement remains technically challenging. The assessment of re...
Abstract 4371906: Targeting Oxidative Stress Before Cardiac Surgery: A Systematic Review and Meta Analysis of 65 RCTs focusing on Cardiorenal Protection from Antioxidant Supplementation
Background: Cardiac surgery remains associated with a high incidence of cardiac and renal complications, mainly due to oxidative stress. This provides a rationale for evaluating an...
Abstract 4361629: Preservation of Acetyl-Coenzyme A Synthetase 2 Sustains Cytosolic Acetyl-CoA and Protects Against Heart Failure
Background: Emerging evidence suggests that the homeostasis of cytosolic acetyl-coenzyme A (acetyl-CoA) is critical for maintaining cardiac function, especially under pathological...
Abstract 4344364: Time-dependent association between breast cancer and risk of ischemic stroke: a nationwide cohort study
BACKGROUND: The association between breast cancer diagnosis, treatment, and the risk of incident ischemic stroke remains unclear. We aimed to investigate ischemic stroke risk among...
Abstract 4370746: Efficacy and Safety of Endovascular Therapy for Distal Medium Vessel Occlusion Stroke: A Systematic Review and Meta-Analysis of Comparative Studies
INTRODUCTION: Distal medium vessel occlusions (DMVO), which represent about 25-40% of acute ischemic stroke cases, are a major cause of morbidity and mortality worldwide. Intraveno...
Abstract Or117: Differences in Survival by Resuscitation Response in Pediatric Out-of-Hospital Cardiac Arrest: A Population-Based Study of 900 Children in Houston, Texas
Introduction: Pediatric out-of-hospital cardiac arrest (pOCHA) is fatal in >90% of cases. We previously found that OHCA incidence in non-Hispanic Black (Black) children was trip...
Abstract 4364893: Ambulatory Atrial Fibrillation Ablation is Underutilized Among Women and Racial/Ethnic Minority Groups
Background: Catheter ablation (Abl) is an effective rhythm control strategy for atrial fibrillation (AF). In recent years there has been a growing trend toward performing AF Abl as...
Abstract 4347721: Associations Between Admission C-Reactive Protein and In-Hospital Mortality Amongst Patients with Cardiogenic Shock
Background: A systemic inflammatory response is common in patients with cardiogenic shock (CS) and associated with more severe disease and increased mortality. C-reactive protein (...
Abstract 4367109: Evaluation of a Novel Artificial Intelligence Electrocardiogram Tool for Early Identification of Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension
Introduction: Pulmonary hypertension (PH) is a life-threatening, progressive disease with non-specific symptoms, often leading to delayed diagnosis. Early identification of World H...
Abstract 4367394: Platelet Transcriptomics-Enabled Identification of Acute Coronary Occlusion: A Risk Stratification Tool for Guiding Early Revascularization in NSTEMI
Background: Non-ST-segment elevation myocardial infarction (NSTEMI) results from the rupture of coronary artery plaques and is driven by platelet activation, leading to non-obstruc...
Abstract 4371279: A Rare Combination: Postpartum SCAD With Fibromuscular Dysplasia
Introduction: Spontaneous coronary artery dissection (SCAD) is a rare, underrecognized cause of acute coronary syndrome, responsible for up to 4% of ACS cases, with higher incidenc...
Abstract 4368975: Cardiorenal Protective Effects of Exercise in a Model of Diabetes and Nicotine
Introduction: Diabetes Mellitus (DM) and smoking, nicotine exposure, are prominent risk factors for cardiovascular diseases (CVD). The interaction of these factors can potentiate v...
Abstract 4348998: Glucagon-like Peptide 1 Receptor Agonists and Risk of Pulmonary Hypertension
Introduction: Cardiometabolic dysfunction is a major contributor to the development of pulmonary hypertension (PH). In this context, Glucagon-like peptide 1 receptor agonists (GLP-...
Abstract 4350384: Outcomes with Impella CP in Acute Myocardial Infarction versus Heart Failure Cardiogenic Shock: Insights from the Cardiogenic Shock Working Group
Introduction: Impella CP (Abiomed, Danvers, MA) microaxial flow pumps are commonly used in acute myocardial infarction (AMI) and heart failure (HF) cardiogenic shock (CS). Contempo...
Abstract 4363504: Impact of Limited English Proficiency on Access to Care and Quality of Care in Hispanic Americans with Cardiovascular Disease
Background: Hispanic Americans with cardiovascular disease (CVD) have historically faced limited access to healthcare. However, the influence of limited English proficiency (LEP) o...
Abstract 4367319: Longitudinal Analysis of Mild Cognitive Impairment and Dementia in Heart Failure
Introduction: Heart failure (HF) is associated with higher risk of developing cognitive impairment including mild cognitive impairment (MCI) and dementia. However, longitudinal cha...