Circulation
Articles in this Issue
Abstract 4371451: Non-Invasive Prediction Tools of Elevated Pulmonary Capillary Wedge Pressure in HFpEF: A Machine Learning Analysis
Introduction: Diagnosing heart failure with preserved ejection fraction (HFpEF) remains challenging and invasive hemodynamic assessment is not easily available. A non-invasive tool...
Abstract Sun201: Impact of Systemic Nicotinamide Mononucleotide Administration on Brain Adenosine Triphosphate and Sirtuin-3 Levels Following Cardiac Arrest in Mice
Background: Nicotinamide adenine dinucleotide (NAD+) depletion after cardiac arrest (CA) contributes to neuronal injury. Systemic administration of nicotinamide mononucleotide (NMN...
Abstract 4357687: Should Women be Screened for Abdominal Aortic Aneurysm? The Impact of Ultrasound Screening on Sex Disparities associated with Abdominal Aortic Aneurysm Repair Outcomes
Introduction: Controversy surrounding the appropriateness of abdominal aortic aneurysm (AAA) screening for women has resulted in conflicting professional guidelines. While it is kn...
Abstract 4369569: Efficiency of Artificial Intelligence-Assisted Temporal Dispersion Mapping with Pulsed Field Ablation: Integration of Volta AF-Xplorer and Affera Sphere-9 System
Introduction: Pulsed Field Ablation (PFA) using the Sphere-9 catheter with the Affera™ Mapping System (S9A) has recently been approved for the treatment of paroxysmal and persisten...
Abstract 4368095: A New Analytical Approach for Noninvasive Reconstruction of the Entire Left Ventricular Pressure Waveform in Myocardial Ischemia and Infarction
Introduction: Left ventricular pressure (LVP) waveforms offer critical insight into cardiac function after myocardial infarction. LVP is typically assessed via invasive catheteriza...
Abstract 4365992: Performance of the PREVENT ASCVD Risk Calculator Across Asian American, Native Hawaiian, and other Pacific Islander Individuals: The PANACHE Study
Introduction: Accurately predicting 10-year ASCVD risk is key to guide primary prevention, yet little is known about how the AHA PREVENT ASCVD equation performs in disaggregated As...
Abstract Sun805: Relationship between ventriculoarterial coupling and hemodynamics using active decompression and impedance threshold device during automated head-up CPR
Background: Ventriculo-arterial (VA) coupling characterizes the interaction between the cardiac function and the arterial circulation afterload and reflects cardiovascular performa...
Abstract 4368147: Evidence of Cerebral Vascular Stunning Following Ischemic Stroke Revealed by Myogenic Oscillatory Activity in Rats
Introduction: Cerebral blood flow (CBF) signals contain physiological information about the dynamics of the heart, brain, and their interaction during ischemic stroke. Traditional...
Abstract 4368248: Endothelial ILK deficiency promotes cardiac dysfunction via pro-inflammatory extracellular vesicle signaling.
Introduction: Endothelial function is crucial for maintaining vascular homeostasis. Integrin-linked kinase (ILK) has emerged as a key regulator of endothelial homeostasis, preventi...
Abstract 4343082: Conscious Sedation vs. General Anaesthesia for Catheter Ablation of Atrial Fibrillation patients: A systematic review and meta-analysis
Background: Catheter ablation has become an established treatment modality for symptomatic atrial fibrillation (AF), with its utilization steadily increasing. However, the optimal...
Abstract 4367421: Cardiogenic Shock Patients Achieving Native Heart Survival With Impella 5.5 Support Still Experience Significant Skeletal Muscle Loss
Background: Impella 5.5 is increasingly used to support patients with cardiogenic shock, some of whom recover native heart function without requiring durable mechanical support or...
Abstract Sun104: Underventilation with a Small Adult Bag (1,000 ml): Persistent Gaps Despite Real-Time Flow-Guided Training
Introduction/Background: Manual ventilation is a critical, yet variable skill in prehospital and hospital care. Concerns of over-ventilation (tidal volume, rate, etc.) during bag-v...
Abstract 4365260: Safety and Prognostic Implications of Mechanical Circulatory Support-Assisted Transcatheter Edge-to-Edge Repair: Insights from the OCEAN-Mitral Registry
Background: Transcatheter edge-to-edge repair of the mitral valve (M-TEER) has demonstrated promising outcomes for patients with mitral regurgitation (MR) who are unsuitable for su...
Abstract 4365372: Tamponade and Reversible Cardiogenic Shock Due to Cyclophosphamide Myopericarditis After Haploidentical Stem Cell Transplant
Case: A 63-year-old man with history of Stage 4 Diffuse Large B-Cell Lymphoma and treatment-induced acute myeloid leukemia with incomplete hematologic recovery was admitted for red...
Abstract 4367325: Correlation and Complementary Prognostic Value of 82Rb PET-Derived Myocardial Flow Reserve and Echocardiography-Assessed Diastolic Dysfunction
Background: Coronary microvascular dysfunction (CMD) is increasingly recognized as a key contributor to diastolic dysfunction, the key pathology in heart failure with preserved eje...
Abstract 4367959: Integrated Evaluation of Diastolic Function and Myocardial Tissue Characteristics in Non-Dilated Cardiomyopathy
Background: A subset of patients with non-dilated left ventricular cardiomyopathy (ND-LVCM) presents with restrictive-like physiology despite preserved left ventricular size. Howev...
Abstract 4363723: Immunomodulatory therapy sheds light on the treatment for vasospastic angina
Introduction: Vasospastic angina (VSA) is caused by brief spasms of the main coronary artery and its major branches, resulting in varying degrees of luminal occlusion. Although vas...
Abstract 4372450: Lack of CD8+ lymphocytes protects TAC mice from cerebral hypoperfusion and cognitive impairment, independently from their impact on cerebral vascular myogenic tone
Introduction: Arterial hypertension alters the central nervous system's structural and functional integrity, leading to the decline of cognitive functions. Experimentally, the muri...
Abstract 4363705: Plasma proteomics identifies S100A8/A9 as a novel biomarker and therapeutic target for fulminant myocarditis
Introduction: Fulminant myocarditis (FM) is a severe inflammatory myocardial disease that progresses rapidly and is often fatal. Diagnosing and predicting FM is challenging due to...
Abstract 4364960: A Case of Possible IgG4-Related Constrictive Pericarditis Masquerading as Idiopathic Pericarditis: A Rare and Elusive Diagnosis
Background: Constrictive pericarditis (CP) impairs diastolic filling, commonly manifesting as right-sided heart failure. Immunoglobulin G4-related disease (IgG4-RD) is an immune-me...
Abstract 4368186: The Weekend Effect: Worse In-Hospital Outcomes in Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention
Background: Acute myocardial infarction (AMI) is a leading cause of global morbidity and mortality, with prompt percutaneous coronary intervention (PCI) essential to improve outcom...
Abstract 4365853: Association Between Renal Artery Calcification and Renal Functional Outcomes After Revascularization According to CKD Stage in Renovascular Hypertension
Background: Calcification is a well-established prognostic marker for coronary artery disease. However, its implications for renal artery stenosis are not well understood, particul...
Abstract 4366427: Sphingosine-1-Phosphate Treatment Optimizes Cardiolipin Profile in Transplanted Right Ventricular Murine Myocardium
Background: The success of cardiac transplant is limited by ischemia reperfusion injury and resultant primary graft dysfunction which can be right, left, or biventricular. Few stud...
Abstract 4365237: Pulsed-Field Ablation Achieves Superior 12-Month Arrhythmia-Free Survival, Comparable Safety, and Shorter Procedure Times Versus Thermal Ablation in Paroxysmal Atrial Fibrillation: An Updated Systematic Review and Meta-Analysis
Introduction: Catheter ablation is a cornerstone therapy for symptomatic paroxysmal atrial fibrillation (AF), yet durable arrhythmia suppression with radiofrequency or cryo-balloon...
Abstract 4361825: Risk Stratification Model on Mortality in Vulnerable Patients with Chronic Limb-Threatening Ischemia
Background: The prevalence of peripheral arterial disease, including chronic limb-threatening ischemia (CLTI), is globally increasing due to the aging society and the pandemics of...