Circulation
Articles in this Issue
Abstract 4362243: Unseen and Unstoppable: The Burden of Hypertensive Renal Disease in the U.S. - A 22-Year Mortality Analysis (1999–2020)
Background: Hypertensive renal disease (HRD) is a major contributor to chronic kidney disease and closely linked to cardiovascular pathology. The findings aim to assess trends for...
Abstract 4369183: Artificial Intelligence in Non-Invasive Fetal ECG: A Systematic Review of Extraction and Analysis Techniques
Background: Abdominal fetal electrocardiography (fECG) is an emerging noninvasive tool for fetal monitoring. A key challenge is separating the weak fetal signal from overlapping ma...
Abstract 4362302: Premature Menopause and Polygenic Risk on Incident Coronary Artery Disease among Postmenopausal Women
Introduction: Cardiovascular disease (CVD) remains the leading cause of death among women. Premature menopause (onset <40 years) is a recognized risk-enhancing factor for corona...
Abstract 4366739: Impact of Cardiac Myosin Inhibitors on Cardiac Morphology and Function in Hypertrophic Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials
Background: Cardiac myosin inhibitors (CMIs) reduce myocardial contractility, alleviating symptoms and improving cardiac function in hypertrophic cardiomyopathy (HCM). They offer a...
Abstract Sun202: Post-resuscitation Sedation with Dexmedetomidine during Targeted Normothermia Enhances EEG Recovery and Improves Survival in Mice
Introduction: Neurological recovery after cardiac arrest (CA) remains poor. While majority of comatose post-arrest patients are sedated, its benefits under normothermia remain uncl...
Abstract 4362370: Impact of Coronovirus-19 on Physical Activity Measured by Cardiac Implanted Devices in a Veteran Population
Introduction: We investigated the impact of COVID-19 on physical activity (PA) in a veteran population with implanted cardiac devices by analyzing data from the devices’ embedded a...
Abstract 4366657: A Case of Steroid-Refractory Immune-checkpoint-inhibitor Induced Myocarditis Responsive to Mycophenolate and Anti-thymocyte globulin
Introduction: Pembrolizumab, an immune checkpoint inhibitor (ICI), is a monoclonal antibody that binds to PD-1 receptors on T-cells and prevents their inhibition by certain tumors,...
Abstract 4368640: The Platelet Reactivity ExpreSsion Score and Response to Antiplatelet Therapy
Background: Identifying platelet hyperreactivity is critical for selecting patients who may benefit from antiplatelet therapy in cardiovascular (CV) prevention. We previously devel...
Abstract 4339332: Vericiguat and Cardiovascular Outcomes in Patients with Heart Failure with Reduced Ejection Fraction
Background: Vericiguat, a soluble guanylate-cyclase stimulator, has been shown in randomized trials to reduce the composite risk of cardiovascular death or heart-failure hospitaliz...
Abstract 4370443: Apelin Signaling Protects Against Experimental Pulmonary Hypertension-Induced Right Ventricular Remodeling Through Regulation of the Renin Angiotensin Aldosterone System
Rationale: Right ventricular (RV) function is the major determinant of survival in pulmonary hypertension (PH); however, no RV-directed therapies exist. Apelin is a secreted peptid...
Abstract 4350254: Unveiling the Dual Impact of HCN4 Gene Mutation: A Case of Cardiac and Mood Disorder Manifestation
A 16-year-old-male presented in 2016 after a fall with a concussion due to dizziness. Chest X-ray showed a prominent cardiac silhouette. Further workup showed an echocardiogram with no left ventricula...
Abstract 4367289: Rhythmic feeding behavior modifies the circadian phase in the autonomic regulation of heart rate in mice
Background: Eating during the appropriate time of day can mitigate changes in autonomic cardiovascular risk factors. The goal of this study is to determine the mechanism(s) that co...
Abstract 4367732: Leadless Pacemaker Implantation in the Region of Bachmann’s Bundle: Initial Results
Background: Leadless pacemakers are an emerging technology offering a less invasive alternative to traditional transvenous systems. Bachmann bundle (BB) pacing is a novel atrial pa...
Abstract 4370582: Association Between Intrinsic Frequencies of Carotid Pressure Waveforms and AHA Cardiovascular Health Score: The Framingham Heart Study
Introduction: The American Heart Association’s (AHA) Life’s Simple 7 (LS7) score defines cardiovascular health (CVH) and promotes healthy lifestyle behaviors through seven key comp...
Abstract 4364551: Post-Ischemic Administration of Empagliflozin Reduces Cerebral Infarction but Not Edema in a Rat Ischemic Stroke Model
Background: We previously reported that empagliflozin (EMPA), a sodium-glucose co-transporter 2 inhibitor, significantly reduced infarct size and cerebral edema in a rat model of i...
Abstract 4342673: A Precision Medicine Approach to Predicting Pathogenicity and Disease Penetrance Among Variants in Hypertrophic Cardiomyopathy-Associated Genes at a Population Level
Background: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy. As genomic sequencing becomes more widespread, early identification of at-risk individual...
Abstract 4357104: Relevance Of Stellate Ganglion Blockade In Patients With Refractory Ventricular Arrhythmias- A Systematic Review
BACKGROUND: Life-threatening cardiac arrhythmias such as ventricular tachycardia (VT) and ventricular fibrillation (VF) may persist despite treatment. Given the significant morbidi...
Abstract 4370683: Multi-omics Profiling Defines the Cellular and Molecular Evolution of Progressive Right Ventricular Dysfunction
Background: Right ventricular dysfunction (RVD) is the leading cause of mortality in pulmonary arterial hypertension, but there are no available RV specific therapies. At present,...
Abstract 4364195: A transformative LDL cholesterol–lowering <i>in vivo</i> CRISPR gene editing medicine that functionally upregulates LDLR in mice and non-human primates
Background: Elevated low-density lipoprotein cholesterol (LDL-C) is a key risk factor for atherosclerotic cardiovascular disease (ASCVD), and reducing LDL-C lowers major adverse ca...
Abstract Sun604: Evaluation of Factors Impacting Community Race and Ethnicity Outcome Disparities for Out-of-Hospital Cardiac Arrest Using Mediation Analysis
Background: Out-of-hospital cardiac arrest patient (OHCA) patients from minority communities have worse outcomes, and the factors contributing to this outcome gap are unclear. We u...
Abstract 4364110: Etiology-Based Clinical and Economic Outcomes Among Hospitalizations for Cardiogenic Shock in the United States: An Analysis of the National Inpatient Sample
Introduction: Cardiogenic shock (CS) remains a high-mortality condition with variable outcomes depending on underlying etiology. Common causes include acute coronary syndrome (ACS)...
Abstract 4371348: A Multi-Center Clinic Site Comparison of Patient-level factors Affecting Oral Anticoagulation Prescription for Atrial Fibrillation
Introduction: Stroke remains a major cause of morbidity and mortality in patients with atrial fibrillation (AF). Although rates of oral anticoagulation (OAC) use have been improvin...
Abstract 4365437: Serum Transthyretin as a Screening Tool For Transthyretin Amyloid Cardiomyopathy
Introduction: Diagnosing transthyretin amyloid cardiomyopathy (ATTR-CM) remains challenging due to overlapping clinical features with causes of heart failure. Current screening too...
Abstract 4368331: Direct Oral Anticoagulants versus Dual Antiplatelet Therapy After Left Atrial Appendage Closure: A Systematic Review and Meta-analysis
Background: Left atrial appendage closure (LAAC) has recently gained prominence as a pivotal intervention for managing atrial fibrillation (AF), particularly among patients contrai...
Abstract 4363840: Clinical Characteristics of Idiopathic Cardiomyopathy After Optimal Medical Therapy in Working-Age Patients in a Regional Community Hospital
Background: Our hospital is the only acute care facility in the Nishu district (population ~64,000), enabling comprehensive capture of heart failure (HF) hospitalizations. Idiopath...