Circulation
Articles in this Issue
Abstract 4362626: Lower Very Short-Term Blood Pressure Variability Is Associated with Atrial Fibrillation Recurrence after Catheter Ablation
Background: Very short-term blood pressure variability (BPV), derived from pulse transit time monitoring, is recently recognized as an independent cardiovascular risk marker. Howev...
Abstract 4371150: Psychological Distress and Impaired Physical Function in Women Diagnosed with Coronary Microvascular Dysfunction
Introduction: Women with chest pain but no obstructive coronary artery disease (oCAD) may have coronary microvascular dysfunction (CMD), which is linked to ischemia, increased card...
Abstract 4368295: Acoramidis Reduces All-Cause Mortality and First Cardiovascular Hospitalization in Patients with Variant Transthyretin Amyloid Cardiomyopathy: Results From the ATTRibute-CM Study
Introduction: Patients with variant transthyretin (TTR) amyloid cardiomyopathy (ATTRv-CM) experience early onset disease, rapid progression, and poor outcomes due to amyloid aggreg...
Abstract 4365645: Evolving Disparities in Cardiomyopathy and Liver Disease Mortality Over Two Decades: A National Analysis by Race and Gender
Background: Cardiomyopathy and liver diseases are recognized as interrelated conditions due to their shared mechanisms, including systemic inflammation, neurohormonal dysregulation...
Abstract 4366559: Diagnostic Utility of Computed Tomography Angiography (CTA) after an Abnormal or Non-diagnostic Stress Test
Background: Coronary computed tomography angiography (CCTA) is widely recognized as a valuable non-invasive tool for evaluating patients with suspected coronary artery disease (CAD...
Abstract 4370791: The Use of Gastrointestinal Reflux and Pro-Motility Medications in Hospitalized Infants with Congenital Heart Disease using the Pediatric Acute Care Cardiology Collaborative Registry
Introduction: Infants with congenital heart disease (CHD) face challenges with feeding and nutrition. These infants have an increased rate of gastroesophageal reflux, delayed gastr...
Abstract 4368615: Trends and Disparities in Hypertension–Related Mortality in Obese Adults Aged 25 and Older From 1999 to 2023: A CDC WONDER Database Analysis
Introduction: Obesity is a cardinal national health concern firmly linked to cardiovascular disease and a primary driver of hypertension (HTN) through mechanisms such as neurohormo...
Abstract 4340081: Machine Learning-Based Prediction of Right Ventricular Failure Following Left Ventricular Assist Device Implantation
Background: Right ventricular failure (RVF) is a significant and potentially fatal complication following left ventricular assist device (LVAD) implantation. Clinically, RVF post-L...
Abstract 4370090: Association between Population Level Social Risk Factors and Prevalence of Stroke
Background: Stroke is a leading cause of death in the US and is associated with long term disability. Social risk factors such as access to health care, living in poverty, and econ...
Abstract 4363557: Brisk Usual Walking Pace Causally Remodels Brain, Heart and Metabolic Tissues
Background: Physical activity benefits multiple organs, yet its causal molecular mechanisms remain unclear. We hypothesised that a faster usual walking pace drives coordinated orga...
Abstract 4369182: Sex-Based Outcomes of Transvenous Lead Extraction at a Large-Volume US Center
Background: Transvenous lead extraction (TLE) is a well-established procedure with expanding indications in contemporary practice. However, sex-specific outcomes remain understudie...
Abstract 4364976: Coronary Microvascular Dysfunction Endotypes are Associated with Increased Pro-Inflammatory State in Angina with Non-Obstructive Coronary Arteries
Introduction: Coronary microvascular dysfunction (CMD) is the primary pathophysiological mechanism in Angina with Non-Obstructive Coronary Arteries (ANOCA), a prevalent yet underst...
Abstract 4366439: Adipose tissue extracellular vesicles mediate pro-arrhythmic changes in atrial cardiomyocytes
Background: Obesity increases the risk of arrhythmias, such as atrial fibrillation. How increased adiposity alters the properties of cardiac tissue is largely unknown. Extracellula...
Abstract 4366782: Pulmonary Hypertension Exhibits The Loss Of Capillaries, Leading To a Shift Toward Proliferative, Mesenchymal, and Hematopoietic Phenotypes
Background: Pulmonary capillary endothelial cells (ECs) are essential for lung function, maintaining vascular integrity, angiogenesis, and gas/nutrient exchange. Recent advances in...
Abstract 4362057: The Impact of Novel Lymphatic Interventions on Short- and Long-Term Outcomes of Chylothorax Following Pediatric Cardiac Surgery
Background: Chylothorax is as a complex disorder of abnormal lymphatic flow. Single ventricle (SV) patients are more susceptible due to altered venous and lymphatic pressures with...
Abstract 4371922: Femoral-Femoral Crossover Shunting Enhances Limb Perfusion During VA-ECMO
Introduction: Acute limb ischemia (ALI) is a common and serious complication in patients undergoing femoral veno-arterial extracorporeal membrane oxygenation (VA-ECMO), largely due...
Abstract 4370895: Combined left- and right-sided native valve infective endocarditis with no predisposing risk factors or intracardiac shunt
Combined left and right-sided Infective Endocarditis (IE) is rare and typically occurs with underlying predisposing factors such as intravenous drug use, presence of hemodialysis catheters, congenital...
Abstract 4357672: Discordantly Elevated Small Dense LDL-C Increases Risk of Cardiovascular Events in Hypertensive Adults: Insights from SPRINT
Background: Small dense low-density lipoprotein cholesterol (sdLDL-C) is highly atherogenic, yet its role in predicting cardiovascular disease (CVD) among individuals with hyperten...
Abstract 4363436: Changes in decisional conflict among adults with atrial fibrillation viewing a rhythm management decision aid: Results from a single-arm feasibility trial
Introduction: Shared decision-making is recommended for atrial fibrillation (AF) rhythm management. Decision aids improve patient satisfaction, care quality, and health outcomes. T...
Abstract 4339226: Does Vitamin D Supplementation Reduce New-Onset Atrial Fibrillation in Post-Coronary Artery Bypass Graft Patients in Vitamin D Deficient and Insufficient Populations? A Systematic Review and Meta-Analysis
Introduction: New-onset postoperative atrial fibrillation (POAF) is a common complication following coronary artery bypass grafting, with incidence ranging from 21% to 34%. Emergin...
Abstract 4341265: Impact of the MISSION Act on Quality and Outcomes of Major Cardiovascular Procedures Among Veterans
Introduction/Background: The Department of Veterans Affairs’ (VA’s) Maintaining Internal Systems and Strengthening Integrated Outside Networks (MISSION) Act expanded opportunities...
Abstract 4369706: Rising Toll: Alarming Trends in Ischemic Heart Disease Mortality and DALYs Across South Asia (1990–2021)
Introduction: Cardiovascular diseases (CVD) are the leading global cause of death, with 58% of related deaths occurring in Asia. Notably, over 80% of cardiovascular deaths are attr...
Abstract 4344613: Kidney Function, Subclinical Myocardial Injury, and their Joint Association with Cardiovascular Mortality in the General Population
Background: Impaired kidney function and subclinical myocardial injury (SCMI) carry significant mortality risk. However, their interrelationship as well as their combined impact on...
Abstract 4343983: <i>Hybrid Devices Rank First in Vascular Closure Outcomes After Transfemoral TAVR Access: A Bayesian Network Meta-Analysis of Randomized Controlled Trials</i>
Background: Transfemoral transcatheter aortic valve replacement (TAVR) is an established approach for treatment of symptomatic severe aortic stenosis. Various vascular closure devi...
Abstract 4370959: Cancer Independently Increased Stroke Incidence in Atrial Fibrillation Patients from 2015-2024
Introduction: Cancer induces a prothrombotic state through multiple mechanisms. Although patients with cancer are at increased risk of thromboembolism, stroke risk stratification t...