Circulation
Articles in this Issue
Abstract 4361739: Mortality Patterns of Atrial Fibrillation Among Adults with Renal Disease in the United States, 1999–2023: Evidence from the CDC WONDER Database
Background: Atrial fibrillation (AF) and renal diseases frequently coexist, posing significant challenges in clinical management. The interplay between these conditions can exacerb...
Abstract 4344466: Nobiletin inhibits atherosclerosis by regulating macrophage Bmal1 and Hif1α
Dysfunction of macrophage cholesterol homeostasis is a risk factor for atherosclerosis and metabolic disorders. We have shown that macrophage-specific Bmal1 (Brain and Muscle Arnt-like protein-1) defi...
Abstract 4342332: A Non-Contacting Blood Flow Sensor for Assessing Pediatric Vascular Graft Patency
Introduction: For infants born with single ventricle physiology, the initial palliation involves the implantation of a systemic to pulmonary vascular graft, typically a modified Bl...
Abstract 4336704: Evaluating the Efficacy and Safety of Iron Supplements for the Treatment of Iron Deficiency in Patients With Heart Failure: A Network Meta-Analysis
Background and Aim: Iron deficiency (ID) is a common condition worldwide, affecting about one-third of the population, and is particularly prevalent in heart failure (HF) patients....
Abstract 4371297: The effect of Remote Ischemic Conditioning in Acute Ischemic Stroke Treated with Intravenous Thrombolysis, systematic review and meta analysis
Background: Intravenous thrombolysis (IVT) improves outcomes in acute ischemic stroke (AIS), but many patients still do not achieve full recovery. Remote ischemic conditioning (RIC...
Abstract 4371369: Joint Associations of Social and Psychological Health Risk and Life’s Essential 8 among Women of Reproductive Age
Background: Cardiovascular risk factors are increasing among women of reproductive age, yet limited evidence exists on how co-occurring social and psychological burdens influence c...
Abstract 4366329: Comparative Cardiovascular Outcomes in Acalabrutinib vs Zanubrutinib in B-Cell Malignancies: A TriNetX Data Study
Background: Next-generation Bruton’s tyrosine kinase inhibitors (BTKis) such as acalabrutinib and zanubrutinib have improved treatment outcomes in B-cell malignancies including chr...
Abstract 4348719: Increased Cardiovascular Risk Following Hysterectomy: A Systematic Review and Meta-analysis
Background: Hysterectomy is one of the most commonly performed non-obstetric surgical procedures in women globally. However, the long-term cardiovascular effects of hysterectomy re...
Abstract 4369102: Unequal Declines in Cardiovascular Disease Burden by Socio-demographic Index: A Global Joinpoint Analysis
Background: While cardiovascular disease (CVD) burden has declined globally, it is unclear whether this progress has been equitable across development levels. The Socio-demographic...
Abstract 4370674: Cangrelor Versus Oral P2Y12 Inhibitors During PCI in Cardiogenic Shock and Cardiac Arrest: A Systematic Review and Meta-analysis
Background: Patients with cardiogenic shock or out-of-hospital cardiac arrest undergoing percutaneous coronary intervention face delayed absorption of oral P2Y12 inhibitors due to...
Abstract 4368833: A RETRO-ENANTIOMER OF ANGIOTENSIN-(1-9) PREVENTS THE DEVELOPMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION.
Background: Recently we described the first retro-enantiomer (RE) of the renin angiotensin system (RAS), a mimetic peptide of angiotensin-(1-9) [Ang-(1-9)RE]. It binds to the AT2 r...
Abstract 4371215: ANGPTL3 Targeting Monoclonal Antibodies Lead to Robust Reductions in LDL-C, Triglycerides, ApoB, and Non-HDL-C in Dyslipidemic Patients: A Meta-Analysis of 5 Randomized Controlled Trials
Introduction: Dyslipidemia remains a major driver of cardiovascular disease. Monoclonal antibodies (mAb) that block angiopoietin-like protein 3 (ANGPTL3) lower atherogenic lipids b...
Abstract 4361991: Analyzing Trends in Mortality due to Arterial Thromboembolism in the U.S.
Background: Thromboembolic disease is classified into 2 groups. Ischemic heart disease (IHD) and ischemic stroke comprise arterial thromboembolism (ATE), while deep venous thrombos...
Abstract Sun1404: The Calm Before the Collapse: A Hidden Left Main Coronary Catastrophe
Case Presentation: A 55-year-old male with a past medical history of hypertension, aortitis, focal seizures, migraines, and tobacco use presented with chest pain and shortness of b...
Abstract 4364753: Refining Atherosclerotic Risk Prediction in Patients with Systemic Sclerosis: Association with Uric Acid and the Creation of a Novel Scleroderma-Atherosclerotic Cardiovascular Disease Risk (ScleroRisk) Assessment Model
Introduction: Patients with systemic sclerosis (SSc) are known to have higher rates of atherosclerotic cardiovascular disease (ASCVD) compared to the general population. Without th...
Abstract 4369175: Changes in N-terminal pro-B-type natriuretic peptide and soluble suppressor of tumorigenicity-2 during the transition from hospital to home in heart failure
Background: Major goals during a hospitalization for heart failure (HF) are adequate decongestion and hemodynamic optimization to avoid worsening symptom burden and rehospitalizati...
Abstract 4367934: Comprehensive Genetic Analyses Combined with Animal Studies Provide New Insights into Genetic Modes of Outflow Tract Defects: A Large-Scale Japanese Investigation
Background: Persistent truncus arteriosus (PTA), pulmonary atresia with ventricular septal defect (PA-VSD) and tetralogy of Fallot (ToF) give a developmental spectrum of outflow tr...
Abstract 4371129: SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS IMPROVE RIGHT VENTRICULAR FUNCTION IN HEART FAILURE PATIENTS IN AN UPDATED META-ANALYSIS
Background: Right ventricle (RV) function is an independent predictor of major adverse cardiac events in patients with known or suspected cardiovascular disease. Sodium-glucose cot...
Abstract 4341368: Hepatic Retinol-Binding Protein 4 Mediates the Exacerbation of Myocardial I/R Injury in MAFLD mice through Augmented Oxidative Stress and Ferroptosis
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD), with a global prevalence of 25%, is increasingly linked to heightened coronary artery disease (CAD) risk,...
Abstract 4366319: Evaluating ChatGPT as a Patient Education Tool for Cardiovascular Medications: High Quality, Low Accessibility
Introduction: Cardiovascular diseases (CVDs) are the leading cause of death globally, yet medication nonadherence remains high. Artificial intelligence (AI) tools may help improve...
Abstract 4369642: Efficacy of Sodium-Glucose Transport Protein 2 Inhibitors in Prevention Atrial Fibrillation post - Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-Analysis
Introduction: Atrial fibrillation(AF) following coronary artery bypass graft is a prevalent complication often occurring 2-4 days postoperatively, characterised by brief asymptomat...
Abstract 4365079: Semaglutide Modulates the Cardio-Hepatic Axis By Mitigating Lipid and Fibrosis Deposition Independent of Weight Loss in Obese HFpEF
Introduction: Heart failure with preserved ejection fraction (HFpEF) is a prevalent and morbid syndrome strongly linked with obesity. The Glucagon-like Peptide-1 (GLP-1) agonists h...
Abstract 4371367: Three-Decade National and Subnational Trends in the Burden of Heart Failure Attributable to Chronic Kidney Disease in the United States, 1990–2021
Background: Chronic kidney disease (CKD) significantly amplifies the risk and complexity of heart failure (HF), yet national and state-level trends of HF burden attributable to CKD...
Abstract 4343195: Using Machine Learning Methods to Predict Adverse Events in Patients Undergoing Transcatheter Left Atrial Appendage Occlusion
Background: Cardiovascular risk models generally use standard statistical methods that limit their performance for common outcomes and don’t allow for prediction of rare outcomes....
Abstract 4370661: Cardiovascular Benefits of GLP-1 Receptor Agonists in Non-Obese Patients With Type 2 Diabetes, Chronic Kidney Disease, or Coronary Artery Disease: A Real-World TriNetX Analysis
Background: GLP-1 receptor agonists (GLP-1 RAs), originally approved for glycemic control and weight management in type 2 diabetes (T2D), have demonstrated cardiovascular (CV) bene...