Circulation
Articles in this Issue
Abstract 4343393: Impact of adverse events on clinical outcomes in patients with cardiogenic shock supported by temporary mechanical circulatory support devices
Introduction: Temporary mechanical circulatory support (tMCS) devices are often used in patients with cardiogenic shock (CS). Whether tMCS device-related adverse events (DRAEs) aff...
Abstract 4371228: Single-cell multiomic analysis identifies a gene regulatory network governing cardiac fibroblast activities after myocardial infarction and reveals the critical role of RUNX transcription factors
Background: After myocardial infarction (MI), cardiac fibroblasts (CFs) undergo stepwise differentiation into cardiac myofibroblasts (CMFs) and matrifibrocytes, supporting tissue r...
Abstract 4364102: Acoramidis Reduces All-Cause Mortality and Cardiovascular-Related Hospitalizations Through Month 42 in Transthyretin Amyloid Cardiomyopathy Across All Pre-specified Patient Subgroups
Introduction: Acoramidis, an oral transthyretin (TTR) stabilizer achieving near-complete (≥90%) TTR stabilization, is now approved in the USA, EU, Japan, and UK for the treatment o...
Abstract 4365249: Treatment Modality and Cardiovascular Mortality in Breast Cancer: A SEER and Single-Center Analysis by Stage and Receptor Subtype
Background: CV mortality (CVM) is a critical competing risk in breast cancer (BC). How therapy type affects CVM by stage and receptor subtype remains incompletely defined....
Abstract 4364966: A Novel Machine Learning-based Adverse Cardiovascular Events Risk Algorithm For Cancer Patients Treated With Tyrosine Kinase Inhibitors
Background: Cancer patients treated with tyrosine kinase inhibitors (TKIs) have an increased risk of adverse cardiovascular events (ACE). Traditional cardiovascular risk scores may...
Abstract 4354732: Longitudinal LDL-C Control Among Patients With ASCVD and Elevated Baseline LDL-C: Insights From the cvMOBIUS-2 Registry
Background: Prior cross-sectional studies have documented poor low-density lipoprotein cholesterol (LDL-C) control in patients with atherosclerotic cardiovascular disease (ASCVD);...
Abstract 4373203: Basic Tools and Big Impact: A Tele-assisted Home-based Cardiac Rehabilitation Model for LMICs
Background: Cardiac rehabilitation (CR) is a widely recommended evidence-based intervention for patients with cardiovascular (CV) diseases; it’s underutilized due to geographical,...
Abstract 4371273: Community Paramedic Home Visits for Heart Failure: Per-Protocol Analysis of the MIGHTy-Heart Trial
Background: Mobile Integrated Health (MIH) programs integrate nurse care coordination, community paramedic (CP) home visits, and telehealth visits with emergency medicine physician...
Abstract 4351043: Designing Medically Tailored Meal Interventions: The Food as Medicine For Families (FAME-F) Randomized Clinical Trial
Background: Medically tailored meals (MTM) are a promising Food is Medicine intervention but several implementation questions remain unanswered. Since food is shared, providing foo...
Abstract 4364571: Outcomes of Non-Cardiac Surgery Following Transcatheter Mitral Valve Replacement: A US Collaborative Network Cohort Study
Introduction: Transcatheter mitral valve replacement (TMVR) offers a less invasive alternative to traditional open-heart surgery for patients with mitral valve disease. Despite its...
Abstract 4338221: EVOLocumab Very Early after Myocardial Infarction (EVOLVE-MI): A Pragmatic Randomized Multicenter International Trial - Design and Baseline Characteristics
Introduction: Patients with myocardial infarction (MI) are at risk of recurrent coronary events. Studies have shown that PCSK9 inhibition can reduce LDL-C to very low levels decrea...
Abstract Sun1106: Dynamic components of CPR performance in a pediatric emergency department: a video-based study
Bakcground: Cardiac arrest in the pediatric emergency department (PED) is an uncommon event requiring rapid assembly of ad hoc multidisciplinary care teams. Effective cardiopulmona...
Abstract 4345465: CPSF7-Mediated Alternative Polyadenylation of CCNE2 Enhances the Regenerative Capacity of Human iPSC-Derived Cardiomyocytes for Myocardial Infarction Therapy
Background: The loss of cardiac regenerative capacity after birth remains a major barrier to effective heart repair. Alternative polyadenylation (APA) has emerged as a key post-tra...
Abstract 4371204: Nationwide Consensus of 800 Experts on Statin Combinations with Ezetimibe and Clopidogrel for Lipid Management and Cardiovascular Risk Reduction
Introduction: The AngioStat initiative aimed to establish expert consensus on statin combination strategies involving ezetimibe and clopidogrel, focusing on their clinical relevanc...
Abstract 4361454: Trends in Complications and Ill-defined Descriptions of Heart Diseases-Related Mortality in the United States; 1999-2020 – A CDC-WONDER Database Analysis.
Background: Heart disease continues to be the leading cause of death in the United States in 2025. Ill-defined descriptions of heart disease may lead to misclassification of deaths...
Abstract 4362447: Reduced vs Full Dose Direct Oral Anticoagulants in Extended Treatment of Venous Thromboembolism: A Systematic Review and Meta-Analysis
Background: Direct oral anticoagulants (DOACs) have been commonly used for extended treatment following an episode of Venous Thromboembolism (VTE) to reduce the recurrence rate. Ho...
Abstract 4363825: Colchicine as an Adjunct Therapy Following Catheter Ablation for Atrial Fibrillation: A Systematic Review and Meta-Analysis
Background: Atrial fibrillation (AF) recurrence following catheter ablation remains a significant clinical challenge, often attributed to post-procedural inflammation. Colchicine,...
Abstract 4367192: Lean Body Mass Index: A Valuable Predictor of Coronary Artery Disease Severity Stratified by the Computed Tomography–derived SYNTAX Score
Background: Body composition indicators (BCIs) are metrics for assessing the components of the body, such as waist circumference (WC), body mass index (BMI), lean body mass index (...
Abstract 4359392: Additive Value of Lipoprotein(a), Remnant Cholesterol, and Inflammation for Risk Stratification of Myocardial Infarction: Evidence from the UK Biobank
Background: Lipoprotein(a) [Lp(a)], remnant cholesterol (RC), and high-sensitivity C-reactive protein (hsCRP), a marker of systemic inflammation, are emerging non-traditional bioma...
Abstract 4370630: Troponin Thresholds May Not Be Equal: A Systematic Review of Sex-Based Diagnostic Performance in NSTEMI
Background: High sensitivity cardiac troponin is essential for diagnosing non-ST elevation myocardial infarction. However, the use of uniform thresholds may underdiagnose women due...
Abstract 4338677: Cardiometabolic Deaths in Premenopausal Black and White Women
Background: Black women in the United States experience a disproportionate burden of cardiometabolic disease (CMD) beginning in adolescence, although CMD mortality is often thought...
Abstract 4347593: An Updated Meta-analysis of Extended Thrombolytic Treatment Windows for Acute Ischemic Stroke
Background: Guidelines recommend intravenous thrombolysis (IVT) within 4.5 hours for acute ischemic stroke (AIS). Imaging-selected patients may benefit from IVT beyond this window....
Abstract 4370165: Prenatal Care and Perinatal Regionalization of Congenital Heart Defect Care
Background: Regionalization is the direction of patients to centers with appropriate levels of care and is key to optimizing outcomes. However, the role of prenatal care in perinat...
Abstract 4366465: Integrative Single-Cell and Genetic Profiling of Human Heart Failure for Therapeutic Target Discovery
Heart failure is a leading cause of morbidity and mortality worldwide, arising from a range of underlying cardiomyopathies, including myocardial infarction, hypertrophic, dilated, and arrhythmogenic f...
Abstract 4369127: Post-operative Delirium Incidence and Correlates in Cardiac vs Non-cardiac Surgeries
Background: Post-operative delirium (POD), characterized by an acute and fluctuating disturbance in mental status, is a common complication following surgery. Cardiac surgery, olde...