Circulation
Articles in this Issue
Abstract 4367648: Fish-Eye Disease: A Case Report
Description of Case: A 26-year-old female was referred to cardiology with bilateral corneal opacifications of four years’ duration, with no change in her visual acuity. Her workup...
Abstract 4369361: Extracellular Vesicles Enhance Cardiovascular and Protein Adaptations in Mice With Pulmonary Hypertension
Introduction: Extracellular vesicles (EV) mediate intercellular communication and may have effects on disease processes. R...
Abstract 4370120: Comparative Analysis of Clinical Outcomes Following Transcatheter Aortic Valve Replacement in Patients with Wild-Type Transthyretin Amyloidosis: A Multicenter TriNetX Study
Background: Wild-type transthyretin amyloidosis (ATTR) is an underrecognized contributor to aortic stenosis, and its presence may influence procedural outcomes after transcatheter...
Abstract 4367162: Risk of Gastrointestinal Bleeding by Mechanical Circulatory Support Device
Introduction: Gastrointestinal bleeding (GIB) is a common, potentially modifiable, complication in patients receiving mechanical circulatory support (MCS) but head-to-head data for...
Abstract 4363467: Real World Experience of Intravenous Iron Repletion in Children with Heart Failure
Introduction: Iron deficiency (ID) is common in HF and is associated with adverse CV outcomes. There is a paucity of literature on efficacy of intravenous iron replacement (FeIV) i...
Abstract 4371606: Effect of Long-term Melatonin Supplementation on Incidence of Heart Failure in Patients with Insomnia
Background: Chronic insomnia affects up to one-third of adults, and over-the-counter melatonin is increasingly promoted as a “cardiometabolic-friendly” sleep aid. Robust data on it...
Abstract 4348032: Digital Twins Enable Noninvasive Prediction of Roof-Dependent Atrial Tachycardia Occurrence Following Pulmonary Vein Isolation
Background: Pulmonary vein isolation (PVI), the gold-standard treatment for atrial fibrillation (AF), is often insufficient for persistent AF (PsAF). In this context, pulsed field...
Abstract 4350351: Impact of Aorto-Mitral Length on Aortic Valve Following Mitral Valve Surgery
Introduction: Advancements in cardiac imaging technology have enabled the acquisition of detailed anatomical information. The mitral valve is anatomically adjacent to the aortic va...
Abstract 4370961: Neighborhood Level of Incarceration and Prevalence of Cardiometabolic Diseases: Evidence from Path Analysis
Background: Incarceration is associated with worse cardiometabolic health at the individual level; however little has been done to examine pathways accounting for structural racism...
Abstract 4364900: Novel Echocardiographic Strain Analysis Enables Mapping of Myocardial Fiber Contraction Patterns: A Case Study in Pulmonary Hypertension
Background: Cardiac strain analysis is an effective method for diagnosing subclinical myocardial diseases and for follow-up assessments. Echocardiography is used for noninvasive st...
Abstract 4363001: Role of E2F Transcription Factor 1 in the Pathogenesis of Pulmonary Arterial Hypertension
Background: Dysregulated expression of transcription factors plays a key role in vascular remodeling and the development of pulmonary arterial hypertension (PAH). E2F1 is a central...
Abstract 4369873: <i>LPA</i> -Targeted siRNAs Lower Lp(a) by Over 90%: A Meta-Analysis of Olpasiran, Lepodisiran, and Zerlasiran
Introduction: Elevated lipoprotein(a) [Lp(a)] is a genetically determined, independent risk factor for atherosclerotic cardiovascular disease (ASCVD). Currently, no approved therap...
Abstract 4360198: PREVENT Heart Failure Equations Underpredict Physician-Adjudicated Heart Failure Events Among People with HIV in the Multi-Center CNICS Cohort
Background: HIV infection is associated with increased risk of heart failure (HF). The American Heart Association recently developed the Predicting Risk of Cardiovascular Events (P...
Abstract 4346906: Clinical Trials for Transthyretin Amyloid Cardiomyopathy: Where Demographics Diverge from Disease
Introduction: Underrepresentation in clinical trials remains a significant obstacle to achieving equitable healthcare outcomes. In an effort to promote transparency and inclusivity...
Abstract 4370781: Membrane-Repairing LncRNA Masir Protects the Heart from Ischemic Injury
Background: Cardiomyocytes (CMs) undergo constant mechanical stress during contraction and are vulnerable to membrane damage. Impaired sarcolemmal integrity is a key factor of hear...
Abstract Sun102: Impact of reversed airflow on ventilation volume and waveform capnography during manual chest compressions
Introduction: During cardiopulmonary resuscitation (CPR), continuous chest compressions cause retrograde movement of gases during the inspiratory and expiratory phases of ventilati...
Abstract 4365430: Cumulative exposure to low-density lipoprotein cholesterol levels explains the cardiovascular benefit over time in randomized clinical trials
Introduction: It is well-established that lowering low-density lipoprotein cholesterol (LDL-C) levels is associated with cardiovascular risk reduction, with clinical benefits incre...
Abstract 4369041: Remote Time-Restricted Eating and Mindfulness Pilot Intervention Improves Cardiovascular Disease Risk Markers in Young Adults with Obesity
Hypothesis: The concurrent implementation of time restricted eating (TRE) and a Mindfulness intervention yields superior outcomes in cardiovascular disease risk markers and stress...
Abstract 4369138: 25-Year Decline in Aortic Aneurysm and Dissection Mortality in the U.S.: Impact of Endovascular Repair and Forecast to 2030
Introduction: Aortic aneurysm and dissection are rare but life-threatening conditions, with an incidence of 5–30 cases per million annually. The introduction of endovascular aneury...
Abstract 4369704: Racial, Gender, and Comorbidity Predictors of Cardiovascular Mortality in Class III Obesity: Insights from the National Inpatient Sample
Background: Class III obesity (BMI ≥40 kg/m2) represents a growing public health challenge and is closely associated with cardiovascular disease (CVD). This study investigates clin...
Abstract 4367829: Assessing Mitochondrial Viability Under High-Calcium Stress: Relevance to Intracoronary Therapeutics
Background: Extracellular calcium above basal cytosolic levels disrupts mitochondrial homeostasis, causing swelling, inner membrane breakdown, loss of membrane potential, and reduc...
Abstract 4366350: Ten-Year Survival in AL Cardiac Amyloidosis: Does Mayo Staging still matter in the Recent era?
Introduction: AL cardiac amyloidosis (AL-CA) is associated with poor prognosis, largely driven by cardiac involvement. The revised Mayo staging system utilizes cardiac biomarkers t...
Abstract 4366733: Deep Learning-Based BNP Classification from Single-Lead ECG
Background: Brain natriuretic peptide (BNP) is a key heart failure biomarker. Single-lead electrocardiograms (ECGs) from wearable devices offer valuable diagnostic and prognostic i...
Abstract 4348886: The Safety of Non-invasive Ventilation in Cardiogenic Shock: A Systematic Review and Meta-analysis
Background: Cardiogenic shock is associated with high mortality and usually requires ventilatory support. Non-invasive ventilation (NIV) has demonstrated benefits in cardiogenic pu...
Abstract 4366879: Does Knowledge of Anti-Ro Antibody Status Before Pregnancy Affect Diagnosis of Fetal Cardiac Neonatal Lupus? A Fetal Heart Society Research Collaborative Study
Introduction: Fetal cardiac neonatal lupus (CNL) due to maternal anti-Ro antibodies (anti-Ro Ab) manifests as atrioventricular block (AVB) and/or extranodal cardiac disease. Despit...