Circulation
Articles in this Issue
Abstract 4362546: Non-Contrast Coronary Artery Imaging with a Novel High Frequency Optical Coherence Tomography
Background: Intracoronary optical coherence tomography (OCT) is widely utilized for high-resolution imaging of coronary arteries, but it requiring contrast agents to displace blood...
Abstract 4365044: Trends and Disparities in Stroke-Related Mortality among Heart Failure Patients in the United States, 1999-2020.
Background: Stroke is a leading cause of death in patients with heart failure (HF), but national trends and disparities in stroke-related mortality within this population remain po...
Abstract 4347517: Potential Patient Eligibility for Hospital at Home for Management of Worsening Heart Failure in the United States
Introduction/Background: Hospital at Home (HaH) is an emerging, patient-centered clinical model by which patients receive inpatient-level care at home. HaH may be particularly well...
Abstract 4372164: cBIN1 Gene Therapy Delivered Intramyocardially in Left Ventricle Attenuates Right Ventricular Structural Remodeling in a Canine Model of Dilated Ischemic Cardiomyopathy
Introduction: Myocardial infarction is a common cause of heart failure (HF), leading to scar tissue formation and increased stress on the cardiac muscle, which affects atrial and v...
Abstract Sun1002: Novel Method of Oxygen Delivery with Oxygen Nano- and Microbubbles in Saline
Background: Hypoxemia is a leading cause of cardiac arrest and is associated with poor outcomes. Emergency treatments that do not rely on the failing lung are limited. We developed...
Abstract Sun406: Initial and Persistent STE-aVR following return of spontaneous circulation after out-of-hospital cardiac arrest: Limited Diagnostic Utility for PCI
Background: ST-segment elevation in lead aVR (STE-aVR) has been associated with left main coronary artery disease or severe multivessel coronary disease in non-arrest populations....
Abstract 4362912: Spatial transcriptomics identifies neurotrophin signaling in mural cell specification
Vascular smooth muscle cells and pericytes are mural cells that maintain the integrity and support the function of blood vessels. The molecular mechanism underlying the specification of pericytes and...
Abstract 4339624: Pericardial Tamponade Physiology in a Rare Case of Primary Mediastinal Embryonal Carcinoma: Diagnostic and Management Challenges
Primary mediastinal embryonal carcinoma is an exceptionally rare and aggressive extragonadal germ cell tumor, comprising less than 2% of mediastinal germ cell neoplasms. Cardiovascular complications,...
Abstract 4367171: Dual Risk of Bleeding and Thrombosis in Thrombophilia Patients Undergoing Transcatheter Edge-to-Edge Mitral Valve Repair: A Multicenter Real-World Analysis
Background: Patients with thrombophilia undergoing transcatheter edge-to-edge mitral valve repair (M-TEER) represent a clinical challenge due to elevated risks of both thrombotic a...
Abstract 4363437: Stereotactic Body Radiotherapy for Refractory Ventricular Tachycardia in Patients with Left Ventricular Assist Devices
Background: Patients with left ventricular assist devices (LVADs) may develop ventricular tachycardia (VT) refractory to conventional antiarrhythmic strategies. Catheter ablation i...
Abstract 4362348: A Case of Concomitant Wild-Type Transthyretin and Systemic Light Chain Amyloidosis Involving Separate Organs
Description of Case: A 72-year-old man with atrial fibrillation and spontaneous bicep rupture presents as a referral to clinic for a 2-year history of progressively worsening dyspn...
Abstract 4362033: <i>APOH</i> plays a distinct role in lipid trait dysregulation and increased CVD risk
Background: Variants at the APOH genomic locus have been associated with lipid traits, Lp(a), coagulation traits, coronary artery disease, a...
Abstract 4344227: Flux Balance Analysis Predicts Cardio-Metabolic Benefits of Food Products in Cancer Patients
Cardiovascular disease (CVD) and cancer are the leading causes of morbidity and mortality in the U.S. Diet is a significant risk factor for both CVD and cancer and has been shown to influence survival...
Abstract 4367898: Mechanisms and Anatomical Localization of Left Atrioventricular Valve Regurgitation Following Atrioventricular Canal Defect Repair Using Two- and Three-Dimensional Echocardiography
Background: Left atrioventricular valve regurgitation (LAVVR) after atrioventricular canal (AVC) defect repair remains a significant contributor to morbidity and mortality, and oft...
Abstract 4373195: A Novel Framework for End-Diastolic and End-Systolic Frame Localization in Contrast and Non-Contrast Echocardiography Without Manual Annotations
Background: End-diastolic (ED) and end-systolic (ES) frames are critical for left ventricular (LV) volume measurements in echocardiography but show high inter- and intra-observer v...
Abstract 4372991: Deep Learning Models Enhance Prediction of Sudden Cardiac Death in Pediatric Hypertrophic Cardiomyopathy: A Systematic Review and Meta-Analysis
Background: Sudden cardiac death (SCD) is a devastating event in pediatric hypertrophic cardiomyopathy (HCM), where risk stratification remains clinically challenging. Deep learnin...
Abstract 4369167: Impact of a Familial Hypercholesterolemia Education Initiative on Use of Lipid Lowering Treatment: the CARE-FH Study
Backround: Undertreatment of elevated LDL-Cholesterol (LDL-C) is a national public health issue. The Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia (CA...
Abstract 4365021: Sympathetic Denervation as a Substrate for Persistent Atrial Fibrillation Assessed Using 11C-Hydroxyephedrine PET Imaging
Background: Atrial fibrillation (AF) is the most common arrhythmia, associated with increased risks of stroke, heart failure, and mortality. Structural and autonomic remodeling con...
Abstract 4359566: Multimodal Imaging Characterization of Chronic Cardiac Pathologies in Aged Cynomolgus Monkeys: Translational Insights into Heart Failure and Amyloidosis
Background: Non-human primates (NHPs), particularly aged cynomolgus monkeys, share key physiologic, metabolic and genetic similarities with humans, offering valuable translational...
Abstract 4357661: Outcomes of Ventricular Tachycardia Ablation in Patients with Baseline Noninducibility
Background: Ventricular tachycardia (VT) induction identifies targets for ablation and is an important procedural endpoint. Ablation approaches and outcomes for patients noninducib...
Abstract 4348190: Cardiorenal Syndrome Type 1 complicated by Uremic Pericarditis and Small Pericardial Effusion causing Cardiac Tamponade
Introduction/Background: Cardiac tamponade is typically associated with large pericardial effusions; however, even small effusions can result in significant hemodynamic compromise,...
Abstract 4369467: The Association of Area Deprivation Index with Incident Chronic Hypertension in the Postpartum Period
Introduction: The development of chronic hypertension (HTN) in the postpartum period increases cardiovascular disease risk later in life. Area Deprivation Index (ADI) is a validate...
Abstract 4360270: Catheter-Directed Thrombolysis is Associated with Lower Cost and Similar Mortality Compared to Mechanical Thrombectomy in High-Risk Pulmonary Embolism
Introduction: High-risk pulmonary embolism (PE), defined as acute PE with associated hemodynamic instability, is a life-threatening condition with in-hospital mortality rates of up...
Abstract 4371536: Unveiling the Silent Killer: Undiagnosed Hypertension Drives 12,400 Annual Deaths with Disparities in Young Black Men and Rural Populations
Background: Hypertension affects approximately 45% of US adults, with an estimated 11–15% of cases undiagnosed. The mortality burden of undiagnosed hypertension has not been well-q...
Abstract 4367191: Cardiovascular Safety of Semaglutide: An Updated Systematic Review and Meta-analysis with Focus on Sex, Race, and Renal Function
Background: This updated systematic review and meta-analysis was conducted to provide comprehensive and reliable conclusions regarding the cardiovascular safety of semaglutide, wit...