Circulation
Articles in this Issue
Abstract 4364989: Antithrombotic Strategy and Long-term Outcome In dialysis patients with coexisting acute coronary syndrome and atrial fibrillation: a nationwide study
Background: Dialysis patients with both acute coronary syndrome (ACS) and atrial fibrillation (AF) face high thrombotic and bleeding risks. The optimal antithrombotic strategy and...
Abstract 4366986: Hyperammonemia during exercise as a cause of prolonged post-exertional fatigue in a Post- COVID Patient
Background: Post-COVID syndrome may present with exertional symptoms that are not explained by noninvasive testing. Invasive cardiopulmonary exercise testing (iCPET) can identify u...
Abstract 4369373: Real-World Sudden Cardiac Death Risk Prediction in Hypertrophic Cardiomyopathy Using State-of-the-Art Thinking Models
Background: Sudden cardiac death (SCD) is a leading cause of mortality in patients with hypertrophic cardiomyopathy (HCM). Currently, calculating the 5-year SCD risk score is manua...
Abstract 4367501: Genome Scale Metabolic Modeling Predicts Drug Cardiotoxicity in Human Cardiomyocytes
Background: Drug-induced cardiotoxicity is a major cause of clinical trial failures and post-market drug withdrawals. Current screening methods rely primarily on cell assays and tr...
Abstract 4366525: International JPH2 Registry: The Penetrance and Phenotypic Spectrum of <i>JPH2</i> -mediated Cardiac Disease
Background: Variants in JPH2 -encoded junctophilin 2 have been associated with a range of cardiac diseases, including hypertrophic cardiomyo...
Abstract 4367187: Incidental Detection and Coil Embolization of a Calcified Left Main Coronary Aneurysm with Severe Proximal LAD Compression Using Coronary CTA
Introduction: Left main coronary artery (LMCA) aneurysms are exceedingly rare, accounting for only 0.1% of all coronary anomalies. Their detection is often missed on conventional i...
Abstract 4367288: Effect of Myocardial Scar Burden on Blood-Tissue Interaction in Chronic Myocardial Infarction
Background: Hemodynamic force (HDF) analysis calculates intraventricular pressure gradients using blood volume geometry and velocity data derived from cardiac magnetic resonance (C...
Abstract 4344929: Advanced Imaging for STEMI Mimicry: Diagnosing Myopericarditis in HIV
Introduction: Acute myopericarditis can mimic acute myocardial infarction (AMI) on electrocardiogram (ECG), especially in patients with underlying cardiovascular disease. This diag...
Abstract 4371366: Permanent Pacemaker Implantation after TAVR and Long-Term Clinical Outcomes: A Systematic Review and Meta-Analysis
Background: Permanent pacemaker implantation (PPI) is a common outcome following transcatheter aortic valve replacement (TAVR), but its impact on long-term clinical outcomes remain...
Abstract 4363820: Comprehensive analysis of the regulatory mechanisms of mammalian cardiomyocyte proliferation revealed that Myomesin 2 inhibits cardiomyocyte proliferation.
Background: Since mammalian cardiomyocytes (CMs) are terminally differentiated cells that have largely lost their proliferative capacity, the heart has limited regenerative capacit...
Abstract 4367136: CAR-T Therapies Associated with Higher CRS-Linked Cardiotoxicity Signal than BiTE Agents in Multiple Myeloma: Analysis of Adverse Event Report
Background: Chimeric antigen receptor T-cell (CAR-T) and bispecific T-cell engager (BiTE) therapies are T-cell engaging treatments with expanding indications in hematologic maligna...
Abstract 4366391: Compliance, ECG quality, and engagement with a smartphone app in patients with in-clinic compared with home-based, self-applied long-term continuous ECG patch monitors
Background: Long-term continuous ambulatory cardiac monitoring (LTCM) is a widely used diagnostic tool for arrhythmia detection, outperforming other modalities. COVID-19 accelerate...
Abstract 4366567: Temporal Patterns and Regional Disparities in Congenital Heart Anomalies Across the European Union from 1990-2021: A Benchmarking Global Analysis
Background: Congenital heart anomalies (CHA) remain one of the leading causes of childhood morbidity and mortality worldwide, with significant implications for long-term health out...
Abstract 4339113: Promoting the Thrombosis-Induced Alox15 Pathway for the Treatment of Inflammatory Lung Injury
Introduction: There are no effective treatments for sepsis-induced acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). ALI/ARDS patients exhibit increased incide...
Abstract Sun1303: Empowering Hearts to Save Lives: Impact of an Interactive Public Education Campaign During American Heart Month
Introduction: Sudden cardiac arrest (SCA) is a leading cause of death in the United States, with approximately 356,000 out-of-hospital cases annually. Despite its prevalence, bysta...
Abstract 4364278: Area-Based Social Risk Measures and In-Hospital Mortality: A Comparative Modeling Study in Coronary Artery Disease Patients
Introduction: While risk prediction of cardiovascular outcomes, including in-hospital mortality, increasingly incorporates social determinants of health (SDOH), it remains unclear...
Abstract 4358255: Three-Dimensional Principal Strain Analysis of Children with Duchenne Muscular Dystrophy Can Detect Early Changes in Left Ventricular Contraction
Background: Principal strain (PS) analysis offers a novel approach for evaluating the three-dimensional deformation of the left ventricle (LV) using 3D speckle-tracking echocardiog...
Abstract 4366955: Acute Inferolateral STEMI as an Initial Presentation of Polycythemia Vera with Recurrent Coronary Thrombosis Despite Triple Therapy
Case: A 60-year-old man with history of hypertension, diabetes, and remote history of unprovoked lower extremity DVT presented with dyspnea for 3 days and chest pain for 1 day. Ini...
Abstract 4360144: Effectiveness of Elective Endovascular Intervention for Patients with Peripheral Arterial Disease and Intermittent Claudication
Introduction: Peripheral vascular intervention (PVI) is increasingly used for the treatment of peripheral arterial disease (PAD) with intermittent claudication (IC). Large, real-wo...
Abstract 4373495: Demographic Inequities in Catheter Ablation Among SVT Hospitalizations: An Analysis of the Nationwide Inpatient Sample Database
Background: Catheter ablation is a guideline-directed therapy for symptomatic supraventricular tachycardia (SVT), yet disparities in its utilization across patient populations rema...
Abstract 4365663: Proteome-wide analysis of cardiac structure, function, and heart failure phenotypes using Mendelian Randomization
Introduction: Heart failure (HF) is a complex, heterogeneous disease. Identifying circulating proteins linked to cardiac structure, function, and HF subtypes may reveal new therape...
Abstract 4365054: Multi-Omics Analysis for Pathogenesis and Therapeutic Target in Thoracic Aortic Aneurysms
Purpose: Thoracic Aortic Aneurysm (TAA) is a significant public health concern. We aimed to identify drug targets and understand the pathogenic mechanisms of TAA....
Abstract 4342855: Comparative Effectiveness of Cardiac Rehabilitation After Surgical Aortic Valve Replacement – A Target Trial Emulation
Background: Cardiac rehabilitation (CR) after surgical aortic valve replacement (SAVR) is recommended by guidelines, but participation is low. This is partly because the supporting...
Abstract 4359171: Long-Term Outcomes of Obstructive Hypertrophic Cardiomyopathy Undergoing Surgical Myectomy: Is an Earlier Intervention Better?
Background: Surgical myectomy (SM) is recommended to relieve left ventricular outflow tract obstruction (LVOTO) in symptomatic obstructive hypertrophic cardiomyopathy (oHCM) patien...
Abstract 4357028: Psychosocial Stressors and Maternal Cardiovascular and Multisystem Morbidity in the Fourth Trimester: A 15-Year Propensity-Matched Analysis from a Nationwide EHR Network
Background: The fourth trimester—the postpartum year—is a critical window for maternal health, particularly among populations facing psychosocial stressors. While adverse SDOH are...