Circulation
Articles in this Issue
Abstract 4367002: The Starved Heart: Pericarditis in Extreme Anorexia Nervosa
Background: Anorexia nervosa (AN) is a psychiatric disorder defined by restrictive eating, fear of weight gain, and distorted body image, with a lifetime prevalence of ~4% among fe...
Abstract 4364919: Association of Antiphospholipid Syndrome with Infective Endocarditis and Staphylococcal Sepsis: A U.S. Nationwide Inpatient Sample Analysis
Background: Antiphospholipid syndrome (APS) predisposes patients to thrombosis and cardiac valve lesions (e.g., Libman-Sacks endocarditis). These vegetations, though sterile, may s...
Abstract 4370881: Elevated Pulmonary Artery Wedge Pressure at Transcatheter Pulmonary Valve Replacement: Clinical and Prognostic Associations
Background: Heart failure (HF) is the leading cause of mortality in adults with congenital heart disease (CHD) after transcatheter pulmonary valve replacement (TPVR), likely due to...
Abstract 4370739: Integrative analysis of MoTrPAC and LINCS transcriptomes identifies cardiovascular-relevant exercise-mimetic drugs
Introduction: Exercise is a cornerstone of cardiovascular health, yet not all individuals can engage in sufficient physical activity. Identifying pharmacological agents that mimic...
Abstract 4371491: <i>Clinical and Demographic Predictors of Surgical Intervention in a Multidisciplinary Lymphedema Program: A Vascular Medicine Perspective</i>
Introduction: Lymphedema is increasingly recognized as a condition best served within multidisciplinary care models. Identifying patient characteristics associated with surgical co...
Abstract 4367453: External Validation of an AI-ECG algorithm for Occlusive Myocardial Infarction Detection in a General Chest Pain Population
Background: Nearly one-third of patients with Acute Coronary Syndrome have an acute coronary occlusion without diagnostic ST elevations (STE) that often goes unrecognized, leading...
Abstract 4365806: <i>Patient and Procedural Characteristics Associated with GERD and Chest Pain After Atrial Fibrillation Ablation with Esophageal Cooling: Results from the Multicenter EVERCOOL AF Registry.</i>
Background: Gastroesophageal reflux disease (GERD) and chest pain are common complications following catheter ablation for atrial fibrillation (AF), often attributed to esophageal...
Abstract 4366534: Mortality risk and procedural complications with general anesthesia compared to monitored anesthesia care in percutaneous LAAo: A Propensity-Matched Real-World Analysis
Introduction: During percutaneous LAAo, intraprocedural guidance with TEE and fluoroscopy is the standard of care. While general anesthesia with intubation (GA) has historically be...
Abstract 4364982: Serum GUDCA Alleviates Cardiac Injury in Acute Myocardial Infarction by Promoting Regulatory T Cell Differentiation
Background: Regulatory T cells (Tregs) exert protective effects following acute myocardial infarction (AMI), yet their levels decline rapidly after injury. Although serum metabolit...
Abstract 4367271: Sex and Racial Disparities in Atherosclerotic Heart Disease Mortality Among Older Adults in the United States: A CDC WONDER Database Analysis (1999–2020)
Background: Atherosclerotic heart disease (ASHD) remains a leading cause of death among older adults in the United States. However, disparities in ASHD-related mortality by sex and...
Abstract 4365077: Subclinical Inflammatory Biomarker Profiles and Associations with Future Chronic Inflammatory-Related Disease and Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosis
Background: Inflammation is associated with cardiovascular diseases (CVD). We previously described Chronic Inflammatory-Related Disease (ChrIRD), a composite of non-cardiovascular,...
Abstract 4339180: The Proof is in the Pillbox: An Elusive Case of Cardiomyopathy
A 63-year-old female with mixed connective tissue disease on long-term immunosuppression (prednisone, azathioprine, hydroxychloroquine (HCQ)) was referred to a tertiary care center for evaluation of p...
Abstract 4366937: Cavo-Tricuspid Isthmus Ablation in Atrial Flutter with Uncorrected Ebstein’s Anomaly: A Scoping Review
Background: Ebstein’s anomaly (EA) is a rare congenital heart defect characterized by apical displacement and abnormal development of the tricuspid valve, resulting in right atrial...
Abstract 4342725: Prognostic value of aldosterone for incident cardiovascular disease and mortality in the population-based Gutenberg Health Study
Background: Dysregulated aldosterone is a modulator for the development and progression of cardio-renal-metabolic disease. Aim: This study aime...
Abstract 4368215: Long-Term Clinical Outcomes between P2Y12 Inhibitor Monotherapy and Prolonged Dual Antiplatelet Therapy in Patients with Poly-vascular Disease: Sub-study of the SMART-CHOICE Randomized Trial
Background: The optimal antiplatelet treatment strategy for poly-vascular disease after percutaneous coronary intervention (PCI) is uncertain....
Abstract 4345579: Once Weekly Utreglutide (GL0034), a Glucagon-like Peptide-1 Receptor Agonist Reduces Liver Fat Content along with Blood Pressure in Post-menopausal Females with Obesity: A Phase 1a/2b Study
Background: Utreglutide (GL0034, UTG), a novel, once weekly glucagon-like peptide-1 receptor agonist (GLP-1RA), demonstrated clinically relevant reductions of systolic and diastoli...
Abstract 4368357: Comparative 2 Year Outcomes of Carvedilol Versus Metoprolol Succinate initiation in Heart failure with reduced ejection fraction Patients with End-Stage Renal Disease on Dialysis: A Propensity- Matched analysis
Background: Heart failure with reduced ejection fraction (HFrEF) in patients with end-stage renal disease (ESRD) on dialysis is associated with high morbidity and mortality. it rem...
Abstract 4362320: Relationship between the Cardiovascular-Kidney-Metabolic Syndrome Stages and Cardiovascular Adverse Outcomes in the Beijing Community Population
Background: Among Asian populations, there have been limited reports on the impact of cardiovascular-kidney-metabolic (CKM) syndrome stages on adverse cardiovascular outcomes. This...
Abstract 4360678: Intravenous Administration of Muse Cells Promotes Long-Lasting Functional Recovery in a Rat Model of Spinal Cord Ischemic Injury
Introduction: Spinal cord ischemic injury (SCII) is a devastating complication of aortic surgery that often leads to irreversible motor dysfunction. Despite its clinical severity,...
Abstract 4357798: Risk assessment in primary prevention: plaque matters most
Background: Cardiovascular disease (CVD) risk stratification in primary prevention involves risk factor-based calculators. Subclinical atherosclerosis (SA) disease burden represent...
Abstract 4342945: The Diagnosis of Vasovagal Syncope Requires an Extended Duration of the Head-Up Tilt Table Test
Background: Vasovagal syncope (VVS) is a type of reflex syncope in which transient loss of consciousness is caused by reflex vasodepression and/or cardioinhibition leading to cereb...
Abstract 4370383: Cannabidiol alleviates fibrosis through AGE-RAGE axis inhibition in a Non-Ischemic Mouse Model of Heart Failure
Background: Cannabidiol has been shown recently to improve cardiac function in mouse models of heart failure with a potential mechanism through influencing mitochondrial bioenerget...
Abstract 4366521: PREVENT Outperforms Pool Cohort Equation in Predicting 10-Year Cardiovascular Risk in a National Cohort
Introduction: PREVENT is a new prediction tool used for cardiovascular risk management. The purpose of this study was to investigate whether the PREVENT risk score is more accurate...
Abstract 4361884: Improvement in Echocardiographic Measures of Diastolic Function Reflects Improved Exercise Performance in Obstructive Hypertrophic Cardiomyopathy: Insights From the SEQUOIA-HCM Trial
Background: A hallmark feature of obstructive hypertrophic cardiomyopathy (oHCM) is impaired exercise capacity, which impacts quality of life and is a determinant of clinical outco...
Abstract 4350460: COVID-induced TNF receptor-associated periodic syndrome: a case of refractory microvascular angina resolved with anti-interleukin-1 therapy by multimodality imaging
Background: Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is a rare autoinflammatory condition associated with recurrent episodes of fever, chest pain,...