Circulation
Articles in this Issue
Abstract 4370399: Trends in Lipoprotein Metabolism Disorder–Associated Cerebrovascular Disease Mortality in the United States, 1999–2023: An Analysis from the CDC WONDER Database
Background: Cerebrovascular disease (CVD) mortality is considerably influenced by disorders of lipoprotein metabolism (LMD). While hypercholesterolemia is a recognised risk factor...
Abstract 4361136: Mitral Transcatheter Edge-to-Edge Repair in Patients with Severe Pulmonary Hypertension
Background: There is little evidence regarding mitral transcatheter edge-to-edge repair (TEER) in the setting of severe pulmonary hypertension (PH), defined by an estimated pulmona...
Abstract 4363398: Comparing Cardio-renal Outcomes of Finerenone versus Steroidal Mineralocorticoid Receptor Antagonist in Heart Failure with Reduced Ejection Fraction and Chronic Kidney Disease
Introduction: Finerenone is a selective non-steroidal mineralocorticoid receptor antagonist (MRA) approved by FDA in 2021 for reducing the progression of albuminuria in patients wi...
Abstract 4368955: Endothelial Cell-Specific MnSOD Overexpression Ameliorates Right Ventricular Hypertrophy in Pulmonary Hypertensive Mice
Background: Increased mitochondrial ROS is a known contributor to endothelial cell (EC) dysfunction, which plays a major role in the development and progression of pulmonary hypert...
Abstract 4369416: Impact of Long COVID on Physical Activity and Sleep: a Matched Cohort Study using Wearable and EHR data From The All of Us Research Program
Backround: Long COVID (LC) is associated with negative health effects, but its impact on health behaviors such as activity and sleep remains unclear. Using data from the All of Us...
Abstract 4369909: Association of right ventricular size and function parameters in Hodgkin and Non-Hodgkin Lymphoma with obesity and cardiovascular risk factors: What matters the most?
Introduction: Anthracycline-induced left ventricular dysfunction is well documented in lymphoma patients. However, the impact of cardiovascular risk factors (CVRF) and obesity on t...
Abstract 4370351: Restoring Microglial Homeostasis Decreases Sympathoexcitation in Chronic Kidney Disease
Introduction: Sympathoexcitation is a central diver of cardiovascular mortality in patients with chronic kidney disease (CKD). However, the molecular mechanisms underlying excess s...
Abstract Sun205: Study on the Role of CTRP7 in Aggravating Brain Injury after Cardiopulmonary Resuscitation
Background: C1q/TNF-related protein 7 (CTRP7), a significant adipokine primarily secreted by adipocytes, serves as a key effector molecule in vascular remodeling signaling pathways...
Abstract 4370048: Aging-Associated Lymphatic Dysfunction Drives Cardiac Injury During Chronic H1N1 Infection
Introduction: Viral respiratory infections (VRIs) are linked to cardiovascular complications that are more severe in the elderly, yet mechanistic understanding and therapeutic stra...
Abstract 4370417: Racial Disparities in Major Adverse Cardiovascular Events Among Dementia Patients: A National Inpatient Sample Analysis (2016-2021)
Background: Racial disparities in health outcomes are well-documented, yet their impact on major adverse cardiovascular and cerebrovascular events (MACCE) in patients with dementia...
Abstract 4362168: Redefining Vasoplegia: A New Hemodynamic Model for Differentiating Cardiac vs Vascular Dysfunction using the Resistance Flow Ratio
Background: Traditional definitions of vasoplegia, based on fixed thresholds of mean arterial pressure (MAP), cardiac index (CI), and systemic vascular resistance (SVR), fail to ac...
Abstract 4368423: Feasibility and Outcomes of Shockwave Intravenous Lithotripsy as an Adjunctive Tool in Complex Transvenous Lead Extraction
Introduction: Transvenous lead extraction (TLE) of old leads is associated with increased procedural complexity and risk due to the development of calcified vascular adhesions. Thi...
Abstract 4362955: Polygenic Risk Score Associated With Kidney Disease Progression In Patients With Cardiometabolic Risk Factors
Background: Chronic kidney disease (CKD) is associated with significant morbidity and mortality, especially in patients with concurrent heart disease who share many similar risk fa...
Abstract 4341994: Penetrance of Cardiomyopathy-Associated Variants in a Population-Based Cohort Supports ClinGen Gene Validity Classifications
Introduction: Cardiomyopathies, including hypertrophic (HCM) and dilated (DCM), are heterogeneous heart muscle disorders contributing significantly to heart failure, arrhythmias, a...
Abstract 4371743: Rethinking Healthy Grocery Stores: Misalignment Between Shopper Beliefs and Product Nutrition
Background: Grocery stores are considered the gold standard consumer source for healthful foods and an answer to food deserts. Safeway and especially Whole Foods Market are general...
Abstract 4368560: Interoceptive Sensibility is Associated to Self-Care in Cardiovascular Disease
Background: Self-care can improve several outcomes in patients with cardiovascular disease, but its practice may be hindered by some factors, including deficits in interoceptive ab...
Abstract 4365875: Bilateral Left Lateral Ridge Ablation In Patients With Paroxysmal Atrial Fibrillation (RIDGE-AF): Study Rationale and Preliminary Results
Introduction and Background: Left lateral atrial ridge (LLR) is sited between the orifices of the left pulmonary veins (PVs) and the left atrial appendage (LAA) ostium and is the c...
Abstract 4366848: Advance-HTN Trial Participant Characteristics Associated with a Failure to be Randomized
Background: Placebo or sham-controlled clinical trials of new hypertension therapies often use run-in periods to assess participant adherence to background antihypertensive (AHT) t...
Abstract 4370493: Hypercholesterolemia polygenic score modulates response to statin therapy
Background: Studies have shown that individuals with high CAD PGS have greater reduction in cardio outcomes from statin use than do those with low PGS. Here, we quantify the effect...
Abstract 4368951: Myocardial Features, Intracardiac Thrombosis and Coronary Artery Disease Assessment with Cardiac Computed Tomography in Cardiac Amyloidosis (MYOAMY CT)
Backround: Cardiac amyloidosis (CA) leads to restrictive cardiomyopathy, heart failure, and increased thromboembolic risk. This hypercoagulability condition is determined by the me...
Abstract 4368153: Protecting Minds Globally: Hypertension-Driven Cognitive Decline Causes 12.3 Million Years of Disability
Background: Hypertension is a key contributor to cognitive decline, significantly impacting global neurological health. Using Global Burden of Disease (GBD) 2019 data, we quantifie...
Abstract 4337342: Relationship Between Circulating Cardiac Troponin I Levels and Coronary Flow Reserve in a Porcine Model of Chronic Coronary Artery Disease
Introduction: Recent clinical data have revealed a role for circulating cardiac troponin I (cTnI) concentrations as a prognostic tool in patients with stable coronary artery diseas...
Abstract 4369336: Effects of Finerenone on Heart Failure Outcomes According to Baseline Heart Failure Risk: Insights from the FIDELITY Program
Introduction: The non-steroidal mineralocorticoid receptor antagonist finerenone reduces the risk of heart failure (HF) hospitalization in people with type 2 diabetes and chronic k...
Abstract 4363742: Food Insecurity Drives Obesity: Highlighting the Hunger–Obesity Paradox Across the United States
Background: Obesity-related cardiovascular death rates in the U.S. have nearly tripled over the past two decades, rising from 2.2 to 6.6 deaths per 100,000 people, highlighting a g...
Abstract 4360699: Hemodynamic Regulation of FOXO1 Integrates Endothelial Inflammation and Metabolism in Atherosclerosis
Background: Atherosclerosis occurs preferentially in regions of disturbed or low fluid shear stress (FSS), whereas physiological laminar FSS protects against disease by suppressing...