Abstract Sun205: Study on the Role of CTRP7 in Aggravating Brain Injury after Cardiopulmonary Resuscitation

Abstract

Background: C1q/TNF-related protein 7 (CTRP7), a significant adipokine primarily secreted by adipocytes, serves as a key effector molecule in vascular remodeling signaling pathways and inflammatory responses. This study aimed to investigate the association between serum CTRP7 levels and short-term outcomes following return of spontaneous circulation (ROSC). Methods: A retrospective cross-sectional study was conducted using clinical data from in-hospital cardiac arrest (IHCA) patients treated at West China hospital between 00:00 on January 31, 2021, and 23:59 on January 31, 2022, in combination with an established biobank. Serum CTRP7 concentrations were compared between neurological outcome groups 28 days post-ROSC to evaluate their correlation with short-term neurological prognosis. Results: A total of 129 IHCA patients were included. Serum CTRP7 concentrations were significantly higher in the 28-day mortality group (P<0.05) and in patients with poor 28-day neurological outcomes (P<0.05). Among survivors at 28 days, CTRP7 levels were positively correlated with Cerebral Performance Category (CPC) scores (r=0.415, P<0.001). The area under the ROC curve (AUC) for CTRP7 in predicting 28-day mortality was 0.713 (95% CI: 0.625-0.791), with 58.49% sensitivity and 83.10% specificity. The AUC for predicting poor 28-day neurological outcomes was 0.682 (95% CI: 0.561-0.787), with 66.67% sensitivity and 72.00% specificity, indicating that serum CTRP7 has moderate predictive value for short-term neurological prognosis after CPR. Conclusions: In IHCA patients, elevated serum CTRP7 levels after CPR are associated with increased mortality and worse neurological outcomes, suggesting its potential as a prognostic biomarker.