Circulation
Articles in this Issue
Abstract 4368121: Association Between Myocardial Lipomatous Metaplasia And Sudden Cardiac Death In Patients With Prior Myocardial Infarction
Objective: Infarcted myocardium can be infiltrated by adipose cells, known as lipomatous metaplasia (LM). It has been suggested that LM may provide a substrate for post-infarct ven...
Abstract 4359691: Factor XI Inhibition with AB023 Prevents Mechanical Valve Thrombosis in a Porcine Pulmonary Model Without Bleeding Events
Background: Mechanical heart valves offer lifelong durability but require continuous anticoagulation to prevent thrombosis. Vitamin K antagonists (VKAs) remain the standard of care...
Abstract 4362881: Left Bundle Branch Area Pacing Versus Non-Conduction System Pacing After Atrioventricular Node Ablation in Atrial Fibrillation: Impact on Atrial and Ventricular Function
Background: Atrioventricular node (AVN) ablation combined with pacing is a well-established therapy for refractory atrial fibrillation. Traditional right ventricular pacing has bee...
Abstract 4370772: Chronic Migraine Alters Heart-Brain Connectivity: Insights from Fragmentation Analysis of Heart Rate Variability
Introduction: Heart rate fragmentation (HRF) is an inter-beat interval dynamics approach that enhances the analysis of short-term heart rate variability. HRF has been shown to refl...
Abstract 4372145: Meta-Analysis on Acute Pericarditis Treatment: Colchicine Alone vs. Colchicine + NSAIDs (Aspirin or Ibuprofen)
Acute pericarditis is an inflammatory condition of the pericardium, often presenting with chest pain, pericardial friction rub, and characteristic ECG changes. The management of acute pericarditis typ...
Abstract 4366312: Mobilization in Patients with Cardiogenic Shock Requiring Temporary Mechanical Circulatory Support: Safety and Association with Functional Outcomes
Background: Early mobilization is recommended by guidelines for all patients with critical illness, yet its safety and efficacy in patients with cardiogenic shock (CS) requiring te...
Abstract 4357141: Polygenic score analyses in a large multinational HCM clinical cohort identifies effects on disease penetrance and severity
Background: Disease expressivity in hypertrophic cardiomyopathy (HCM) varies widely, ranging from unaffected genetically predisposed individuals to life-threatening complications....
Abstract 4370426: Multi-Modality Imaging in Giant Cell Myocarditis
Background: Giant cell myocarditis (GCM) is a rare autoimmune cardiomyopathy that leads to fulminant heart failure. Diagnosis remains challenging, with many patients presenting lat...
Abstract 4369073: Perioperative Serum Creatinine Trajectories and 1-Year Survival After Coronary Artery Bypass Grafting
Background: Acute kidney injury (AKI) is a common complication following coronary artery bypass grafting (CABG). The Kidney Disease: Improving Global Outcomes (KDIGO) criteria effe...
Abstract 4341365: Prediction of Aspiration Pneumonia After Cardiac Surgery Using Preoperative Oral Frailty: A Logistic Model
Background: Aspiration pneumonia is a serious complication after cardiac surgery, particularly among older patients. Preoperative oral frailty—decline in oral function including po...
Abstract 4358699: Ethnic Disparities in Post-Stroke Antihypertensive Therapy Intensification: Insights from the National Inpatient Sample (2018–2023)
Background: Hypertension management is critical to preventing recurrent stroke, yet racial and ethnic disparities in post-stroke antihypertensive therapy intensification remain und...
Abstract 4360304: Leveraging the Role of Home Health Aides to Care for Adults with Heart Failure: Findings from a Pilot Randomized Controlled Trial
Background: Home health aides (HHAs) frequently care for heart failure (HF) patients, but many lack training, confidence, and cannot reach their nurse supervisors when they need he...
Abstract 4365719: Personal Care Product Usage Patterns And Hypertension In U.S. Women From The Sister Study
Introduction: Personal care products (PCPs) are complex chemical mixtures, which include endocrine disrupting chemicals linked to elevated risk of hormonally-responsive chronic dis...
Abstract 4370347: Comparative Performance Of Al-driven CCTA Models For Pre-TAVR CAD Detection: A Systematic Review
Introduction: Accurate assessment of coronary artery disease (CAD) before Transcatheter Aortic Valve Replacement (TAVR) is crucial for optimal outcomes. Al-...
Abstract 4359102: Trends in Incidence of Atrial Fibrillation in the Midwest USA from 2013 to 2023
Background: Atrial fibrillation (AF) is the most common sustained arrhythmia with prevalence increasing over the last decade. However, data on recent temporal trends in incidence o...
Abstract 4365531: Acoramidis Effect on All-Cause Mortality in Patients with p.V142I (V122I) Variant ATTR-CM: Findings From the ATTRibute-CM Study
Introduction: Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) arises from amyloidogenic aggregates of destabilized TTR protein in variant (ATTRv-CM) or acquired wild-type TTR...
Abstract 4371772: Outcomes of Oral Anticoagulant Discontinuation After Atrial Fibrillation Ablation: A Systematic Review and Meta-Analysis
Introduction: While current guidelines recommend Oral anti-coagulant (OAC) use for ≥2 months post-atrial fibrillation (AF) ablation, with long-term therapy based on stroke risk rat...
Abstract 4369080: Catheter ablation of epicardial premature ventricular complexes in patients with and without cardiac scar
Background: The left ventricular epicardium is a common site of origin (SOO) among patients with idiopathic premature ventricular complexes (PVCs) undergoing catheter ablation proc...
Abstract 4365058: Artificial Intelligence enabled Electrocardiograms (AI-ECG) and Pregnancy Related Cardiomyopathy: a Systematic Review and Diagnostic Meta-Analysis
Background: Cardiomyopathy occurring during pregnancy or in the postpartum period is a leading case of maternal death in the US. The most commonly described form of pregnancy relat...
Abstract 4368979: Inhibition of Cardiac GLUT1 Suppresses KLF5 Activation and Ameliorates Diabetic Cardiomyopathy
Introduction: Cardiomyocytes (CM) primarily rely on fatty acid oxidation (FA) for ATP production. Paradoxically, despite increased FA utilization in diabetes, humans and mice devel...
Abstract 4365858: Genetic Evaluation of Familial Hypercholesterolemia in a Pediatric Cardiology Clinic
Background: Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by elevated low density lipoprotein cholesterol (LDL-C) and increased lifetime risk o...
Abstract 4362834: A Remote Patient Care Heart Failure Program Drives Improved Clinical Outcomes and Reduced Healthcare Cost and Utilization
Introduction: Despite significant support of the clinical benefits of GDMT, heart failure (HF) patients have poor clinical outcomes and as a result high healthcare costs and utiliz...
Abstract 4366003: Anti-inflammatory effects of colchicine after myocardial infarction
Background: The molecular mechanisms underlying colchicine’s benefits after myocardial infarction (MI) remain unclear. This study aimed to investigate the impact of colchicine on t...
Abstract 4345451: Electrocardiographic Right Ventricular Hypertrophy Enhances Contemporary Risk Stratification in Predicting All-Cause Mortality in Mitral Transcatheter Edge-to-Edge Repair
Introduction: Right ventricular (RV) dysfunction is associated with poor outcomes following mitral transcatheter edge-to-edge repair (M-TEER) in patients with severe mitral regurgi...
Abstract 4371388: Comparison of In-Hospital Outcomes Between Type 1 and Type 2 Myocardial Infarction in Patients Admitted with Acute Decompensated Heart Failure: A Nationwide Analysis
Background: Patients with Type 2 myocardial infarction (MI) often exhibit unique characteristics and outcomes compared to those with Type 1 MI. Additionally, individuals with Type...