Circulation
Articles in this Issue
Abstract 4367452: Integrated Multi-omics Analysis of Skeletal Muscle in Response to a Bout of Resistance or Endurance Exercise
Introduction: The Molecular Transducers of Physical Exercise Consortium (MoTrPAC) was established to characterize the molecular basis of the health benefits of exercise. Here, we p...
Abstract 4358653: Effects of Bempedoic Acid on Venous Thromboembolism: a Post-Hoc Analysis of The CLEAR Outcomes Trial
Background: Venous thromboembolism (VTE), which encompasses deep vein thrombosis (DVT) and pulmonary embolism (PE), is a frequent condition that can lead to significant morbidity a...
Abstract 4361640: Finerenone Attenuates Cardiac Hypertrophy in a Mouse Model of HFpEF by Modulating Glucocorticoid and Mineralocorticoid Receptor Signaling
Background: The FINEARTS-HF trial demonstrated that finerenone significantly reduced cardiovascular death and total heart failure events in patients with mildly reduced or preserve...
Abstract 4370886: Trends and Disparities in Ischemic Heart Disease and Sleep Apnea–Related Mortality in the United States (1999–2020): A CDC WONDER Study.
Background: Sleep apnea is a major risk factor for ischemic heart disease (IHD), and the two conditions are closely related. Our study aims to examine mortality trends related to I...
Abstract 4344059: Local Application of Vancomycin Powder Reduces Postoperative Complications Following Median Sternotomy in Cardiac Surgery: A Randomized Controlled Trial
Introduction: Sternal wound infections (SWIs) are serious complications following median sternotomy in cardiac surgeries such as coronary artery bypass grafting (CABG), valve repla...
Abstract 4368026: Comprehensive echocardiographic analysis of optimized rodent models of heart failure with preserved ejection fraction identifies superior LV filling pressure surrogates
Background: In drug development, rodent models that faithfully recapitulate human disease are critical for evaluating the therapeutic effects and confirming the mechanisms of actio...
Abstract 4368634: Hepatic CXCL1 Contributes to Cardiac Dysfunction after Heart Failure
Background: Interorgan communication is essential for coordinating organ functions, maintaining homeostasis, and adapting to disease. Although the liver and heart engage in multifa...
Abstract 4365973: Circulating Angiopoietin-Like Protein 3 in Response to Statin Therapy in Acute Coronary Syndrome and Stable Coronary Artery Disease
Background: Anti-atherosclerotic response to statin has been shown to differ in patients with ACS and stable CAD. Statin induced a greater reduction of subsequent cardiac events’ r...
Abstract Sat106: Trends in emergency medical technician placed supraglottic airways for out-of-hospital cardiac arrests
Introduction: Airway management is a crucial component of advanced life support for out-of-hospital cardiac arrest (OHCA). Supraglottic airways (SGA) are a more easily placed alter...
Abstract 4365988: AI-informed Coronary Artery Tortuosity Index (CArTI) from Cardiac CT Angiography Predicts 5-Year Cardiovascular Risk
Introduction: Current cardiovascular risk models rely on clinical variables and atherosclerotic burden, overlooking subtle structural variations in coronary anatomy. Coronary arter...
Abstract 4363687: Demographic Patterns and Temporal Trends in Arrhythmia-Related Mortality Among U.S. Young Adults: A 22-Year CDC WONDER Analysis
Background: Arrhythmias represent a broad spectrum of abnormal heart rhythms that can range from benign to life-threatening. While often associated with older populations, arrhythm...
Abstract 4360190: Now You See It, Now You Don't: The Vanishing Act of a Type III Endoleak
Introduction: Type III endoleaks are a significant complication following endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAAs). They are characterized by persi...
Abstract 4367224: Systematic Evaluation of Commercial and Open-source Large Language Models for Automated Adjudication of Clinical Indication from Cardiac Magnetic Resonance Imaging Reports
Background: Indications for cardiac magnetic resonance imaging (CMR) are often stored in heterogenous, unstructured reports. Manual adjudication of indications is time-consuming an...
Abstract 4369348: Fully Automated Detection of Structural Heart Disease from Apple Watch ECGs Using a Noise-Adapted AI Algorithm: The WATCH-SHD Study
Background: Wearable devices can capture 1-lead ECGs but are primarily used for detecting rhythm disorders. AI deployed on these ECGs could enable scalable detection of structural...
Abstract 4371740: Characterizing Shared Genetic Architectures in Brain and Cardiovascular Diseases via Clustering of Survival GWAS Summary Statistics
Background: Clustering neurological, psychiatric, and cardiovascular diseases based on GWAS summary statistics offers opportunities to uncover their shared genetic architecture acr...
Abstract 4370034: Hemodynamic progression and predictors of symptomatic valve dysfunction after TAVR: A single-center study
Background: Presumed valvular dysfunction following transcatheter aortic valve replacement (TAVR) is a recognized phenomenon that may lead to increased transvalvular gradients, and...
Abstract 4358526: Concurrent Monitoring of Pulmonary Artery Diastolic Pressure (PADP) and Fluid Volume for More Accurate and Timely Detection of Worsening Heart Failure (HF)
PADP monitoring is being increasingly utilized to guide remote HF management with PADP often used as a surrogate for volume status. Yet, in a prior HF study, it was observed that PADP was not correlat...
Abstract 4366236: Metabolite Risk Score Predicts Sudden Death in Patients with Cardiovascular Disease and Preserved Systolic Function
Introduction: Sudden cardiac death (SCD) accounts for 15–20% of all deaths, and novel risk stratification tools are urgently needed to prevent the 75% of SCDs that occur in individ...
Abstract 4368267: Differences in Inflammatory Cell Profiles Between Early- and Late-Onset Immunotherapy-Induced Myocarditis: A Nationwide Endomyocardial Biopsy Study of the Japanese Population
Background: Although immune checkpoint inhibitor (ICI) myocarditis typically occurs soon after initiating checkpoint therapy (<90 days), it can also arise as a delayed complicat...
Abstract 4369028: Left Bundle Branch Area Pacing Redefines Physiological Stimulation Standards in High-Risk Cardiac Populations
Background: Left bundle branch area pacing (LBBAP) has emerged as a physiological alternative to conventional right ventricular pacing, yet its efficacy across diverse cardiac path...
Abstract 4369056: Association Between Creatinine-to-Cystatin C Ratio, Subclinical Myocardial Injury, and Mortality: National Health and Nutrition Examination Survey
Background: The creatinine-to-cystatin C ratio (CCR) is an emerging biomarker of skeletal muscle health that predicts cardiovascular outcomes. Subclinical myocardial injury (SCMI)...
Abstract 4362723: Cardiovascular Outcomes in Patients with Obstructive Sleep Apnea: A 15-Year Nationwide Population-Based Study
Background: Obstructive sleep apnea (OSA) is increasingly recognized as a risk factor for cardiovascular diseases. However, long-term population-based data evaluating its associati...
Abstract 4365541: Dagliflozin Ameliorates Perirenal Adipose Tissue-Derived Leptin-Induced Renal Tubular Injury In Obese Hypertensive Mice
Background: Adipocytokines leptin from perirenal adipose tissue (PRAT) is implicated in the pathogenesis of obesity-associated hypertension. This study was to demonstrate whether d...
Abstract 4370459: Dynamic PET Imaging Quantifies Absolute Measures of Calf Muscle Perfusion in a Porcine Model of Peripheral Endovascular Arterial Occlusion and PAD Patients with Claudication
Introduction: Peripheral artery disease (PAD) is an atherosclerotic disorder of the lower extremities promoting muscle ischemia. Our lab previously validated the use of fluorine-18...
Abstract 4348252: GENDER DIFFERENCES IN THE IMPACT OF APPARENTLY RESISTANT HYPERTENSION ON TARGET ORGAN LESIONS AND PATIENT PROGNOSIS
Introduction: Complications of arterial hypertension(AH) are more frequent in patients with resistant AH(RH), defined as blood pressure(BP) ≥ 140x90 mmHg, despite ≥ 3 antihypertens...