Circulation
Articles in this Issue
Abstract 4363303: An Artificial Intelligence-Enhanced Echocardiographic Characterization of Cardiac Masses
Background: Cardiac masses are of challenging diagnostic characterization, with differentiation difficulties on echocardiographic images, particularly in differentiating tumors fro...
Abstract 4354815: Optimal hemodynamic status and prognostic predictors in patients with right ventricular dysfunction: the RIGHT study
Background: Optimal hemodynamics for right ventricular dysfunction (RVD) differs from those for left ventricular dysfunction. However, evidence regarding optimal hemodynamics and p...
Abstract Sat104: Airway Opening Index in Cardiopulmonary Resuscitation
Background: Airway opening index (AOI) characterizes EtCO 2 distortions from chest compressions. We sought to determine the associations bet...
Abstract 4355856: The Obesity Paradox Still Exists in Heart Failure: A Dose-Response Meta-Analysis of Body Mass Index and Mortality Across Diverse Subgroups
Background: Despite obesity being a major cardiovascular risk factor, studies in heart failure populations have reported an inverse association between body mass index and mortalit...
Abstract 4365332: Inhibition of PARP-1 selectively improves diastolic function in diabetic rat: potential role of glycocalyx protection.
Background: Diabetic heart failure is characterised by predominantly diastolic dysfunction and has been associated with impaired cardiac energetics and inflammation. We recently fo...
Abstract 4367813: Nonischemic Late Gadolinium Enhancement Associated with Adverse Remodeling is an Underrecognized Predictor of Heart Failure Outcomes Post-Myocardial Infarction
Background: Nonischemic late gadolinium enhancement (NI-LGE) may serve as a predictor of heart failure (HF) adverse outcomes in ischemic heart disease. This study aimed to investig...
Abstract 4362891: Switch, Stop, or Continue? Data-Driven Guidance for Oral Anticoagulation in Japanese Patients with Atrial Fibrillation Aged ≥ 75 Years: Insights from the ANAFIE Registry
Background: Clinical decisions on oral anticoagulation (OAC) in atrial fibrillation (AF) become increasingly complex with age because thromboembolic and hemorrhagic risks rise toge...
Abstract 4343089: Severe Hypoxic Respiratory Failure After Watchman Device Implantation in a Patient With Bioprosthetic Tricuspid Stenosis and Persistent iASD
Case Description: A 54-year-old male with ESRD on hemodialysis, tricuspid valve endocarditis status post bioprosthetic valve replacement, and atrial fibrillation status post cathet...
Abstract 4368581: Relationship Between Unilateral Antegrade Cerebral Perfusion, Peripheral Immune Hyper-Reactivity and Cognition in a Translational Model of Hypothermic Circulatory Arrest
Introduction: Hypothermic circulatory arrest (HCA) is associated with neurological damage. During HCA, antegrade cerebral perfusion (ACP) supports neuroprotection by perfusing the...
Abstract 4365441: The Prevalence of Clinical Atherosclerosis in Denmark
Background: Atherosclerotic cardiovascular disease is a leading cause of death globally, accounting for approximately a third of all deaths. Atherosclerosis is a systemic and progr...
Abstract 4342870: Hypertension-Associated Cancer Mortality: A 20-Year United States Comorbid Mortality Analysis From 1999 to 2020
Introduction: Hypertension is a common comorbidity in cancer patients and may worsen prognosis. Despite its relevance, long-term trends in hypertension-associated cancer mortality...
Abstract 4366441: The association between smoking and albuminuria in a population with a substantial burden of cardiovascular disease
Background: According to the global burden of cardiovascular diseases (CVD), Egypt experiences one of the highest CVD-related mortalities. Albuminuria is recognized as a risk marke...
Abstract 4364146: Racial Disparities in Transcatheter Aortic Valve Replacement Utilization and Outcomes in the United States: A National Analysis (2016–2021)
Background: Transcatheter aortic valve replacement (TAVR) is a groundbreaking therapy for the management of severe aortic stenosis. Racial disparities in cardiovascular care includ...
Abstract 4366385: Improving Hypertension Control Rates by Implementing a Self-Monitored Blood Pressure Program
Introduction: Hypertension (HTN) is a major contributor to both heart disease and stroke, with a prevalence of 48%. While Black patients have a higher prevalence of HTN than their...
Abstract 4342075: Comprehensive Proteomics Profiling Identifies a Small Set of Circulating Biomarkers to Predict New-Onset Atrial Fibrillation, Worsening Heart Failure, and Major Adverse Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy
Background: Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease and can lead to atrial fibrillation (AF), heart failure (HF), and major adverse cardiovascula...
Abstract 4339547: Nicotinamide Nucleoside Transhydrogenase (NNT) loss-of-function attenuates oxidative stress-associated myocardial fibrosis and diastolic dysfunction in cardiometabolic HFpEF
Background: The absence of effective, disease-modifying therapies continues to limit clinical management of cardiometabolic heart failure with preserved ejection fraction (cHFpEF)....
Abstract 4362835: Divergent Roles of PDK2 and PDK4 in Regulating Survival, Hypertrophy, and Metabolism Under Physiological and Pathological Cardiac Stress
Cardiac hypertrophy can be induced by both physiological (e.g., exercise) and pathological (e.g., pressure overload) stress. These adaptive responses are accompanied by distinct shifts in myocardial e...
Abstract 4363754: The Gut-Heart Axis: A Systematic Review of Gut Microbiota Dysbiosis and Atherosclerosis Pathogenesis
Introduction: Atherosclerosis, an immunoinflammatory disease of medium and large arteries, involves endothelial cells, leukocytes, and smooth muscle cells, causing plaque formation...
Abstract 4365072: Immune checkpoint inhibitor myocarditis presenting as acute coronary syndrome
Case: A 64-year-old male with stage IV squamous cell carcinoma on durvalumab (last dose 2 months prior) presented with acute dyspnea on exertion. Vitals were notable for heart rate...
Abstract 4363487: Immersive Healing: Approach to Easing Anxiety in Pediatric Cardiology Outpatient Procedures through Virtual Reality Distracting Techniques
Background: Virtual reality (VR) coping has recently flourished into a popular distractor in pediatric medical environments. This study aims to assess the effectiveness of VR versu...
Abstract 4364029: Biventricular Pressure-Volume Loop Assessment of Impella 5.5 in a Porcine Model of Myocardial Infarction
Introduction: Microaxial flow pumps reduce mortality in myocardial infarction (MI) related cardiogenic shock (CS). The Impella 5.5 generates increased flow to provide circulatory s...
Abstract 4358040: Sex-, Age-, and Chamber-Specific Atrial Remodeling Predicts Driver-Ablation Outcomes in Persistent Atrial Fibrillation
Background: In persistent atrial fibrillation (perAF), atrial remodeling driven by age, biological sex, and comorbidities can create arrhythmogenic substrates beyond the pulmonary...
Abstract 4372294: Effective Atomic Numbers and Electron Density of Focal Peri-Pulmonary Arterial Adipose Tissue on Spectral CT Can Predict Elevated Pulmonary Arterial Systolic Pressure in Patients without Coronary Arterial, Myocardial, and Valvular Diseases
Introduction: Inflammation in pericoronary adipose tissue may occur focally at adjacent plaque sites in the coronary arterial system. Similarly, inflammation in peri-pulmonary arte...
Abstract 4371720: Using Contemporary, Real World Pediatric Pulmonary Hypertension Data to Investigate the Current Treatment Strategies, Survival, and Hospitalization Rates
Background: Presently pediatric pulmonary hypertension (PH) lacks a widely accepted risk assessment algorithm and clear guidelines for treatment. Most targeted therapies are used o...
Abstract 4368586: Longitudinal protein associations with impaired fasting glucose (IFG) and diabetes in MESA
Intro: Circulating diabetes protein biomarkers have been studied in large human cohorts using measurements from a single timepoint. There are limited studies, however, on how prote...