Circulation
Articles in this Issue
Abstract 4371722: Cardiac Arrhythmia-Related Mortality in Adults with Aplastic Anemia in the United States: A 25-Year Nationwide Analysis (1999–2023)
Background: Aplastic anemia (AA), a rare hematologic disorder characterized by bone marrow failure, predisposes patients to multisystem complications. Cardiac arrhythmias, potentia...
Abstract 4372989: Single-Nucleus RNA Sequencing Reveals Cell-Type–Specific Transcriptional Dysregulation in Pediatric Congenital Heart Disease: A Systematic Review and Meta-Analysis
Background: Pediatric congenital heart disease (CHD) is associated with disrupted cellular development and long-term cardiovascular risk. Single-nucleus RNA sequencing (snRNA-seq)...
Abstract 4368413: Selective Sedation: Patient Characteristics Associated with Sedative Choice in Cardiogenic Shock
Introduction: Propofol has demonstrated favorable outcomes in mechanically ventilated ICU patients, including shorter ventilation times and ICU stays. However, its use in cardiogen...
Abstract 4368296: Epigenetic Age Acceleration Mediates the Link Between Dietary Inflammatory Index, Oxidative Balance Score, and Mortality in U.S. Adults with Cardiovascular-Kidney-Metabolic Syndrome
Background: The interplay between dietary patterns, epigenetic aging, and cardiovascular-kidney-metabolic (CKM) syndrome remains poorly understood. This study investigated the asso...
Abstract 4364648: Mortality Risk Among Patients with Cardiogenic Shock due to Light-Chain Amyloidosis
Background: Light-chain (AL) amyloidosis is a multisystem disorder characterized by the deposition of misfolded monoclonal immunoglobulin light chains in various organs including t...
Abstract 4344139: Global, Regional, and National Burden of Early-onset Atrial Fibrillation/Atrial Flutter: an Analysis of the Global Burden of Disease Study 2021
Background: While atrial fibrillation/flutter is widely recognized as a growing public health concern, the specific burden of early-onset cases remains unclear....
Abstract 4359641: Use Of Argatroban Plus Antiplatelet Therapy In Patients With Non-Cardioembolic Stroke: A Systematic Review And Meta-Analysis.
The evidence of argatroban and antiplatelet therapy in patients with acute non-cardioembolic stroke ineligible for intravenous thrombolysis or thrombectomy is relatively limited. This meta analysis ai...
Abstract 4363229: Prognostic Impact of Baseline Frailty, Malnutrition, or Both on Mortality for Patients Admitted with Acute Decompensated Heart Failure
Introduction: Malnutrition and frailty are highly prevalent among heart failure (HF) patients and have been shown to independently affect outcomes. However, these diagnoses are oft...
Abstract 4356626: The Obesity Paradox in Heart Failure: Exploring the Impact of BMI on 30-Day Readmission Rates in a Community Safety-Net Hospital
Background: Obesity is a well-established risk factor for the development of congestive heart failure (CHF), yet its impact on hospital readmission rates remains unclear. Some stud...
Abstract 4373512: Age and Gender Disparities in Burden of Hypertensive Heart Disease Attributable to Lead Exposure from 1990 to 2021: A Global Benchmarking Analysis
Age and Gender Disparities in Burden of Hypertensive Heart Disease Attributable to Lead Exposure from 1990 to 2021: A Global Benchmarking Analysis Background:...
Abstract 4373117: Quantum Computing based Echocardiographic Diagnosis and Analysis in Congenital Heart Disease: Feasibility and Superiority to conventional Deep Learning Approaches
Background: Quantum computing (QC) has emerged as an innovative technology to enhance machine learning through quantum mechanical properties such as superposition, entanglement, an...
Abstract 4365928: RT-A1: A Novel Dual GC-A and GC-B Peptide Activator that Attenuates Adverse Myocardial Remodeling in Pre-Clinical Heart Failure with Preserved Systolic Function
Background: Heart failure (HF) is a complex syndrome marked by adverse cardiac remodeling and natriuretic peptide (NP) deficiency, which drives disease progression despite current...
Abstract 4370432: Cardiovascular Event Rates by Baseline Risk and Age in a Primary Prevention Cohort from the All of Us Research Program
Introduction: Among adults without established atherosclerotic cardiovascular disease (ASCVD), risk exists along a continuum, and real-world data characterizing this spectrum, part...
Abstract 4368073: Heart Failure Symptom Cluster Phenotypes and Their Influencing Factors Vary Across Population Groups: A Secondary Data Analysis from the <i>All of Us</i> Research Program
Introduction: Limited knowledge exists on physiological, psychological, and situational influencing factors of heart failure (HF) symptom clusters across different population group...
Abstract 4365086: The Amyloid Paradox: Breakthrough Therapies Drive Diagnostic Recognition, Not Disease Burden
Introduction: Cardiac amyloidosis has undergone revolutionary changes since 2018, with breakthrough therapies demonstrating 30-36% mortality reductions and noninvasive diagnostic a...
Abstract 4370981: Second-Harmonic Generation and Atomic Force Microscopy Correlative Map of the Cardiovascular Tissue Stress-Strain Response
Introduction: Microscale mechanical dysfunctions of the heart underlie hypertrophic cardiomyopathies, yet modeling local tissue mechanics remains prohibitively challenging without...
Abstract 4365029: Temporal Association and Prognosis of Atrial Fibrillation/Flutter with Heart Failure and its Subtypes in Post-menopausal Women: A Women’s Health Initiative Study
Introduction: Heart failure (HF) and atrial fibrillation/flutter (AF) often co-occur in older adults. Understanding the temporal relationship of HF and its subtypes (HFpEF and HFrE...
Abstract 4369372: Trends and Disparities in Mortality from Thyrotoxicosis and Heart Failure in the United States from 1999 to 2023.
Abstract: Background: Thyrotoxicosis, a reversible endocrine disorder, significantly affects cardiovascular outcomes, particularly by worsening heart failure (HF). Cardiac problems...
Abstract 4366646: Inpatient Outcomes of Left Atrial Appendage Occlusion in Patients with Advanced Chronic Kidney Disease Compared to End-Stage Renal Disease: A Nationwide Analysis
Background: Left atrial appendage occlusion (LAAO) is an alternative to anticoagulation for stroke prevention in atrial fibrillation (AF), particularly for high bleeding risk patie...
Abstract 4363122: Temporal Trends in Major Adverse Cardiovascular Events Following Hospitalization for Myocardial Infarction Between 2008-2022: Insights from the Veterans Affairs Healthcare System
Background: Over 800,000 individuals are hospitalized for a myocardial infarction (MI) annually in the United States. Temporal trends in post-discharge outcomes are uncertain....
Abstract 4337014: Association of Clonal Hematopoiesis with Incident Heart Failure in 360,000 Individuals
Background: Clonal hematopoiesis of indeterminate potential (CHIP) is the aging-related clonal expansion of hematopoietic cells with preleukemic mutations. CHIP is an independent p...
Abstract 4357291: Telecommunicator Cardiopulmonary Resuscitation Performance Metrics and Barriers to Implementation in Birmingham, Alabama
Background: Bystander CPR (B-CPR) rates in Birmingham, Alabama are significantly below the national average, contributing to one of the lowest out-of-hospital cardiac arrest (OHCA)...
Abstract 4366812: Combined Efficacy, Safety, and Test Dose Tolerability of Etripamil for Acute Paroxysmal Supraventricular Tachycardia (PSVT) Across Multiple Clinical Trials
Background: Etripamil nasal spray is a fast-acting, calcium channel blocker in development for the conversion of paroxysmal supraventricular tachycardia (PSVT) outside of a health-...
Abstract 4364521: The Predictive Capabilities of Exhaled Volatile Organic Compounds on Heart Failure Status: A Pilot Study
Background: Exhaled volatile organic compounds (VOCs) can provide insight into various physiological and metabolic processes....
Abstract 4364240: Congestion Limits Reduction in Left Ventricular Pressure-Volume Area Due to Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) in Acute Myocardial Infarction
Background: Use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasing in acute myocardial infarction (AMI) and heart failure associated cardiogenic shock. We...