Circulation
Articles in this Issue
Abstract Sun802: Intravenous versus Intraosseous Vasopressor Administration During Cardiopulmonary Resuscitation of Asphyxiated Neonatal Piglets
Background: Current neonatal resuscitation guidelines recommend epinephrine preferably be given via intravenous (IV) or intraosseous (IO) routes during cardiac arrest. Vasopressin...
Abstract 4367430: Prevalence of Dysglycemia-Based Chronic Disease in Iranian Adults
Background: The Dysglycemia-Based Chronic Disease (DBCD) multi-morbidity care model was developed by American Association of Clinical Endocrinology to address the requirement for p...
Abstract 4368363: TRIM35 Exacerbates Myocardial Delayed Reperfusion Injury by Ubiquitin-Mediated Degradation of EN1 and Disruption of Mitochondrial Respiratory Complex
Background: Delayed reperfusion (DR) in myocardial ischemia causes long-term cardiac dysfunction, partially due to impaired mitochondrial quality control. TRIM35 is an E3 ubiquitin...
Abstract 4345868: Machine learning prediction of myocardial ischemia using quantitative assessment of coronary calcifications in non-contrast CT calcium scoring scans
Introduction: Non-contrast computed tomography calcium scoring (CTCS) provides a direct, noninvasive measure of atherosclerotic plaque burden by detecting calcified lesions in the...
Abstract 4361892: CKD and CKM Syndrome: Accelerated Progression to Arrhythmias in a National Cohort
Introduction: Chronic kidney disease (CKD), a key element of the AHA Cardiovascular-Kidney-Metabolic (CKM) framework, is increasingly recognized as an independent risk factor for a...
Abstract 4366301: Effects on major adverse cardiovascular events in persons treated with sotagliflozin: Prespecified pooled analyses of the Phase 3 type 2 diabetes program
Background: In the SCORED trial that included 10,584 participants with type 2 diabetes (T2D) and chronic kidney disease (CKD), sotagliflozin significantly reduced the incidence of...
Abstract 4369980: Impact of Socioeconomic Food Insecurity on Stroke Outcomes: A County-Level Geospatial Analysis Using CDC WONDER and USDA Data
Background: Food insecurity, defined as having limited or unpredictable access to enough food, is a severe public health issue that disproportionately affects socioeconomically dis...
Abstract 4357820: Proteomic and Phosphoproteomic Profiling of Cardiac Left Ventricular Tissue from an Animal Model of Early Stage Heart Failure with Preserved Ejection Fraction after Soluble Guanylate Cyclase Stimulation
Introduction/Background: Stimulation of soluble guanylate cyclase (sGC) represents a promising pharmacological strategy in the treatment of heart failure with reduced ejection frac...
Abstract 4369143: Outcomes After Heart Transplantation in Adults with Congenital Heart Disease – A Single Center Experience
Background: The purpose of this study was to describe outcomes after heart transplantation in adults with congenital heart disease (CHD) based on the experience from a high volume...
Abstract 4362257: Medicare Advantage Chronic Condition Special Needs Plans (C-SNPs) for People with HF: Better Care or Just Marketing?
Background: Medicare patients with cardiovascular disease (CVD) are increasingly enrolling in Medicare Advantage (MA), the private alternative to traditional Medicare. One emerging...
Abstract 4370936: Cardiogenic Shock due to Flecainide Toxicity: No substitute for time.
Flecainide has a narrow therapeutic index, and at toxic levels can induce a dangerous wide complex rhythm. Here we describe a refractory case of cardiogenic shock due to flecainide toxicity and how th...
Abstract 4361034: Spread of heated tobacco products and hospitalizations of acute coronary syndrome
Background: Heated tobacco products (HTPs) have gained traction as alternatives to conventional cigarettes. Its use is rapidly gaining popularity among young adults since 2017, esp...
Abstract 4369899: Artificial Intelligence for Diagnosing Low-Gradient Aortic Stenosis Using Echocardiographic Imaging.
Backround: Artificial intelligence (AI) may assist in diagnosing the most challenging subtype of aortic stenosis (AS) — low-gradient (LG) AS, characterized by a discordance between...
Abstract 4368448: Real World utilization of Influenza vaccination as a secondary prevention strategy for Major cardiovascular event in Acute Coronary Syndrome
Background: Influenza infection is a significant contributor to morbidity and mortality among patients with acute coronary syndrome (ACS). Despite strong guideline recommendations...
Abstract 4365666: Accelerated Biological Aging, Early-Life Exposure to Tobacco, and Incident Aortic Aneurysm: A Large-Scale Prospective Cohort Study in UK Biobank
Background: Aortic aneurysm (AA) is a fatal vascular disease that affects life expectancy. Theory predicts that biological processes of aging may better capture vascular aging than...
Abstract 4371100: Intergenerational and Individual Cardiometabolic Risk Among Black Adults in the All of US Research Program: The Role of Nativity Status
Family history of cardiovascular disease is a known risk factor for cardiometabolic conditions, yet few studies have examined how nativity shapes intergenerational cardiometabolic risk patterns among...
Abstract 4355469: AI-driven Aortic Valve Calcification Measurement in Coronary Artery Calcium Scan Detects Aortic Stenosis Comparably to Human Experts: An AI-CVD Study within the Framingham Heart Study
Background: Aortic valve calcification (AVC) is an early marker of aortic stenosis but is not routinely scored and reported in coronary artery calium (CAC) scans. Traditional manua...
Abstract 4364400: DENND3-p.R534S Induces Electrophysiological Instability by Intracellular Calcium Mishandling in Cardiomyocytes
Background: Previously, we discovered that DENND3, a guanine nucleotide exchange factor regulating Rab GTPases, influences cardiac ion channel trafficking. Both electrophysiologica...
Abstract 4357907: Not What It Seems: A Case of Dynamic LVOT Obstruction Masquerading as Prosthetic Aortic Valve Stenosis
Description of Case: A 63-year-old woman with nonischemic cardiomyopathy (CM) with recovered ejection fraction (EF), severe bicuspid aortic valve (AV) stenosis post-transcatheter a...
Abstract 4368550: Screening for Chagas Cardiomyopathy in a Community in Northern Argentina
Introduction: Chagas disease is a vector-borne parasitic infection endemic to Latin America. After acute infection resolves, approximately 30% of patients may progress to the chron...
Abstract 4370510: <i>Modeling ER Stress-Driven Vascular Remodeling Using a Novel 3D-Bioprinted Human Pulmonary Artery Model</i>
Background: Pulmonary arterial hypertension (PAH) is a progressive vasculopathy driven by endothelial cell (EC) dysfunction, smooth muscle cell (SMC) proliferation, and medial thic...
Abstract 4371061: Trends and Disparities in Heart Failure Mortality Among US Adult Females with Breast Cancer from 1999 to 2020: A 22-Year Retrospective Study
Background: Heart failure (HF) significantly impacts mortality among breast cancer patients. Studies indicate that breast cancer patients aged 65+ with HF have reduced long-term su...
Abstract 4358111: Variability of Outpatient Cardiology Clinician Performance Metric Achievement in the Veteran Affairs Health System
Introduction: Quality improvement interventions may seek to identify positive and negative outlier clinicians to promote practice change. We sought to assess variability in perform...
Abstract 4364732: MiR-331-3p promotes vascular remodeling in atherosclerosis by modulating smooth muscle cell behavior
Atherosclerosis is a primary contributor to cardiovascular mortality. The pathological proliferation, migration to the intima, and phenotypic switching of Smooth Muscle Cells (SMCs) leads to vascular...
Abstract 4358485: Impact of Mavacamten on Left and Right Ventricular Function and Hemodynamics in Obstructive Hypertrophic Cardiomyopathy
Background: Obstructive hypertrophic cardiomyopathy (oHCM) features left ventricular hypertrophy, dynamic LV outflow tract (LVOT) obstruction, and diastolic dysfunction, often caus...