Circulation
Articles in this Issue
Abstract 4371104: Trends and Disparities in Malnutrition and Heart Failure-Related Deaths Among United States Adults: A CDC WONDER Analysis (1999-2020)
Background: Heart failure (HF), affecting approximately 6.2 million adults in the U.S., correlates strongly with malnutrition. The relationship between HF and malnutrition is well-...
Abstract 4365563: Treg-derived Sparc confers cardioprotection against acute myocardial infarction in mice via promoting collagen synthesis and deposition
Introduction: We previously reported that cardiac Tregs exhibited a unique phenotype after acute myocardial infarction (AMI) and promoted tissue repair through the secretion of sec...
Abstract 4357821: Sirt5 maintains mitochondrial homeostasis by inhibiting ANT2 lysine lactation modification to improve cardiac function in ischemia-reperfusion injury
Introduction: Myocardial ischemia-reperfusion (IR) injury is the most common type of heart disease. IR-disrupted mitochondrial homeostasis affects heart energy metabolism and funct...
Abstract 4359642: Efficacy And Safety Of Intravenous Thrombolytics For Acute Ischemic Stroke Beyond 4.5 Hours: A Systematic Review And Meta-Analysis.
The thrombolytic agents are effective and generally used within 4.5 hours after the acute ischemic stroke (AIS). However, the evidence regarding the efficacy and safety of thrombolytics beyond 4.5 hou...
Abstract 4370764: Single Chamber (Right Atrial) Leadless Pacemaker to Prevent Ventricular Tachycardia
Introduction: Sudden changes in ventricular cycle lengths (or short-long-short [S-L-S] sequences) can initiate polymorphic ventricular tachycardia (VT). This pattern involves a pre...
Abstract 4364312: Laroprovstat (AZD0780) an oral, small molecule PCSK9 inhibitor demonstrates improvements in the lipid profile in participants with hypercholesterolemia: Results from a Phase 1 study
Introduction: Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) is an effective adjunct therapy for reducing low-density lipoprotein cholesterol (LDL-C) in patien...
Abstract 4367962: Developing a Standardized Index to Assess National Capacity for Cardiothoracic Surgical Care
Introduction: Cardiothoracic diseases remain a leading cause of mortality globally, with a significant proportion amenable to surgical intervention....
Abstract 4367459: Complementary Health Approach Engagement of People with Heart Disease in a Nationally Representative Sample
Background: Heart disease (HD) remains the leading cause of death in the U.S. and globally, with growing prevalence and cost. Complementary health approaches (CHAs) have risen in u...
Abstract 4370304: Phenotyping Lipid-Lowering Therapies for Patients with ASCVD
Background: Statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are used to lower low-density lipoprotein (LDL) to below 70 mg/dL ("at-goal")...
Abstract 4373565: Long-team outcome of common carotid artery occlusion: endovascular treatment VS open surgical treatment
Objective: The objective of this study was to introduce our institutional experience of treatment strategies (endovascular treatment and open surgical treatment) for the common car...
Abstract 4362430: Maternal Socioeconomic Status Impacts Diagnosis and Surveillance of Anti-Ro/SSA Positive Pregnancies Complicated by Fetal Cardiac Neonatal Lupus: A Fetal Heart Society (FHS) Research Collaborative Study
Introduction: Knowing maternal anti-Ro antibody status prior to pregnancy is important since surveillance can detect early and treatable manifestations of fetal cardiac neonatal lu...
Abstract 4358538: Targeting Liver Epsins Ameliorates Dyslipidemia in Atherosclerosis through Inhibition of Proprotein Convertase Subtilisin/Kexin Type 9-Mediated Low-density Lipoprotein Receptor Degradation
Background: The low-density lipoprotein receptor (LDLR) in the liver plays a crucial role in clearing low-density lipoprotein cholesterol (LDL-C) from the bloodstream. Under athero...
Abstract 4366536: Patient-Level Factors Associated with Frequent, Intense, and Nocturnal Lower Extremity Pain Experience Prior Revascularization in Patients with Chronic Limb-Threatening Ischemia
Background: Pain is a primary symptom of chronic limb-threatening ischemia (CLTI), yet its association with patient-level factors is unclear. Identifying the key characteristics of...
Abstract 4367039: Last-Resort Rotational Atherectomy for Balloon-Uncrossable Calcified SVG to OM Graft: A Case Report
Heavily calcified SVG lesions are rare and challenging, with limited evidence supporting atherectomy during PCI. Case: A 75-year-old female w...
Abstract 4367828: Pacemaker Magnetic Resonance Imaging: Building Equity for Patients with Cardiovascular Implantable Electronic Devices
Background: More than 2 million people in the United States have cardiovascular implantable electronic devices (CIEDs), such as pacemakers or implantable cardioverter defibrillator...
Abstract 4371465: Rural-Urban Disparities in Catheter Ablation for Atrial Fibrillation and Heart Failure
Introduction: Current US guidelines and recent trial data recommend patients with comorbid heart failure (HF) and atrial fibrillation (AF) should be considered for catheter ablatio...
Abstract 4358186: Aortic Dissection-Related Mortality in Hypertensive U.S. Adults: A 25-Year Portrait of Trends and Disparities From 1999 to 2023
Background: Aortic dissection is a life-threatening cardiovascular emergency with hypertension recognized as its most significant modifiable risk factor. Despite advances in diagno...
Abstract 4357058: Heart Failure Exacerbates Renal Medullary Hypoxia and Increases Acute Kidney Injury Risk After Cardiopulmonary Bypass in Sheep.
Background: Acute kidney injury (AKI) is a major unresolved complication of cardiac surgery, particularly in patients with pre-existing heart failure (HF). Mechanistic insight has...
Abstract 4368984: Telehealth Use Prior to Diagnosis Associated with Earlier Transthyretin Cardiac Amyloidosis (ATTR-CM) Disease Stage
Introduction: Early diagnosis of transthyretin cardiac amyloidosis (ATTR-CM) is integral to the success of effective treatment. While prior studies have explored sociodemographic d...
Abstract 4370840: Heparin-Resistant Massive Pulmonary Embolism in a Young Female: A Multi-Hit Thrombotic Storm
Case Description: An 18-year-old female presented to the emergency department with acute-onset dyspnea, chest pain, nausea, vomiting, and syncope after four months of oral contrace...
Abstract 4367731: Early DOAC (≤ 6 Days) After AF-Stroke Lowers Recurrent Ischemia Without Raising Symptomatic ICH: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Introduction: Early direct-oral-anticoagulant (DOAC) therapy after atrial-fibrillation–related ischemic stroke is disputed; guideline of delaying up to two weeks from vitamin-K-ant...
Abstract 4357342: Cerebellar and Cerebral Frontal Lobe Alterations in Pulmonary Hypertension: Evidence of an Inflammatory Lung Vascular-Brain Axis
Background: Connections between vascular and neurocognitive diseases are emerging but remain poorly defined. Cognitive impairments have been reported in pulmonary hypertension (PH)...
Abstract 4365081: Association of County-Level School Expenditure per Student During Childhood with Cardiovascular Health in Young Adulthood
Background: There is a well-established link between educational attainment and health outcomes. Area-level investment in education is an upstream contributor to individual-level e...
Abstract 4367374: Paradoxical Embolism from a Port-a-Catheter-Associated Thrombus Striking a Patent Foramen Ovale: A Rare Cause of TIA
Background: Paradoxical embolism through a patent foramen ovale (PFO) is a recognized cause of cryptogenic stroke and transient ischemic attacks (TIAs), especially in patients with...
Abstract 4359960: A Rare Case of Mycotic Pseudoaneurysm in a Pediatric Patient with a History of Disseminated MRSA
Mycotic pseudoaneurysms can be fatal due to spontaneous rupture and therefore early diagnosis may prevent such outcome. However, this proves to be a challenge due to non-specific symptoms such as back...