Circulation
Articles in this Issue
Abstract 4370319: Early Safety Signals and Common Pitfalls of the TriClip™ System for Transcatheter Tricuspid Valve Repair: Analysis of FDA's MAUDE Database
Background: Tricuspid regurgitation (TR) can lead to right ventricular failure (RVF) and poor clinical outcomes. The TriClip™ G4 transcatheter edge-to-edge repair (TEER) system has...
Abstract 4368935: Neutrophil Extracellular Trap Formation (NETosis) in Atherosclerosis and Acute Coronary Syndromes (ACS): A Systematic Review and Meta-Analysis
Background: Neutrophil extracellular traps (NETs), formed via NETosis, have emerged as key mediators linking inflammation and thrombosis in cardiovascular disease. While mechanisti...
Abstract 4373262: Impact of β-Blocker Nebivolol versus Bisoprolol Prescription at Discharge on Long-term Clinical Outcomes in ST elevation Myocardial Infarction Patients with Reduced Left Ventricular Ejection Fraction (<40%) treated with Drug-eluting Stents
Background: The comparative long-term outcomes of Nebivolol and Bisoprolol in ST-segment elevation myocardial infarction (STEMI) patients with reduced left ventricular ejection fra...
Abstract 4369718: Right atrial contraction function measured by echocardiography predicting atrioventricular synchrony for Micra-AV leadless pacemaker
Background: Micra-AV leadless pacemaker could achieve atrioventricular synchrony (AVS) by sensing atrial mechanics. However, Micra-AV showed low atrial tracking capability and AVS...
Abstract 4371733: Exercise versus Regadenoson for Myocardial Perfusion Assessment in Hypertrophic Cardiomyopathy
Background: Despite limited supporting evidence, adenosine-based vasodilators have become the default stress test agents in hypertrophic cardiomyopathy (HCM), where perfusion defec...
Abstract 4365934: Investigating causal links and molecular pathways that govern organ dysfunction in cardiovascular and chronic kidney disease
Cardiac and renal dysfunction are tightly linked, with each accelerating the other and undermining cardiovascular–kidney–metabolic health. Renal impairment is now recognized as a pivotal intermediary...
Abstract 4336054: Extracorporeal membrane oxygenation and the Gender Divide: A Systematic Review and Meta-Analysis of Sex-Based Differences in Outcomes
Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an increasingly utilized method for circulatory support. However, despite continued research, survival ra...
Abstract 4367253: Comparing visual attention and CPR quality among physicians with variable experience levels in simulated pediatric CPR
Introduction: Pediatric cardiac arrest (PCA) is a low-frequency, high acuity event, and mortality is twice as high for arrests that occur in a rural hospital compared to a children...
Abstract 4371139: Dual Antiplatelet Therapy post Intravenous Thrombolysis in patients with Minor Ischemic Stroke: A Systematic Review and Meta-analysis
Introduction: Minor ischemic stroke, though often less disabling, carries a substantial risk of early recurrence. Intravenous thrombolysis remains the standard for acute management...
Abstract 4373517: Coupling of Brain Oxygenated Blood Flow and Cerebrospinal Fluid Inflow in Hypertensive Patients: a Dynamic Glymphatic Marker
Introduction: The glymphatic system ensures the clearance of toxic byproducts of cerebral metabolism and relies on the movement of cerebrospinal fluid (CSF) through the perivascula...
Abstract 4368571: Left Atrial Appendage Occlusion Is Safe and Effective in Cardiac Amyloidosis: Real-World Single-Center Experience
Background: Cardiac amyloidosis (CA) is associated with increased thromboembolic risk, particularly in patients with atrial fibrillation (AF), who often also have high bleeding ris...
Abstract 4366079: Intronic Alu editing regulates Cathepsin K expression in atherosclerotic cardiovascular disease
Introduction: Despite therapeutic advances, atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death in industrialized nations, highlighting the need for p...
Abstract 4363927: An Unlikely Host: A Rare Case of Streptococcus Pneumoniae Purulent Pericarditis in an Immunocompetent Patient
Introduction: Purulent pericarditis is a rare, potentially fatal infection characterized by pus in the pericardial space. The most common culprit is streptococcus pneumoniae, and i...
Abstract 4366146: Adenine accumulation in Endothelial Cells Induces Cardiotoxicity in Type 2 Diabetes
People living with T2DM are twice as likely to develop and die from cardiovascular disease, such as heart attacks, and heart failure (HF). HF is a clinical syndrome characterized by a constellation of...
Abstract 4363991: The role of fibroblast activation protein on left ventricular growth and matrix signaling as a function of age
Background: Fibroblast activation protein (FAP) is abundantly expressed in cancer associated fibroblasts and contributes to extracellular matrix (ECM) remodeling. More recently, us...
Abstract 4360257: Superior Vena Cava Isolation Combined with Pulmonary Vein Isolation versus Pulmonary Vein Isolation Alone in Atrial Fibrillation Ablation: A Meta-Analysis of Randomized Controlled Studies with Trial Sequential Analysis
Background: Pulmonary vein isolation (PVI) is standard in atrial fibrillation (AF) ablation, but recurrence remains common. Non-pulmonary triggers, especially from the superior ven...
Abstract 4370663: The Curious Case of the Reverse Positive Bubble Study: A Mimicker of Persistent Left Superior Vena Cava
Persistent left superior vena cava (PLSVC) is a rare congenital anomaly, present in <1% of the population, typically draining into the coronary sinus and right atrium. When an anomalous drainage oc...
Abstract 4361008: Longitudinal Echocardiographic Assessment of Subacute Cardiotoxicity in a Prospective Cohort of Adolescents and Young Adults with Sarcoma Treated with High-Dose Doxorubicin
Introduction: Anthracycline-induced cardiomyopathy is a significant cause of morbidity and mortality among adolescents and young adults (AYAs) with sarcoma. Latency between myocard...
Abstract 4360612: Electrocardiogram-based Deep Learning to Predict Elevated Natriuretic Peptides at Guideline Thresholds for Heart Failure
Background: The prevalence of heart failure (HF) is rising, highlighting the need for early detection and intervention. Current Japanese HF guidelines define a B-type natriuretic p...
Abstract 4361255: Sex-related differences in clinical outcomes among heart failure patients with cardiac amyloidosis on SGLT2i therapy
Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have shown morbidity and mortality benefits in patients with heart failure (HF) and cardiac amyloidosis (CA). CA acco...
Abstract 4370717: Maternal GLP-1 Receptor Agonist Exposure and the Risk of Congenital Cardiovascular Defects: A Global Pharmacovigilance Study
Background: GLP-1 receptor agonists (GLP-1 RAs) are increasingly being recommended to women of reproductive age for the treatment of obesity and type II diabetes. However, their sa...
Abstract 4360223: Social Determinants of Health among Veterans with Peripheral Artery Disease
Background: Patients with peripheral artery disease (PAD) experience a high burden of limb-related hospitalizations and negative impacts on health-related quality of life. Although...
Abstract 4367726: Renal Tubular Knockout of Drd4 Leads to Salt-Sensitive Hypertension Associated with Increased Sodium Cotransporters in Mice
Global deficiency of the dopamine D4 receptor (D4R) has been associated with kidney-related hypertension and salt sensitivity. To specifically investigate the role of D4R in renal tubules, we generate...
Abstract 4367826: Outcomes Following Septal Myectomy in Young Patients with Obstructive Hypertrophic Cardiomyopathy
Background: Younger patients with obstructive hypertrophic cardiomyopathy (oHCM) who undergo septal myectomy (SM) tend to be a selected group, without many comorbidities like in ol...
Abstract Sat801: Discrepancies in Bystander CPR Documentation: Comparing the Birmingham CARES Data with 9-1-1 Audio Review
Background: Previous reports from the Cardiac Arrest Registry to Enhance Survival (CARES) have indicated a bystander cardiopulmonary resuscitation (B-CPR) rate of only 15.5% in Bir...