Circulation
Articles in this Issue
Abstract 4366354: Unmasking Risk: Clinical Outcomes of Moderate Aortic Stenosis with Concomitant Mitral Regurgitation—A Cardiac MRI-Based Evaluation
Objective: The clinical trajectory of patients with moderate aortic stenosis (AS) complicated by concomitant mitral regurgitation (MR) remains poorly defined. While management stra...
Abstract 4364542: Aspirin Use for Primary Prevention of Cardiovascular Events in High Risk Patients with Diabetes: A Propensity Matched Analysis
Background: Aspirin (ASA) use for primary prevention of ASCVD events is no longer regularly recommended. However, little is known about how ASA adherence influences cardiovascular...
Abstract 4360716: An Artificial Intelligence Model for Clinical Event Adjudication in Cardiovascular Clinical Trial
Adjudication of clinical events by a central event committee (CEC) is the gold standard to assess outcomes in randomized cardiovascular outcome trials (CVOT). The standard adjudication process is very...
Abstract 4357233: Evaluation of a Family-Centered Decision Aid on Parental Well-being After a Life-Threatening Congenital Heart Defect Diagnosis
Introduction: A prenatal diagnosis of severe congenital heart disease (CHD) can significantly impact parental physical and mental health as they face complex decisions about life-s...
Abstract 4370221: Trends and Reversal in Ischemic Stroke Mortality Among U.S. Adults Aged ≥75 Years (1999–2024): A National Analysis
Introduction/Background: US stroke death rates have declined for decades, but recent national data suggest plateauing or increases in some groups. It is unclear whether this trend...
Abstract 4365709: Obstructive Sleep Apnea, Adverse Cardiac Remodeling, and Inflammation
Background: Obstructive sleep apnea (OSA) has been linked to increased cardiovascular risk, potentially contributing to adverse cardiac remodeling and arrhythmias through inflammat...
Abstract 4367729: Omega-3 Fatty Acid Supplementation in Patients with Prior Myocardial Infarction Receiving Statin Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Background: The role of omega-3 fatty acids (O3-FAs) in secondary prevention following myocardial infarction (MI) remains uncertain in the era of high-intensity statin therapy, as...
Abstract 4372668: Machine Learning-based Mortality Prediction for Pediatric Fulminant Myocarditis Using Cytokine Profiles
Background: Fulminant myocarditis (FM) is a rare but life-threatening pediatric condition that rapidly progresses to cardiogenic shock and fatal arrhythmias. Prognostic biomarkers...
Abstract 4359772: A First-in-Class EV-miRNA Diagnostic System for Early Identification of IVIG-Resistant Kawasaki Disease
Background: Kawasaki disease (KD) is the leading cause of acquired heart disease in children in developed countries. Although IVIG is the standard therapy, ~17% of patients in Japa...
Abstract 4361830: Onset of Arrhythmias in the CKM Continuum: Real-World Insights from a National Cohort
Introduction: The AHA Cardiovascular-Kidney-Metabolic (CKM) framework outlines a continuum of risk, starting with metabolic dysfunction and leading to major cardiovascular events....
Abstract Sat1103: Associated Factors and Cardiac Arrest Duration for Favorable Neurological Outcomes in Out-of-Hospital Cardiac Arrest Due to Anaphylaxis: A Nationwide Retrospective Study
Background: Anaphylaxis is a life-threatening condition that can lead to out-of-hospital cardiac arrest (OHCA). Understanding the factors associated with neurological outcomes in a...
Abstract 4359514: Inhaled Nitric Oxide Impairs Mitochondrial Complex I Respiration Capacity and Increases Microglial Inflammation in Subcortical White Matter Following Deep Hypothermic Circulatory Arrest in Neonatal Swine
Background: Nitric oxide signaling can mediate ischemia-reperfusion injury by altering vascular resistance and inflammatory responses, including the production and degradation of r...
Abstract 4344116: Metabolomic Signatures of EAT-Lancet Diet Modify Air Pollution's Association with Type 2 Diabetes: A Prospective Study
Background: Air pollution is a significant risk factor for type 2 diabetes (T2D). While dietary factors may help mitigate T2D risk, traditional dietary assessments may not accurate...
Abstract 4365938: A Finding of Unique Peak Exercise Level in Respiratory Exchange Ratio during Bicycle Ergometric Cardiopulmonary Exercise Testing in Healthy Subjects
Backgrounds: In cardiopulmonary exercise testing (CPET), a peak respiratory exchange ratio (pRER) is used as a marker of effort adequacy for determining peak VO...
Abstract 4367190: Ventricular Tachycardia Ablation in Patients with and Without Chronic Kidney Disease
Background: Chronic kidney disease (CKD) is a commonly coexisting condition in patients undergoing ventricular tachycardia (VT) ablation and may be associated with worse procedural...
Abstract 4361958: Does invasive hemodynamic monitoring reduce mortality? A Meta-Analysis of pulmonary artery catheterization in cardiogenic shock
Introduction: Cardiogenic shock is a life-threatening complication of decompensated heart failure, with elevated in-hospital mortality rates despite advances in treatment. Pulmonar...
Abstract 4364889: Semiquantitative urine dipstick protein assessments predict clinical outcomes in patients with heart failure and reduced ejection fraction: Insights from the GALACTIC-HF trial
Background: Although it is known that increased urinary protein excretion is predictive of both end-stage kidney disease and cardiovascular (CV) outcomes, laboratory quantification...
Abstract 4367632: Perioperative NT-proBNP Change Predicts Adverse Outcomes After Septal Myectomy: A Nonlinear U-Shaped Association in Obstructive Hypertrophic Cardiomyopathy
Background: Although there have been some studies on the preoperative N-terminal pro-B-type natriuretic peptide (NT-proBNP), the prognostic significance of peri...
Abstract 4368520: Socioeconomic Disparities in Acute Ischemic Stroke Care Among Atrial Fibrillation Patients
Background: Atrial fibrillation (AF) is a common comorbidity in the U.S. and significantly contributes to the incidence of acute ischemic strokes. This study examines the impact of...
Abstract 4345985: PFO-Closure Induced Myopericarditis
Case Description: A 43-year-old female with a history of cryptogenic stroke and a large aneurysmal patent foramen ovale (PFO) underwent successful intra-cardiac echocardiography (I...
Abstract 4371535: Successful Surgical Intervention in a Rare Embolic MI with Severe Bioprosthetic Aortic Valve Stenosis, A Case Report
Introduction: Bioprosthetic valves are widely used for aortic valve replacement (AVR) and confer an excellent hemodynamic profile and reduced risk of thrombosis, but valve degenera...
Abstract 4362658: "Risk Score Scale" For Cardiovascular Events Based On The Coronary Computed Tomography Angiography Characteristics In Patients With Acute Coronary Syndrome
Introduction: Improving the risk stratification of cardiovascular events based on the analysis of structural changes in the coronary arteries in patients (pts) with ACS is relevant...
Abstract 4367431: Impact of Genetic Polymorphism on Antihypertensive Drug Response: Comparing ACE Inhibitors and ARBs – A Systematic Review and Meta-Analysis
Background: Pharmacogenomics is increasingly recognized as a key factor in optimizing antihypertensive therapy. Genetic polymorphisms may influence individual responses to commonly...
Abstract 4360243: Effective Restoration of Myocardium and Scar Reduction Post Myocardial Infarction with Intracoronary Cardiosphere-Derived Cells Therapy
Background: Ischemic heart disease, particularly myocardial infarction (MI), remains a major global health burden with a mortality rate of 5-30%, frequently resulting in irreversib...
Abstract 4369666: Prediction of Cyanotic Congenital Heart Disease Risk Reveals Maternal Age and Ethnicity, but Not Education, as Significant Factors in U.S. Births from 2022–2023
Background: Cyanotic congenital heart disease (CCHD) accounts for nearly one-third of infant mortality from congenital anomalies, yet the role of social determinants in its develop...